Histamine and Serotonin Levels in Bone Marrow Stem Cells Niche as Potential Biomarkers of Systemic Mastocytosis and Myeloproliferative Disorders
Bone marrow studies currently provide a lot of valuable information in the diagnostics of hematological diseases including hematopoietic stem cells disorders. Our studies on low-molecular weight organic compounds in bone marrow stem cell niche in various pathogenic conditions, revealed relatively hi...
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| Veröffentlicht in: | Stem cell reviews and reports 2023-04, Vol.19 (3), p.807-816 |
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| creator | Janus, Tomasz Korbal, Urszula Żukowski, Maciej Lewosiuk, Agnieszka Koper, Katarzyna Żukowska, Agnieszka Brzeźniakiewicz-Janus, Katarzyna |
| description | Bone marrow studies currently provide a lot of valuable information in the diagnostics of hematological diseases including hematopoietic stem cells disorders. Our studies on low-molecular weight organic compounds in bone marrow stem cell niche in various pathogenic conditions, revealed relatively high variability of histamine levels in different groups of hematological diseases. It was also found that serotonin levels were significantly lower than those typically measured in peripheral blood as well as many have the influence on stem cells proliferative potential. This paper presents findings from quantitative and statistical analyses of histamine and serotonin levels. Bone marrow collected from patients undergoing routine diagnostic procedures for hematological diseases and receiving inpatient treatment were analyzed. Histamine and serotonin levels were measured using hydrophilic interaction liquid chromatography (HILIC) coupled with tandem mass spectrometry. Obtained data were analyzed statistically and correlated with the diagnosed groups of hematological diseases and the parameters of complete blood counts. Histamine was found in all tested samples, including those from patients without malignancy, and the reported levels were comparable to the reference values in blood. This observation allows us to assume that bone marrow cells can produce and accumulate histamine. Moreover, the statistical analysis revealed a significant relationship between histamine levels and diagnosed mastocytosis, and between histamine levels and myeloproliferative neoplasms. Different results were obtained for serotonin, and its concentrations in most cases were below the limit of quantification of the method used ( |
| doi_str_mv | 10.1007/s12015-022-10502-0 |
| format | Article |
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Our studies on low-molecular weight organic compounds in bone marrow stem cell niche in various pathogenic conditions, revealed relatively high variability of histamine levels in different groups of hematological diseases. It was also found that serotonin levels were significantly lower than those typically measured in peripheral blood as well as many have the influence on stem cells proliferative potential. This paper presents findings from quantitative and statistical analyses of histamine and serotonin levels. Bone marrow collected from patients undergoing routine diagnostic procedures for hematological diseases and receiving inpatient treatment were analyzed. Histamine and serotonin levels were measured using hydrophilic interaction liquid chromatography (HILIC) coupled with tandem mass spectrometry. Obtained data were analyzed statistically and correlated with the diagnosed groups of hematological diseases and the parameters of complete blood counts. Histamine was found in all tested samples, including those from patients without malignancy, and the reported levels were comparable to the reference values in blood. This observation allows us to assume that bone marrow cells can produce and accumulate histamine. Moreover, the statistical analysis revealed a significant relationship between histamine levels and diagnosed mastocytosis, and between histamine levels and myeloproliferative neoplasms. Different results were obtained for serotonin, and its concentrations in most cases were below the limit of quantification of the method used (< 0.2 ng/mL), which can only be compared to peripheral blood plasma. In a few cases, significantly higher serotonin levels were observed and it concerned diseases associated with an increased number of megakaryocytes in the bone marrow.</description><identifier>ISSN: 2629-3269</identifier><identifier>EISSN: 2629-3277</identifier><identifier>DOI: 10.1007/s12015-022-10502-0</identifier><identifier>PMID: 36577910</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Biomarkers ; Biomedical and Life Sciences ; Biomedical Engineering and Bioengineering ; Bone marrow ; Bone Marrow - pathology ; Bone Marrow Cells ; Cell Biology ; Hematologic Diseases - pathology ; Hematological diseases ; Hematology ; Hematopoietic stem cells ; Histamine ; Humans ; Life Sciences ; Liquid chromatography ; Malignancy ; Mass spectroscopy ; Mastocytosis ; Mastocytosis, Systemic - diagnosis ; Mastocytosis, Systemic - pathology ; Megakaryocytes ; Molecular weight ; Myeloproliferative diseases ; Myeloproliferative Disorders - diagnosis ; Myeloproliferative Disorders - pathology ; Peripheral blood ; Regenerative Medicine/Tissue Engineering ; Serotonin ; Statistical analysis ; Stem Cells</subject><ispartof>Stem cell reviews and reports, 2023-04, Vol.19 (3), p.807-816</ispartof><rights>The Author(s) 2022</rights><rights>2022. The Author(s).</rights><rights>The Author(s) 2022. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). 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Our studies on low-molecular weight organic compounds in bone marrow stem cell niche in various pathogenic conditions, revealed relatively high variability of histamine levels in different groups of hematological diseases. It was also found that serotonin levels were significantly lower than those typically measured in peripheral blood as well as many have the influence on stem cells proliferative potential. This paper presents findings from quantitative and statistical analyses of histamine and serotonin levels. Bone marrow collected from patients undergoing routine diagnostic procedures for hematological diseases and receiving inpatient treatment were analyzed. Histamine and serotonin levels were measured using hydrophilic interaction liquid chromatography (HILIC) coupled with tandem mass spectrometry. Obtained data were analyzed statistically and correlated with the diagnosed groups of hematological diseases and the parameters of complete blood counts. Histamine was found in all tested samples, including those from patients without malignancy, and the reported levels were comparable to the reference values in blood. This observation allows us to assume that bone marrow cells can produce and accumulate histamine. Moreover, the statistical analysis revealed a significant relationship between histamine levels and diagnosed mastocytosis, and between histamine levels and myeloproliferative neoplasms. Different results were obtained for serotonin, and its concentrations in most cases were below the limit of quantification of the method used (< 0.2 ng/mL), which can only be compared to peripheral blood plasma. 