Biomarkers for predicting the prognosis of intrahepatic cholangiocarcinoma: A retrospective single-center study
The aim of this retrospective study was to investigate the association between preoperative serological and clinical indicators and postoperative recovery in patients who had undergone resection of intrahepatic cholangiocarcinoma (ICC). We collected data form the medical records of patients who unde...
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| Veröffentlicht in: | Medicine (Baltimore) 2023-03, Vol.102 (13), p.e33314-e33314 |
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| creator | Li, Xueliang Sun, Zhaowei Li, Xiaoxiao Wang, Qinlei Chen, Menshou Zhang, Bingyuan Feng, Yujie Han, Bing Hu, Xiao Guo, Jingyun Wang, Maobing Ma, Kai |
| description | The aim of this retrospective study was to investigate the association between preoperative serological and clinical indicators and postoperative recovery in patients who had undergone resection of intrahepatic cholangiocarcinoma (ICC). We collected data form the medical records of patients who underwent operations for the treatment of ICC at Qingdao University Affiliated Hospital from 2015 to 2021. We analyzed the data to explore the independent predictors of disease prognosis after surgery for ICC. By univariate analysis, we found that the following factors were significantly associated with overall survival and tumor-free survival in patients with ICCTNM stage; degree of vascular invasion; levels of hemoglobin, carcinoembryonic antigen, carbohydrate antigen 125, direct bilirubin, alkaline phosphatase, and albumin; prothrombin time; neutrophil to lymphocyte ratio; prothrombin time to albumin ratio; albumin to alkaline phosphatase ratio; albumin to gamma-glutamyl transferase ratio; prognostic nutrition Index, and incisional margin. However, only carbohydrate antigen 24-2 and glutamyl transpeptidase were correlated with overall survival in patients with ICC. However, only a positive history of biliary surgery was significantly associated with tumor-free survival in patients with ICC. Preoperative prothrombin time, vascular invasion, N-stage, incisal edge, and carcinoembryonic antigen levels may be simple predictors of disease progression in ICC after hepatectomy. |
| doi_str_mv | 10.1097/MD.0000000000033314 |
| format | Article |
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We collected data form the medical records of patients who underwent operations for the treatment of ICC at Qingdao University Affiliated Hospital from 2015 to 2021. We analyzed the data to explore the independent predictors of disease prognosis after surgery for ICC. By univariate analysis, we found that the following factors were significantly associated with overall survival and tumor-free survival in patients with ICCTNM stage; degree of vascular invasion; levels of hemoglobin, carcinoembryonic antigen, carbohydrate antigen 125, direct bilirubin, alkaline phosphatase, and albumin; prothrombin time; neutrophil to lymphocyte ratio; prothrombin time to albumin ratio; albumin to alkaline phosphatase ratio; albumin to gamma-glutamyl transferase ratio; prognostic nutrition Index, and incisional margin. However, only carbohydrate antigen 24-2 and glutamyl transpeptidase were correlated with overall survival in patients with ICC. However, only a positive history of biliary surgery was significantly associated with tumor-free survival in patients with ICC. Preoperative prothrombin time, vascular invasion, N-stage, incisal edge, and carcinoembryonic antigen levels may be simple predictors of disease progression in ICC after hepatectomy.</description><identifier>ISSN: 0025-7974</identifier><identifier>EISSN: 1536-5964</identifier><identifier>DOI: 10.1097/MD.0000000000033314</identifier><identifier>PMID: 37000091</identifier><language>eng</language><publisher>United States: Lippincott Williams & Wilkins</publisher><subject>Albumins ; Alkaline Phosphatase ; Bile Duct Neoplasms - pathology ; Bile Ducts, Intrahepatic - pathology ; Carbohydrates ; Carcinoembryonic Antigen ; Cholangiocarcinoma - pathology ; gamma-Glutamyltransferase ; Hepatectomy ; Humans ; Observational Study ; Prognosis ; Retrospective Studies</subject><ispartof>Medicine (Baltimore), 2023-03, Vol.102 (13), p.e33314-e33314</ispartof><rights>Lippincott Williams & Wilkins</rights><rights>Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc.</rights><rights>Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc. 