Distribution of OGTT-Related Variables in Patients with Cystic Fibrosis from Puberty to Adulthood: An Italian Multicenter Study
Insulin secretion and glucose tolerance is annually assessed in patients with cystic fibrosis (PwCF) through oral glucose tolerance tests (OGTTs) as a screening measure for cystic fibrosis-related diabetes. We aimed to describe the distribution and provide reference quartiles of OGTT-related variabl...
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| Veröffentlicht in: | Journal of personalized medicine 2023-03, Vol.13 (3), p.469 |
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| creator | Foppiani, Andrea Ciciriello, Fabiana Bisogno, Arianna Bricchi, Silvia Colombo, Carla Alghisi, Federico Lucidi, Vincenzina Catena, Maria Ausilia Lucanto, Mariacristina Mari, Andrea Bedogni, Giorgio Battezzati, Alberto |
| description | Insulin secretion and glucose tolerance is annually assessed in patients with cystic fibrosis (PwCF) through oral glucose tolerance tests (OGTTs) as a screening measure for cystic fibrosis-related diabetes. We aimed to describe the distribution and provide reference quartiles of OGTT-related variables in the Italian cystic fibrosis population.
Cross-sectional study of PwCF receiving care in three Italian cystic fibrosis centers of excellence, from 2016 to 2020. We performed a modified 2-h OGTT protocol (1.75 g/kg, maximum 75 g), sampling at baseline and at 30-min intervals, analyzing plasma glucose, serum insulin, and C-peptide. The modified OGTT allowed for the modeling of β cell function. For all variables, multivariable quantile regression was performed to estimate the median, the 25th, and 75th percentiles, with age, sex, and pancreatic insufficiency as predictors.
We have quantified the deterioration of glucose tolerance and insulin secretion with age according to sex and pancreatic insufficiency, highlighting a deviation from linearity both for patients 35 years of age.
References of OGTT variables for PwCF provide a necessary tool to not only identify patients at risk for CFRD or other cystic fibrosis-related complications, but also to evaluate the effects of promising pharmacological therapies. |
| doi_str_mv | 10.3390/jpm13030469 |
| format | Article |
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Cross-sectional study of PwCF receiving care in three Italian cystic fibrosis centers of excellence, from 2016 to 2020. We performed a modified 2-h OGTT protocol (1.75 g/kg, maximum 75 g), sampling at baseline and at 30-min intervals, analyzing plasma glucose, serum insulin, and C-peptide. The modified OGTT allowed for the modeling of β cell function. For all variables, multivariable quantile regression was performed to estimate the median, the 25th, and 75th percentiles, with age, sex, and pancreatic insufficiency as predictors.
We have quantified the deterioration of glucose tolerance and insulin secretion with age according to sex and pancreatic insufficiency, highlighting a deviation from linearity both for patients <10 years and >35 years of age.
