Linear Immunoglobulin A Dermatosis: A Rare Case Illustrating Successful Treatment With Dapsone
This is the case report of a previously healthy four-year-old girl with a history of upper airway infection that was treated with a β-lactam antibiotic. She was seen in the emergency department one month later with vesiculobullous lesions with clear content that were isolated or grouped in rosettes....
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| Veröffentlicht in: | Curēus (Palo Alto, CA) CA), 2023-02, Vol.15 (2), p.e35569 |
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| creator | Machado Morais, Joana Meneses, Mariana Freitas, Catarina Oliveira, Herberto Leite, Inês |
| description | This is the case report of a previously healthy four-year-old girl with a history of upper airway infection that was treated with a β-lactam antibiotic. She was seen in the emergency department one month later with vesiculobullous lesions with clear content that were isolated or grouped in rosettes. Direct immunofluorescence showed baseline linear positivity for immunoglobulin A (IgA) (+) and fibrinogen-positive bullous content with absent remaining immunosera expression. The observed results were compatible with linear IgA bullous dermatosis. After confirming the diagnosis and excluding glucose-6-phosphate dehydrogenase (G6PD) deficiency, dapsone was added to the initial treatment with systemic and topical corticosteroids. This case report is a reminder of the importance of a high index of clinical suspicion for this condition to reach a timely diagnosis. |
| doi_str_mv | 10.7759/cureus.35569 |
| format | Article |
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She was seen in the emergency department one month later with vesiculobullous lesions with clear content that were isolated or grouped in rosettes. Direct immunofluorescence showed baseline linear positivity for immunoglobulin A (IgA) (+) and fibrinogen-positive bullous content with absent remaining immunosera expression. The observed results were compatible with linear IgA bullous dermatosis. After confirming the diagnosis and excluding glucose-6-phosphate dehydrogenase (G6PD) deficiency, dapsone was added to the initial treatment with systemic and topical corticosteroids. This case report is a reminder of the importance of a high index of clinical suspicion for this condition to reach a timely diagnosis.</description><identifier>ISSN: 2168-8184</identifier><identifier>EISSN: 2168-8184</identifier><identifier>DOI: 10.7759/cureus.35569</identifier><identifier>PMID: 37007367</identifier><language>eng</language><publisher>United States: Cureus Inc</publisher><subject>Antibiotics ; Antibodies ; Antigens ; Blood tests ; Case reports ; Children & youth ; Dermatitis ; Dermatology ; Drug dosages ; Emergency medical care ; Hematology ; Hospitalization ; Immunoglobulins ; Neutrophils ; Pediatrics ; Skin diseases ; Steroids ; Surveillance ; Tumor necrosis factor-TNF</subject><ispartof>Curēus (Palo Alto, CA), 2023-02, Vol.15 (2), p.e35569</ispartof><rights>Copyright © 2023, Machado Morais et al.</rights><rights>Copyright © 2023, Machado Morais et al. This work is published under https://creativecommons.org/licenses/by/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Copyright © 2023, Machado Morais et al. 2023 Machado Morais et al.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c267t-7d3efe074a50bdf956647c806af563264150e767f088554af8748b048cca17183</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10061548/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10061548/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,886,27929,27930,53796,53798</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37007367$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Machado Morais, Joana</creatorcontrib><creatorcontrib>Meneses, Mariana</creatorcontrib><creatorcontrib>Freitas, Catarina</creatorcontrib><creatorcontrib>Oliveira, Herberto</creatorcontrib><creatorcontrib>Leite, Inês</creatorcontrib><title>Linear Immunoglobulin A Dermatosis: A Rare Case Illustrating Successful Treatment With Dapsone</title><title>Curēus (Palo Alto, CA)</title><addtitle>Cureus</addtitle><description>This is the case report of a previously healthy four-year-old girl with a history of upper airway infection that was treated with a β-lactam antibiotic. 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This case report is a reminder of the importance of a high index of clinical suspicion for this condition to reach a timely diagnosis.</description><subject>Antibiotics</subject><subject>Antibodies</subject><subject>Antigens</subject><subject>Blood tests</subject><subject>Case reports</subject><subject>Children & youth</subject><subject>Dermatitis</subject><subject>Dermatology</subject><subject>Drug dosages</subject><subject>Emergency medical care</subject><subject>Hematology</subject><subject>Hospitalization</subject><subject>Immunoglobulins</subject><subject>Neutrophils</subject><subject>Pediatrics</subject><subject>Skin diseases</subject><subject>Steroids</subject><subject>Surveillance</subject><subject>Tumor necrosis factor-TNF</subject><issn>2168-8184</issn><issn>2168-8184</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNpVkctLAzEQxoMoVqo3zxLwautk86wXKa2PQkHwgTdDmmbbLbubmmwE_3u3VoueZob58c3HfAidEuhLyQeXNgWXYp9yLgZ76CgjQvUUUWz_T99BJzGuAICAzEDCIepQCSCpkEfobVrUzgQ8qapU-0XpZ6ksajzEYxcq0_hYxKt2ejTB4ZGJDk_KMsUmmKaoF_gpWetizFOJn4MzTeXqBr8WzRKPzTr62h2jg9yU0Z381C56ub15Ht33pg93k9Fw2rOZkE1PzqnLHUhmOMzm-YALwaRVIEzOBc0EIxycFDIHpThnJleSqRkwZa0hkijaRddb3XWaVW5uWx_BlHodisqET-1Nof9v6mKpF_5DEwBBONsonP8oBP-eXGz0yqdQt6Z1JgeUZpQq1lIXW8oGH2Nw-e4EAb1JRG8T0d-JtPjZX1s7-Pf_9AvfBIhT</recordid><startdate>20230228</startdate><enddate>20230228</enddate><creator>Machado Morais, Joana</creator><creator>Meneses, Mariana</creator><creator>Freitas, Catarina</creator><creator>Oliveira, Herberto</creator><creator>Leite, Inês</creator><general>Cureus Inc</general><general>Cureus</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>5PM</scope></search><sort><creationdate>20230228</creationdate><title>Linear Immunoglobulin A Dermatosis: A Rare Case Illustrating Successful Treatment With Dapsone</title><author>Machado Morais, Joana ; 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| subjects | Antibiotics Antibodies Antigens Blood tests Case reports Children & youth Dermatitis Dermatology Drug dosages Emergency medical care Hematology Hospitalization Immunoglobulins Neutrophils Pediatrics Skin diseases Steroids Surveillance Tumor necrosis factor-TNF |
| title | Linear Immunoglobulin A Dermatosis: A Rare Case Illustrating Successful Treatment With Dapsone |
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