O -GlcNAcylation promotes tumor immune evasion by inhibiting PD-L1 lysosomal degradation

Programmed-death ligand 1 (PD-L1) and its receptor programmed cell death 1 (PD-1) mediate T cell-dependent immunity against tumors. The abundance of cell surface PD-L1 is a key determinant of the efficacy of immune checkpoint blockade therapy targeting PD-L1. However, the regulation of cell surface...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2023-03, Vol.120 (13), p.e2216796120-e2216796120
Hauptverfasser:	Zhu, Qiang, Wang, Hongxing, Chai, Siyuan, Xu, Liang, Lin, Bingyi, Yi, Wen, Wu, Liming
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies Antitumor activity Apoptosis B7-H1 Antigen - metabolism Biological Sciences Cell death Cell Line, Tumor Cell surface Degradation Glycosylation Growth factors Hepatocyte growth factor Immune checkpoint inhibitors Immune Checkpoint Inhibitors - metabolism Immune evasion Immune response Immune system Immunity Intracellular Kinases Lymphocytes Lymphocytes T Lysosomes Lysosomes - metabolism Mice N-Acetylglucosamine O-GlcNAcylation PD-1 protein PD-L1 protein Peptide inhibitors Protein-tyrosine kinase Substrates Tumor cells Tumor Escape Tumors Tyrosine
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