Phloretamide Prevent Hepatic and Pancreatic Damage in Diabetic Male Rats by Modulating Nrf2 and NF-κB

This study examined the effect of phloretamide, a metabolite of phloretin, on liver damage and steatosis in streptozotocin-induced diabetes mellitus (DM) in rats. Adult male rats were divided into two groups: control (nondiabetic) and STZ-treated rats, each of which was further treated orally with t...

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Veröffentlicht in:	Nutrients 2023-03, Vol.15 (6), p.1456
Hauptverfasser:	Al-Hussan, Rasha, Albadr, Nawal A, Alshammari, Ghedeir M, Almasri, Soheir A, Yahya, Mohammed Abdo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antioxidants Apoptosis Beta cells Catalase Cholesterol Complications and side effects Cytology Damage prevention Diabetes Diabetes mellitus Diabetes Mellitus, Experimental - complications Diabetes Mellitus, Experimental - drug therapy Diabetes Mellitus, Experimental - metabolism Fasting Fatty Liver Glucose Glucose - pharmacology Health aspects Heme Hexokinase Inflammation Insulin Insulins - metabolism Interleukin 6 Laboratories Lipid peroxidation Lipids Liver diseases Low density lipoprotein Male Metabolism Metabolites mRNA NF-E2-Related Factor 2 - metabolism NF-kappa B - metabolism NF-κB protein Oxidation Oxidative Stress Oxygenase Pancreas Pancreatic diseases Peroxidation Physiological aspects Polyphenols Prevention Rats Risk factors Serum levels Steatosis Streptozocin Transcription factors Triglycerides Tumor necrosis factor-α
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