Design, synthesis and biological evaluation of Nucleosidic CD99 inhibitors that selectively reduce Ewing sarcoma viability

Ewing Sarcoma (ES) is a cancer of bone and soft tissues affecting mostly children and young adults. Aggressive progression and poor prognosis of this malignancy call for novel and targeted treatments. CD99 is a transmembrane protein that is abundantly expressed on ES cells and is a diagnostic marker...

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Veröffentlicht in:	European journal of medicinal chemistry 2023-05, Vol.251, p.115244-115244, Article 115244
Hauptverfasser:	Balaraman, Kaluvu, Deniz, Emre, Nelson, Eryn, Pilicer, Samantha L., Atasoy, Sezen, Molotkova, Anna, Sevim, Handan, Tiwari, Purushottam B., Üren, Aykut, Wolf, Christian
Format:	Artikel
Sprache:	eng
Schlagworte:	12E7 Antigen CD99 inhibitors Cell Adhesion Molecules Child Cladribine Clofarabine Clofarabine - pharmacology DNA Ewing sarcoma Humans Nucleoside derivatization Sarcoma, Ewing - diagnosis Sarcoma, Ewing - drug therapy Sarcoma, Ewing - genetics Targeted therapy
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