Chemical composition and swelling of normal and osteoarthrotic femoral head cartilage. I. Chemical composition
Radiochemical and biochemical methods were used to characterize post-mortem and osteoarthrotic femoral head cartilage. Fixed charge density measurements were correlated with glycosaminoglycan content as estimated by uronic acid and hexosamine analyses. In post-mortem cartilage water content decrease...
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| Veröffentlicht in: | Annals of the rheumatic diseases 1977-04, Vol.36 (2), p.121-129 |
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| container_title | Annals of the rheumatic diseases |
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| creator | Venn, M Maroudas, A |
| description | Radiochemical and biochemical methods were used to characterize post-mortem and osteoarthrotic femoral head cartilage. Fixed charge density measurements were correlated with glycosaminoglycan content as estimated by uronic acid and hexosamine analyses. In post-mortem cartilage water content decreased from a maximum at the surface to a minimum in the deep zones. In the osteoarthrotic specimens water content was greatest in the middle zones. Glycosaminoglycan content increased with depth and in the osteoarthrotic specimens was reduced throughout the depth of the cartilage. With increasing degeneration there was an increase in water content and decrease in glycosaminoglycan content. The difference in the water content profile in osteoarthrotic cartilage was explained in terms of damage to the collagen network. In osteoarthrosis the latter is no longer capable of restraining the swelling pressure produced by the glycosaminoglycans and swelling is greatest in the midzones, where glycosaminoglycan content is highest. |
| doi_str_mv | 10.1136/ard.36.2.121 |
| format | Article |
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I. Chemical composition</title><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><creator>Venn, M ; Maroudas, A</creator><creatorcontrib>Venn, M ; Maroudas, A</creatorcontrib><description>Radiochemical and biochemical methods were used to characterize post-mortem and osteoarthrotic femoral head cartilage. Fixed charge density measurements were correlated with glycosaminoglycan content as estimated by uronic acid and hexosamine analyses. In post-mortem cartilage water content decreased from a maximum at the surface to a minimum in the deep zones. In the osteoarthrotic specimens water content was greatest in the middle zones. Glycosaminoglycan content increased with depth and in the osteoarthrotic specimens was reduced throughout the depth of the cartilage. With increasing degeneration there was an increase in water content and decrease in glycosaminoglycan content. The difference in the water content profile in osteoarthrotic cartilage was explained in terms of damage to the collagen network. In osteoarthrosis the latter is no longer capable of restraining the swelling pressure produced by the glycosaminoglycans and swelling is greatest in the midzones, where glycosaminoglycan content is highest.</description><identifier>ISSN: 0003-4967</identifier><identifier>EISSN: 1468-2060</identifier><identifier>DOI: 10.1136/ard.36.2.121</identifier><identifier>PMID: 856064</identifier><identifier>CODEN: ARDIAO</identifier><language>eng</language><publisher>England: BMJ Publishing Group Ltd and European League Against Rheumatism</publisher><subject>Body Water - analysis ; Cartilage, Articular - analysis ; Chondroitin Sulfates - analysis ; Collagen - analysis ; Femur Head - analysis ; Glycosaminoglycans - analysis ; Humans ; Keratan Sulfate - analysis ; Middle Aged ; Osteoarthritis - metabolism</subject><ispartof>Annals of the rheumatic diseases, 1977-04, Vol.36 (2), p.121-129</ispartof><rights>Copyright BMJ Publishing Group LTD Apr 1977</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b4571-cfcc7727815df172cc183806fe58d2ea044dbff556541b443fa0293a89315be53</citedby><cites>FETCH-LOGICAL-b4571-cfcc7727815df172cc183806fe58d2ea044dbff556541b443fa0293a89315be53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1006646/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1006646/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/856064$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Venn, M</creatorcontrib><creatorcontrib>Maroudas, A</creatorcontrib><title>Chemical composition and swelling of normal and osteoarthrotic femoral head cartilage. I. Chemical composition</title><title>Annals of the rheumatic diseases</title><addtitle>Ann Rheum Dis</addtitle><description>Radiochemical and biochemical methods were used to characterize post-mortem and osteoarthrotic femoral head cartilage. Fixed charge density measurements were correlated with glycosaminoglycan content as estimated by uronic acid and hexosamine analyses. In post-mortem cartilage water content decreased from a maximum at the surface to a minimum in the deep zones. In the osteoarthrotic specimens water content was greatest in the middle zones. Glycosaminoglycan content increased with depth and in the osteoarthrotic specimens was reduced throughout the depth of the cartilage. With increasing degeneration there was an increase in water content and decrease in glycosaminoglycan content. The difference in the water content profile in osteoarthrotic cartilage was explained in terms of damage to the collagen network. In osteoarthrosis the latter is no longer capable of restraining the swelling pressure produced by the glycosaminoglycans and swelling is greatest in the midzones, where glycosaminoglycan content is highest.