References of OGTT variables for PwCF provide a necessary tool to not only identify patients at risk for CFRD or other cystic fibrosis-related complications, but also to evaluate the effects of promising pharmacological therapies.</description><identifier>ISSN: 2075-4426</identifier><identifier>EISSN: 2075-4426</identifier><identifier>DOI: 10.3390/jpm13030469</identifier><identifier>PMID: 36983651</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Adults ; Age ; Analysis ; Beta cells ; Body mass index ; Care and treatment ; Chromium ; Cystic fibrosis ; Dextrose ; Diabetes ; Diabetes mellitus ; Glucose ; Glucose tolerance ; Glucose tolerance tests ; Hyperglycemia ; Insulin ; Insulin secretion ; Ivacaftor ; Medical research ; Medicine, Experimental ; Mutation ; Nutritional status ; Pancreas ; Peptides ; Plasma ; Population studies ; Precision medicine ; Puberty ; Secretion</subject><ispartof>Journal of personalized medicine, 2023-03, Vol.13 (3), p.469</ispartof><rights>COPYRIGHT 2023 MDPI AG</rights><rights>2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2023 by the authors. 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c435t-3a805545e0a26d3ce8e726ff264abdc0357776b7de90a92c4b6b3a5c1ec6b2063</cites><orcidid>0009-0004-0699-0911 ; 0000-0002-4333-791X ; 0000-0002-8975-695X ; 0000-0002-1495-9306 ; 0000-0003-1493-9767 ; 0000-0003-2803-7713</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10056682/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10056682/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27923,27924,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36983651$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Foppiani, Andrea</creatorcontrib><creatorcontrib>Ciciriello, Fabiana</creatorcontrib><creatorcontrib>Bisogno, Arianna</creatorcontrib><creatorcontrib>Bricchi, Silvia</creatorcontrib><creatorcontrib>Colombo, Carla</creatorcontrib><creatorcontrib>Alghisi, Federico</creatorcontrib><creatorcontrib>Lucidi, Vincenzina</creatorcontrib><creatorcontrib>Catena, Maria Ausilia</creatorcontrib><creatorcontrib>Lucanto, Mariacristina</creatorcontrib><creatorcontrib>Mari, Andrea</creatorcontrib><creatorcontrib>Bedogni, Giorgio</creatorcontrib><creatorcontrib>Battezzati, Alberto</creatorcontrib><title>Distribution of OGTT-Related Variables in Patients with Cystic Fibrosis from Puberty to Adulthood: An Italian Multicenter Study</title><title>Journal of personalized medicine</title><addtitle>J Pers Med</addtitle><description>Insulin secretion and glucose tolerance is annually assessed in patients with cystic fibrosis (PwCF) through oral glucose tolerance tests (OGTTs) as a screening measure for cystic fibrosis-related diabetes. We aimed to describe the distribution and provide reference quartiles of OGTT-related variables in the Italian cystic fibrosis population.
Cross-sectional study of PwCF receiving care in three Italian cystic fibrosis centers of excellence, from 2016 to 2020. We performed a modified 2-h OGTT protocol (1.75 g/kg, maximum 75 g), sampling at baseline and at 30-min intervals, analyzing plasma glucose, serum insulin, and C-peptide. The modified OGTT allowed for the modeling of β cell function. For all variables, multivariable quantile regression was performed to estimate the median, the 25th, and 75th percentiles, with age, sex, and pancreatic insufficiency as predictors.
We have quantified the deterioration of glucose tolerance and insulin secretion with age according to sex and pancreatic insufficiency, highlighting a deviation from linearity both for patients <10 years and >35 years of age.
