Inhibition of dopamine receptor D1 signaling promotes human bile duct cancer progression via WNT signaling

Bile duct cancer (BDC) frequently invades the nerve fibers, making complete surgical resection difficult. A single tumor mass contains cells of variable malignancy and cell‐differentiation states, with cancer stem cells (CSCs) considered responsible for poor clinical outcomes. This study aimed to in...

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Veröffentlicht in:	Cancer science 2023-04, Vol.114 (4), p.1324-1336
Hauptverfasser:	Yogo, Akitada, Masui, Toshihiko, Takaishi, Shigeo, Masuo, Kenji, Chen, Ru, Kasai, Yosuke, Nagai, Kazuyuki, Anazawa, Takayuki, Watanabe, Sadanori, Sakamoto, Satoko, Watanabe, Akira, Inagaki, Ryosaku, Nakagawa, Masahiro M., Ogawa, Seishi, Seno, Hiroshi, Uemoto, Shinji, Hatano, Etsuro
Format:	Artikel
Sprache:	eng
Schlagworte:	bile duct cancer Bile Duct Neoplasms - pathology Bile ducts Cancer cancer stem cells Cell differentiation Cell proliferation Chemotherapy Cholangiocarcinoma Dopamine Dopamine D1 receptors Enzymes Epidermal growth factor Fibroblasts Humans Malignancy Medical prognosis Organoids Original Phenotype Phenotypes Receptor mechanisms Receptors, Dopamine - genetics single‐cell analysis Spheres Spleen Stem cells Wnt protein Wnt Signaling Pathway
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