Effect of iodine supplementation in pregnancy on neurocognitive development on offspring in iodine deficiency areas: a systematic review

To investigate the effect of iodine supplementation during gestation on the neurocognitive development of children in areas where iodine deficiency is common. Based on the PRISMA methodology, we conducted the search for articles in the PubMed, LILACS and Scopus databases, between March and April 202...

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Veröffentlicht in:Archives of Endocrinology and Metabolism 2021-06, Vol.65 (3), p.352-367
Hauptverfasser: Machamba, Almeida A L, Azevedo, Francilene M, Fracalossi, Karen O, do C C Franceschini, Sylvia
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container_title Archives of Endocrinology and Metabolism
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creator Machamba, Almeida A L
Azevedo, Francilene M
Fracalossi, Karen O
do C C Franceschini, Sylvia
description To investigate the effect of iodine supplementation during gestation on the neurocognitive development of children in areas where iodine deficiency is common. Based on the PRISMA methodology, we conducted the search for articles in the PubMed, LILACS and Scopus databases, between March and April 2020, without limitation of dates. We used descriptors in English, Portuguese, and Spanish, without filters. Four clinical trials and four cohort articles were included in the review. The maximum supplementation was 300 μg of potassium iodide per day. The Bayley scale and Children's Communication Checklist-Short were used to assess neurodevelopment in children. There was no significant improvement in the children's mental development index and behavioural development index in the supplemented group; however, the psychomotor development index (PDI) showed improvement in the poorer gross motor skills. We found differences in the response time to sound in the supplemented group living in mild deficiency areas. Daily supplementation with iodine can improve poor psychomotor development of children living in mild to moderate iodine deficiency areas. Thus, it is necessary to perform further studies to assess the effect of supplementation on neurodevelopment before, during and after gestation in mild to moderate iodine deficiency areas.
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subjects Child
cognition
Dietary Supplements
Female
Humans
Iodine
Potassium iodide
Pregnancy
Pregnancy Complications
pregnant woman
Review
title Effect of iodine supplementation in pregnancy on neurocognitive development on offspring in iodine deficiency areas: a systematic review
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