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4515-9bdc1376a46c9b0fd5d8c23145b1d7ea8af6e7dfce6cc249c5aa635b0070b9dd3</citedby><cites>FETCH-LOGICAL-c4515-9bdc1376a46c9b0fd5d8c23145b1d7ea8af6e7dfce6cc249c5aa635b0070b9dd3</cites><orcidid>0000-0002-9546-550 ; 0000-0002-9546-550X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10063263/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10063263/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37000091$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Xueliang</creatorcontrib><creatorcontrib>Sun, Zhaowei</creatorcontrib><creatorcontrib>Li, Xiaoxiao</creatorcontrib><creatorcontrib>Wang, Qinlei</creatorcontrib><creatorcontrib>Chen, Menshou</creatorcontrib><creatorcontrib>Zhang, Bingyuan</creatorcontrib><creatorcontrib>Feng, Yujie</creatorcontrib><creatorcontrib>Han, Bing</creatorcontrib><creatorcontrib>Hu, Xiao</creatorcontrib><creatorcontrib>Guo, Jingyun</creatorcontrib><creatorcontrib>Wang, Maobing</creatorcontrib><creatorcontrib>Ma, Kai</creatorcontrib><title>Biomarkers for predicting the prognosis of intrahepatic cholangiocarcinoma: A retrospective single-center study</title><title>Medicine (Baltimore)</title><addtitle>Medicine (Baltimore)</addtitle><description>The aim of this retrospective study was to investigate the association between preoperative serological and clinical indicators and postoperative recovery in patients who had undergone resection of intrahepatic cholangiocarcinoma (ICC). We collected data form the medical records of patients who underwent operations for the treatment of ICC at Qingdao University Affiliated Hospital from 2015 to 2021. We analyzed the data to explore the independent predictors of disease prognosis after surgery for ICC. By univariate analysis, we found that the following factors were significantly associated with overall survival and tumor-free survival in patients with ICCTNM stage; degree of vascular invasion; levels of hemoglobin, carcinoembryonic antigen, carbohydrate antigen 125, direct bilirubin, alkaline phosphatase, and albumin; prothrombin time; neutrophil to lymphocyte ratio; prothrombin time to albumin ratio; albumin to alkaline phosphatase ratio; albumin to gamma-glutamyl transferase ratio; prognostic nutrition Index, and incisional margin. However, only carbohydrate antigen 24-2 and glutamyl transpeptidase were correlated with overall survival in patients with ICC. However, only a positive history of biliary surgery was significantly associated with tumor-free survival in patients with ICC. Preoperative prothrombin time, vascular invasion, N-stage, incisal edge, and carcinoembryonic antigen levels may be simple predictors of disease progression in ICC after hepatectomy.</description><subject>Albumins</subject><subject>Alkaline Phosphatase</subject><subject>Bile Duct Neoplasms - pathology</subject><subject>Bile Ducts, Intrahepatic - pathology</subject><subject>Carbohydrates</subject><subject>Carcinoembryonic Antigen</subject><subject>Cholangiocarcinoma - pathology</subject><subject>gamma-Glutamyltransferase</subject><subject>Hepatectomy</subject><subject>Humans</subject><subject>Observational Study</subject><subject>Prognosis</subject><subject>Retrospective Studies</subject><issn>0025-7974</issn><issn>1536-5964</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkUtv1DAUhS1ERYfCL0BCXrJJ8TMes0F98JJasYG15dg3E9NMHGynVf89nk4ptN5Yts_97jm-CL2h5JgSrd5fnh-Tf4tzTsUztKKSt43UrXiOVoQw2SitxCF6mfMvQihXTLxAh1ztSjRdoXga4tamK0gZ9zHhOYEProRpg8sA9Rg3U8wh49jjMJVkB5htCQ67IY522oTobHJhqpAP-AQnKCnmGSrhGnCumBEaB1OBhHNZ_O0rdNDbMcPr-_0I_fz86cfZ1-bi-5dvZycXjROSykZ33lWzrRWt0x3pvfRrx2pC2VGvwK5t34LyvYPWOSa0k9a2XHaEKNJp7_kR-rjnzku3Bb-zkOxo5hRq2lsTbTCPX6YwmE28NpSQlrOWV8K7e0KKvxfIxWxDdjDW1BCXbJjSXK8VkaxK-V7qavicoH_oQ4nZzcpcnpuns6pVb_-3-FDzdzhVIPaCmzjWD8xX43IDyQxgxzLc8aTSrGGE8YqkpKk3QvI_YWWi9A</recordid><startdate>20230331</startdate><enddate>20230331</enddate><creator>Li, Xueliang</creator><creator>Sun, Zhaowei</creator><creator>Li, Xiaoxiao</creator><creator>Wang, Qinlei</creator><creator>Chen, Menshou</creator><creator>Zhang, Bingyuan</creator><creator>Feng, Yujie</creator><creator>Han, Bing</creator><creator>Hu, Xiao</creator><creator>Guo, Jingyun</creator><creator>Wang, Maobing</creator><creator>Ma, Kai</creator><general>Lippincott Williams & Wilkins</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-9546-550</orcidid><orcidid>https://orcid.org/0000-0002-9546-550X</orcidid></search><sort><creationdate>20230331</creationdate><title>Biomarkers for predicting the prognosis of intrahepatic cholangiocarcinoma: A retrospective single-center study</title><author>Li, Xueliang ; Sun, Zhaowei ; Li, Xiaoxiao ; Wang, Qinlei ; Chen, Menshou ; Zhang, Bingyuan ; Feng, Yujie ; Han, Bing ; Hu, Xiao ; Guo, Jingyun ; Wang, Maobing ; Ma, Kai</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4515-9bdc1376a46c9b0fd5d8c23145b1d7ea8af6e7dfce6cc249c5aa635b0070b9dd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Albumins</topic><topic>Alkaline Phosphatase</topic><topic>Bile Duct Neoplasms - pathology</topic><topic>Bile Ducts, Intrahepatic - pathology</topic><topic>Carbohydrates</topic><topic>Carcinoembryonic Antigen</topic><topic>Cholangiocarcinoma - pathology</topic><topic>gamma-Glutamyltransferase</topic><topic>Hepatectomy</topic><topic>Humans</topic><topic>Observational Study</topic><topic>Prognosis</topic><topic>Retrospective Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Xueliang</creatorcontrib><creatorcontrib>Sun, Zhaowei</creatorcontrib><creatorcontrib>Li, Xiaoxiao</creatorcontrib><creatorcontrib>Wang, Qinlei</creatorcontrib><creatorcontrib>Chen, Menshou</creatorcontrib><creatorcontrib>Zhang, Bingyuan</creatorcontrib><creatorcontrib>Feng, Yujie</creatorcontrib><creatorcontrib>Han, Bing</creatorcontrib><creatorcontrib>Hu, Xiao</creatorcontrib><creatorcontrib>Guo, Jingyun</creatorcontrib><creatorcontrib>Wang, Maobing</creatorcontrib><creatorcontrib>Ma, Kai</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Medicine (Baltimore)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Xueliang</au><au>Sun, Zhaowei</au><au>Li, Xiaoxiao</au><au>Wang, Qinlei</au><au>Chen, Menshou</au><au>Zhang, Bingyuan</au><au>Feng, Yujie</au><au>Han, Bing</au><au>Hu, Xiao</au><au>Guo, Jingyun</au><au>Wang, Maobing</au><au>Ma, Kai</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Biomarkers for predicting the prognosis of intrahepatic cholangiocarcinoma: A retrospective single-center study</atitle><jtitle>Medicine (Baltimore)</jtitle><addtitle>Medicine (Baltimore)</addtitle><date>2023-03-31</date><risdate>2023</risdate><volume>102</volume><issue>13</issue><spage>e33314</spage><epage>e33314</epage><pages>e33314-e33314</pages><issn>0025-7974</issn><eissn>1536-5964</eissn><abstract>The aim of this retrospective study was to investigate the association between preoperative serological and clinical indicators and postoperative recovery in patients who had undergone resection of intrahepatic cholangiocarcinoma (ICC). We collected data form the medical records of patients who underwent operations for the treatment of ICC at Qingdao University Affiliated Hospital from 2015 to 2021. We analyzed the data to explore the independent predictors of disease prognosis after surgery for ICC. By univariate analysis, we found that the following factors were significantly associated with overall survival and tumor-free survival in patients with ICCTNM stage; degree of vascular invasion; levels of hemoglobin, carcinoembryonic antigen, carbohydrate antigen 125, direct bilirubin, alkaline phosphatase, and albumin; prothrombin time; neutrophil to lymphocyte ratio; prothrombin time to albumin ratio; albumin to alkaline phosphatase ratio; albumin to gamma-glutamyl transferase ratio; prognostic nutrition Index, and incisional margin. However, only carbohydrate antigen 24-2 and glutamyl transpeptidase were correlated with overall survival in patients with ICC. However, only a positive history of biliary surgery was significantly associated with tumor-free survival in patients with ICC. Preoperative prothrombin time, vascular invasion, N-stage, incisal edge, and carcinoembryonic antigen levels may be simple predictors of disease progression in ICC after hepatectomy.</abstract><cop>United States</cop><pub>Lippincott Williams & Wilkins</pub><pmid>37000091</pmid><doi>10.1097/MD.0000000000033314</doi><orcidid>https://orcid.org/0000-0002-9546-550</orcidid><orcidid>https://orcid.org/0000-0002-9546-550X</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Medicine (Baltimore), 2023-03, Vol.102 (13), p.e33314-e33314 |
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| language | eng |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Wolters Kluwer Open Health; IngentaConnect Free/Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Albumins Alkaline Phosphatase Bile Duct Neoplasms - pathology Bile Ducts, Intrahepatic - pathology Carbohydrates Carcinoembryonic Antigen Cholangiocarcinoma - pathology gamma-Glutamyltransferase Hepatectomy Humans Observational Study Prognosis Retrospective Studies |
| title | Biomarkers for predicting the prognosis of intrahepatic cholangiocarcinoma: A retrospective single-center study |
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