Single-cell RNA sequencing reveals unique monocyte-derived interstitial macrophage subsets during lipopolysaccharide-induced acute lung inflammation

Interstitial macrophages (IMs) reside in the lung tissue surrounding key structures including airways, vessels, and alveoli. Recent work has described IM heterogeneity during homeostasis, however, there are limited data on IMs during inflammation. We sought to characterize IM origin, subsets, and tr...

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Veröffentlicht in:	American journal of physiology. Lung cellular and molecular physiology 2023-04, Vol.324 (4), p.L536-L549
Hauptverfasser:	Moore, Peter K, Anderson, Kelsey C, McManus, Shannon A, Tu, Ting-Hui, King, Emily M, Mould, Kara J, Redente, Elizabeth F, Henson, Peter M, Janssen, William J, McCubbrey, Alexandra L
Format:	Artikel
Sprache:	eng
Schlagworte:	Folate Receptor 2 - metabolism Humans Inflammation - genetics Inflammation - metabolism Lipopolysaccharides - metabolism Lipopolysaccharides - pharmacology Macrophages - metabolism Monocytes - metabolism Pneumonia - chemically induced Pneumonia - genetics Pneumonia - metabolism Sequence Analysis, RNA - methods
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