Myopia Is Suppressed by Digested Lactoferrin or Holo-Lactoferrin Administration
Myopia is becoming a leading cause of vision impairment. An effective intervention is needed. Lactoferrin (LF) is a protein that has been reported to inhibit myopia progression when taken orally. This study looked at the effects of different forms of LF, such as native LF and digested LF, on myopia...
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| Veröffentlicht in: | International journal of molecular sciences 2023-03, Vol.24 (6), p.5815 |
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| creator | Liang, Yifan Ikeda, Shin-Ichi Chen, Junhan Zhang, Yan Negishi, Kazuno Tsubota, Kazuo Kurihara, Toshihide |
| description | Myopia is becoming a leading cause of vision impairment. An effective intervention is needed. Lactoferrin (LF) is a protein that has been reported to inhibit myopia progression when taken orally. This study looked at the effects of different forms of LF, such as native LF and digested LF, on myopia in mice. Mice were given different forms of LF from 3 weeks of age, and myopia was induced with minus lenses from 4 weeks of age. Results showed that mice given digested LF or holo-LF had a less elongated axial length and thinned choroid, compared to those given native-LF. Gene expression analysis also showed that the groups given native-LF and its derivatives had lower levels of certain cytokines and growth factors associated with myopia. These results suggest that myopia can be more effectively suppressed by digested LF or holo-LF than native-LF. |
| doi_str_mv | 10.3390/ijms24065815 |
| format | Article |
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An effective intervention is needed. Lactoferrin (LF) is a protein that has been reported to inhibit myopia progression when taken orally. This study looked at the effects of different forms of LF, such as native LF and digested LF, on myopia in mice. Mice were given different forms of LF from 3 weeks of age, and myopia was induced with minus lenses from 4 weeks of age. Results showed that mice given digested LF or holo-LF had a less elongated axial length and thinned choroid, compared to those given native-LF. Gene expression analysis also showed that the groups given native-LF and its derivatives had lower levels of certain cytokines and growth factors associated with myopia. These results suggest that myopia can be more effectively suppressed by digested LF or holo-LF than native-LF.</description><identifier>ISSN: 1422-0067</identifier><identifier>ISSN: 1661-6596</identifier><identifier>EISSN: 1422-0067</identifier><identifier>DOI: 10.3390/ijms24065815</identifier><identifier>PMID: 36982888</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Animals ; Comparative analysis ; Cytokines ; Gene expression ; Glycoproteins ; Growth factors ; Inflammation ; Iron ; Lactoferrin ; Lactoferrin - metabolism ; Lactoferrin - pharmacology ; Lactoferrins ; Mice ; Myopia ; Oral administration ; Tumor necrosis factor-TNF ; Vascular endothelial growth factor ; Visual impairment</subject><ispartof>International journal of molecular sciences, 2023-03, Vol.24 (6), p.5815</ispartof><rights>COPYRIGHT 2023 MDPI AG</rights><rights>2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). 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An effective intervention is needed. Lactoferrin (LF) is a protein that has been reported to inhibit myopia progression when taken orally. This study looked at the effects of different forms of LF, such as native LF and digested LF, on myopia in mice. Mice were given different forms of LF from 3 weeks of age, and myopia was induced with minus lenses from 4 weeks of age. Results showed that mice given digested LF or holo-LF had a less elongated axial length and thinned choroid, compared to those given native-LF. Gene expression analysis also showed that the groups given native-LF and its derivatives had lower levels of certain cytokines and growth factors associated with myopia. 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| subjects | Animals Comparative analysis Cytokines Gene expression Glycoproteins Growth factors Inflammation Iron Lactoferrin Lactoferrin - metabolism Lactoferrin - pharmacology Lactoferrins Mice Myopia Oral administration Tumor necrosis factor-TNF Vascular endothelial growth factor Visual impairment |
| title | Myopia Is Suppressed by Digested Lactoferrin or Holo-Lactoferrin Administration |
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