Combinatorial treatment rescues tumour-microenvironment-mediated attenuation of MALT1 inhibitors in B-cell lymphomas

Activated B-cell-like diffuse large B-cell lymphomas (ABC-DLBCLs) are characterized by constitutive activation of nuclear factor κB driven by the B-cell receptor (BCR) and Toll-like receptor (TLR) pathways. However, BCR-pathway-targeted therapies have limited impact on DLBCLs. Here we used >1,100...

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Veröffentlicht in:	Nature materials 2023-04, Vol.22 (4), p.511-523
Hauptverfasser:	Shah, Shivem B., Carlson, Christopher R., Lai, Kristine, Zhong, Zhe, Marsico, Grazia, Lee, Katherine M., Félix Vélez, Nicole E., Abeles, Elisabeth B., Allam, Mayar, Hu, Thomas, Walter, Lauren D., Martin, Karen E., Gandhi, Khanjan, Butler, Scott D., Puri, Rishi, McCleary-Wheeler, Angela L., Tam, Wayne, Elemento, Olivier, Takata, Katsuyoshi, Steidl, Christian, Scott, David W., Fontan, Lorena, Ueno, Hideki, Cosgrove, Benjamin D., Inghirami, Giorgio, García, Andrés J., Coskun, Ahmet F., Koff, Jean L., Melnick, Ari, Singh, Ankur
Format:	Artikel
Sprache:	eng
Schlagworte:	631/67/70 639/166/985 Anticancer properties Attenuation Biomaterials Cell Line, Tumor Chemistry and Materials Science Combinatorial analysis Condensed Matter Physics Effectiveness Humans Hydrogels In vivo methods and tests Inhibitors Kinases Lymphoma Lymphoma, Large B-Cell, Diffuse - drug therapy Lymphoma, Large B-Cell, Diffuse - metabolism Materials Science Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein - metabolism Nanotechnology NF-kappa B - metabolism Optical and Electronic Materials Signal Transduction Signaling Translocation Tumor Microenvironment Tyrosine
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