</description><subject>Body Water - analysis</subject><subject>Cartilage, Articular - analysis</subject><subject>Chondroitin Sulfates - analysis</subject><subject>Collagen - analysis</subject><subject>Femur Head - analysis</subject><subject>Glycosaminoglycans - analysis</subject><subject>Humans</subject><subject>Keratan Sulfate - analysis</subject><subject>Middle Aged</subject><subject>Osteoarthritis - metabolism</subject><issn>0003-4967</issn><issn>1468-2060</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1977</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kUuLFDEUhYP4alt3Ll0EBN1YZd5JbQRpHGdgUBCdhZuQSiXdaauSNqn28e_NUEOjIq4uuefj5N57AHiMUYsxFS9NHloqWtJigm-BFWZCNQQJdBusEEK0YZ2Q98GDUvb1iRRW98BdxQUSbAXiZuemYM0IbZoOqYQ5pAhNHGD57sYxxC1MHsaUp4pct1OZXTJ53uU0Bwu9m1Ku0s6ZAdraD6PZuhZetPBfzg_BHW_G4h7d1DX4dPbm4-a8uXz_9mLz-rLpGZe4sd5aKYlUmA8eS2ItVlQh4R1XA3EGMTb03nMuOMM9Y9QbRDpqVEcx7x2na_Bq8T0c-8kN1sW5TqkPOUwm_9TJBP2nEsNOb9M3jRESgolq8OzGIKevR1dmPYVi60VMdOlYtKIdk6yefw2e_gXu0zHHupzGUnSSKIxRpV4slM2plOz8aRSM9HWIuoaoayG6hljxJ7-Pf4KX1KrcLHKoYfw4qSZ_0UJSyfW7q42-OjtHHz6Taln55wvfT_v_f_wLhfu0zg</recordid><startdate>19770401</startdate><enddate>19770401</enddate><creator>Venn, M</creator><creator>Maroudas, A</creator><general>BMJ Publishing Group Ltd and European League Against Rheumatism</general><general>BMJ Publishing Group LTD</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>LK8</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19770401</creationdate><title>Chemical composition and swelling of normal and osteoarthrotic femoral head cartilage. I. Chemical composition</title><author>Venn, M ; Maroudas, A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b4571-cfcc7727815df172cc183806fe58d2ea044dbff556541b443fa0293a89315be53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1977</creationdate><topic>Body Water - analysis</topic><topic>Cartilage, Articular - analysis</topic><topic>Chondroitin Sulfates - analysis</topic><topic>Collagen - analysis</topic><topic>Femur Head - analysis</topic><topic>Glycosaminoglycans - analysis</topic><topic>Humans</topic><topic>Keratan Sulfate - analysis</topic><topic>Middle Aged</topic><topic>Osteoarthritis - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Venn, M</creatorcontrib><creatorcontrib>Maroudas, A</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Annals of the rheumatic diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Venn, M</au><au>Maroudas, A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chemical composition and swelling of normal and osteoarthrotic femoral head cartilage. I. Chemical composition</atitle><jtitle>Annals of the rheumatic diseases</jtitle><addtitle>Ann Rheum Dis</addtitle><date>1977-04-01</date><risdate>1977</risdate><volume>36</volume><issue>2</issue><spage>121</spage><epage>129</epage><pages>121-129</pages><issn>0003-4967</issn><eissn>1468-2060</eissn><coden>ARDIAO</coden><abstract>Radiochemical and biochemical methods were used to characterize post-mortem and osteoarthrotic femoral head cartilage. Fixed charge density measurements were correlated with glycosaminoglycan content as estimated by uronic acid and hexosamine analyses. In post-mortem cartilage water content decreased from a maximum at the surface to a minimum in the deep zones. In the osteoarthrotic specimens water content was greatest in the middle zones. Glycosaminoglycan content increased with depth and in the osteoarthrotic specimens was reduced throughout the depth of the cartilage. With increasing degeneration there was an increase in water content and decrease in glycosaminoglycan content. The difference in the water content profile in osteoarthrotic cartilage was explained in terms of damage to the collagen network. In osteoarthrosis the latter is no longer capable of restraining the swelling pressure produced by the glycosaminoglycans and swelling is greatest in the midzones, where glycosaminoglycan content is highest.</abstract><cop>England</cop><pub>BMJ Publishing Group Ltd and European League Against Rheumatism</pub><pmid>856064</pmid><doi>10.1136/ard.36.2.121</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Annals of the rheumatic diseases, 1977-04, Vol.36 (2), p.121-129 |
| issn | 0003-4967 1468-2060 |
| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Body Water - analysis Cartilage, Articular - analysis Chondroitin Sulfates - analysis Collagen - analysis Femur Head - analysis Glycosaminoglycans - analysis Humans Keratan Sulfate - analysis Middle Aged Osteoarthritis - metabolism |
| title | Chemical composition and swelling of normal and osteoarthrotic femoral head cartilage. I. Chemical composition |
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