Limb expression 1‐like protein promotes epithelial–mesenchymal transition and epidermal growth factor receptor‐tyrosine kinase inhibitor resistance via nucleolin‐mediated ribosomal RNA synthesis in non‐small cell lung cancer

Limb expression 1‐like protein (LIX1L) might be an RNA‐binding protein involved in post‐transcriptional regulation. However, little is known regarding the biological function and mechanism of LIX1L in cancer cells. Here we demonstrate a clear correlation between LIX1L expression and epithelial–mesen...

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Veröffentlicht in:	Cancer science 2023-04, Vol.114 (4), p.1740-1756
Hauptverfasser:	Li, Minglei, Zhang, Jiaxi, Meng, Xue, Liu, Bei, Xie, Shelly M., Liu, Fang, Yao, Demin, Zhang, Jingguo, Shen, Haitao, Xing, Lingxiao
Format:	Artikel
Sprache:	eng
Schlagworte:	Anoikis Apoptosis Autophagy-Related Proteins - metabolism Biosynthesis Carcinoma, Non-Small-Cell Lung - drug therapy Carcinoma, Non-Small-Cell Lung - genetics Carcinoma, Non-Small-Cell Lung - metabolism Cell Line, Tumor Cell migration Cell proliferation Cells Drug Resistance, Neoplasm EMT Enzyme inhibitors Epidermal growth factor Epidermal growth factor receptors Epithelial-Mesenchymal Transition - genetics ErbB Receptors Gene regulation Genes Genomes Humans Kinases LIX1L Lung cancer Lung Neoplasms - drug therapy Lung Neoplasms - genetics Lung Neoplasms - metabolism Metastasis Non-small cell lung carcinoma NSCLC Nucleoli Nucleolin Original Post-transcription Protein Kinase Inhibitors - pharmacology Proteins Ribosomal DNA ribosomal RNA synthesis Ribosomes - metabolism RNA polymerase RNA, Ribosomal - genetics RNA-binding protein RNA-Binding Proteins - genetics RNA-Binding Proteins - metabolism rRNA Small cell lung carcinoma Transforming growth factor-b1 Tumors Tyrosine Kinase Inhibitors
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