The anti-cancer agent APR-246 can activate several programmed cell death processes to kill malignant cells

Mutant TP53 proteins are thought to drive the development and sustained expansion of cancers at least in part through the loss of the wild-type (wt) TP53 tumour suppressive functions. Therefore, compounds that can restore wt TP53 functions in mutant TP53 proteins are expected to inhibit the expansio...

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Veröffentlicht in:	Cell death and differentiation 2023-04, Vol.30 (4), p.1033-1046
Hauptverfasser:	Wang, Zilu, Hu, Huimin, Heitink, Luuk, Rogers, Kelly, You, Yue, Tan, Tao, Suen, Connie Li Wai, Garnham, Alex, Chen, Hao, Lieschke, Elizabeth, Diepstraten, Sarah T., Chang, Catherine, Chen, Tianwei, Moujalled, Diane, Sutherland, Kate, Lessene, Guillaume, Sieber, Oliver M., Visvader, Jane, Kelly, Gemma L., Strasser, Andreas
Format:	Artikel
Sprache:	eng
Schlagworte:	13/106 13/2 38/22 38/44 42/44 45/41 631/45 631/80 692/699/67 Animals Antitumor agents Apoptosis Biochemistry Biomedical and Life Sciences Cancer Cell Biology Cell Cycle Analysis Cell death Cell Line, Tumor Clinical trials Ferroptosis Genes, p53 Life Sciences Lymphoma Mice Mutants Mutation Myc protein Necroptosis p53 Protein Stem Cells Transformed cells Tumor cell lines Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism Tumors
Online-Zugang:	Volltext
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