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pathology</topic><topic>Bone Marrow Cells</topic><topic>Cell Biology</topic><topic>Hematologic Diseases - pathology</topic><topic>Hematological diseases</topic><topic>Hematology</topic><topic>Hematopoietic stem cells</topic><topic>Histamine</topic><topic>Humans</topic><topic>Life Sciences</topic><topic>Liquid chromatography</topic><topic>Malignancy</topic><topic>Mass spectroscopy</topic><topic>Mastocytosis</topic><topic>Mastocytosis, Systemic - diagnosis</topic><topic>Mastocytosis, Systemic - pathology</topic><topic>Megakaryocytes</topic><topic>Molecular weight</topic><topic>Myeloproliferative diseases</topic><topic>Myeloproliferative Disorders - diagnosis</topic><topic>Myeloproliferative Disorders - pathology</topic><topic>Peripheral blood</topic><topic>Regenerative Medicine/Tissue Engineering</topic><topic>Serotonin</topic><topic>Statistical analysis</topic><topic>Stem Cells</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Janus, Tomasz</creatorcontrib><creatorcontrib>Korbal, Urszula</creatorcontrib><creatorcontrib>Żukowski, Maciej</creatorcontrib><creatorcontrib>Lewosiuk, Agnieszka</creatorcontrib><creatorcontrib>Koper, Katarzyna</creatorcontrib><creatorcontrib>Żukowska, Agnieszka</creatorcontrib><creatorcontrib>Brzeźniakiewicz-Janus, Katarzyna</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Genetics Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Stem cell reviews and reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Janus, Tomasz</au><au>Korbal, Urszula</au><au>Żukowski, Maciej</au><au>Lewosiuk, Agnieszka</au><au>Koper, Katarzyna</au><au>Żukowska, Agnieszka</au><au>Brzeźniakiewicz-Janus, Katarzyna</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Histamine and Serotonin Levels in Bone Marrow Stem Cells Niche as Potential Biomarkers of Systemic Mastocytosis and Myeloproliferative Disorders</atitle><jtitle>Stem cell reviews and reports</jtitle><stitle>Stem Cell Rev and Rep</stitle><addtitle>Stem Cell Rev Rep</addtitle><date>2023-04-01</date><risdate>2023</risdate><volume>19</volume><issue>3</issue><spage>807</spage><epage>816</epage><pages>807-816</pages><issn>2629-3269</issn><eissn>2629-3277</eissn><abstract>Bone marrow studies currently provide a lot of valuable information in the diagnostics of hematological diseases including hematopoietic stem cells disorders. Our studies on low-molecular weight organic compounds in bone marrow stem cell niche in various pathogenic conditions, revealed relatively high variability of histamine levels in different groups of hematological diseases. It was also found that serotonin levels were significantly lower than those typically measured in peripheral blood as well as many have the influence on stem cells proliferative potential. This paper presents findings from quantitative and statistical analyses of histamine and serotonin levels. Bone marrow collected from patients undergoing routine diagnostic procedures for hematological diseases and receiving inpatient treatment were analyzed. Histamine and serotonin levels were measured using hydrophilic interaction liquid chromatography (HILIC) coupled with tandem mass spectrometry. Obtained data were analyzed statistically and correlated with the diagnosed groups of hematological diseases and the parameters of complete blood counts. Histamine was found in all tested samples, including those from patients without malignancy, and the reported levels were comparable to the reference values in blood. This observation allows us to assume that bone marrow cells can produce and accumulate histamine. Moreover, the statistical analysis revealed a significant relationship between histamine levels and diagnosed mastocytosis, and between histamine levels and myeloproliferative neoplasms. Different results were obtained for serotonin, and its concentrations in most cases were below the limit of quantification of the method used (< 0.2 ng/mL), which can only be compared to peripheral blood plasma. In a few cases, significantly higher serotonin levels were observed and it concerned diseases associated with an increased number of megakaryocytes in the bone marrow.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>36577910</pmid><doi>10.1007/s12015-022-10502-0</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0003-0247-4202</orcidid><orcidid>https://orcid.org/0000-0001-8918-1247</orcidid><orcidid>https://orcid.org/0000-0001-5733-0818</orcidid><orcidid>https://orcid.org/0000-0002-2363-2196</orcidid><orcidid>https://orcid.org/0000-0002-2376-9280</orcidid><orcidid>https://orcid.org/0000-0001-7305-1843</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Stem cell reviews and reports, 2023-04, Vol.19 (3), p.807-816 |
| issn | 2629-3269 2629-3277 |
| language | eng |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Biomarkers Biomedical and Life Sciences Biomedical Engineering and Bioengineering Bone marrow Bone Marrow - pathology Bone Marrow Cells Cell Biology Hematologic Diseases - pathology Hematological diseases Hematology Hematopoietic stem cells Histamine Humans Life Sciences Liquid chromatography Malignancy Mass spectroscopy Mastocytosis Mastocytosis, Systemic - diagnosis Mastocytosis, Systemic - pathology Megakaryocytes Molecular weight Myeloproliferative diseases Myeloproliferative Disorders - diagnosis Myeloproliferative Disorders - pathology Peripheral blood Regenerative Medicine/Tissue Engineering Serotonin Statistical analysis Stem Cells |
| title | Histamine and Serotonin Levels in Bone Marrow Stem Cells Niche as Potential Biomarkers of Systemic Mastocytosis and Myeloproliferative Disorders |
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