References of OGTT variables for PwCF provide a necessary tool to not only identify patients at risk for CFRD or other cystic fibrosis-related complications, but also to evaluate the effects of promising pharmacological therapies.</description><subject>Adults</subject><subject>Age</subject><subject>Analysis</subject><subject>Beta cells</subject><subject>Body mass index</subject><subject>Care and treatment</subject><subject>Chromium</subject><subject>Cystic fibrosis</subject><subject>Dextrose</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Glucose</subject><subject>Glucose tolerance</subject><subject>Glucose tolerance tests</subject><subject>Hyperglycemia</subject><subject>Insulin</subject><subject>Insulin secretion</subject><subject>Ivacaftor</subject><subject>Medical research</subject><subject>Medicine, Experimental</subject><subject>Mutation</subject><subject>Nutritional status</subject><subject>Pancreas</subject><subject>Peptides</subject><subject>Plasma</subject><subject>Population studies</subject><subject>Precision medicine</subject><subject>Puberty</subject><subject>Secretion</subject><issn>2075-4426</issn><issn>2075-4426</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNptksFvFCEUxidGY5vak3dD4sXEbGVgYGa8mM1qa5OaNrp6JcC86b7NDGyB0ezJf102rZutEQ6Qx-998HhfUbws6RnnLX233owlp5xWsn1SHDNai1lVMfn0YH9UnMa4pnk0gjFJnxdHXLYNl6I8Ln5_xJgCmimhd8T35PpiuZx9hUEn6MgPHVCbASJBR250QnApkl-YVmSxjQktOUcTfMRI-uBHcjMZCGlLkifzbhrSyvvuPZk7cpn0gNqRLzmINqtAIN_S1G1fFM96PUQ4fVhPiu_nn5aLz7Or64vLxfxqZisu0ozrhgpRCaCayY5baKBmsu-ZrLTpLOWirmtp6g5aqltmKyMN18KWYKVhVPKT4sO97mYyI3S7JwQ9qE3AUYet8hrV4xOHK3Xrf6qSUiFlw7LCmweF4O8miEmNGC0Mg3bgp6hY3TJBW97QjL7-B137Kbhc344qpWjqDO6pWz2AQtf7fLHdiap5nTvVtkLyTJ39h8qzgxGtd9Bjjj9KeHufYHNjYoB-X2RJ1c4z6sAzmX51-C979q9D-B_BNbxV</recordid><startdate>20230303</startdate><enddate>20230303</enddate><creator>Foppiani, Andrea</creator><creator>Ciciriello, Fabiana</creator><creator>Bisogno, Arianna</creator><creator>Bricchi, Silvia</creator><creator>Colombo, Carla</creator><creator>Alghisi, Federico</creator><creator>Lucidi, Vincenzina</creator><creator>Catena, Maria Ausilia</creator><creator>Lucanto, Mariacristina</creator><creator>Mari, Andrea</creator><creator>Bedogni, Giorgio</creator><creator>Battezzati, Alberto</creator><general>MDPI AG</general><general>MDPI</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FE</scope><scope>8FH</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0009-0004-0699-0911</orcidid><orcidid>https://orcid.org/0000-0002-4333-791X</orcidid><orcidid>https://orcid.org/0000-0002-8975-695X</orcidid><orcidid>https://orcid.org/0000-0002-1495-9306</orcidid><orcidid>https://orcid.org/0000-0003-1493-9767</orcidid><orcidid>https://orcid.org/0000-0003-2803-7713</orcidid></search><sort><creationdate>20230303</creationdate><title>Distribution of OGTT-Related Variables in Patients with Cystic Fibrosis from Puberty to Adulthood: An Italian Multicenter Study</title><author>Foppiani, Andrea ; Ciciriello, Fabiana ; Bisogno, Arianna ; Bricchi, Silvia ; Colombo, Carla ; Alghisi, Federico ; Lucidi, Vincenzina ; Catena, Maria Ausilia ; Lucanto, Mariacristina ; Mari, Andrea ; Bedogni, Giorgio ; Battezzati, Alberto</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c435t-3a805545e0a26d3ce8e726ff264abdc0357776b7de90a92c4b6b3a5c1ec6b2063</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Adults</topic><topic>Age</topic><topic>Analysis</topic><topic>Beta cells</topic><topic>Body mass index</topic><topic>Care and treatment</topic><topic>Chromium</topic><topic>Cystic fibrosis</topic><topic>Dextrose</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>Glucose</topic><topic>Glucose tolerance</topic><topic>Glucose tolerance tests</topic><topic>Hyperglycemia</topic><topic>Insulin</topic><topic>Insulin secretion</topic><topic>Ivacaftor</topic><topic>Medical research</topic><topic>Medicine, Experimental</topic><topic>Mutation</topic><topic>Nutritional status</topic><topic>Pancreas</topic><topic>Peptides</topic><topic>Plasma</topic><topic>Population studies</topic><topic>Precision medicine</topic><topic>Puberty</topic><topic>Secretion</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Foppiani, Andrea</creatorcontrib><creatorcontrib>Ciciriello, Fabiana</creatorcontrib><creatorcontrib>Bisogno, Arianna</creatorcontrib><creatorcontrib>Bricchi, Silvia</creatorcontrib><creatorcontrib>Colombo, Carla</creatorcontrib><creatorcontrib>Alghisi, Federico</creatorcontrib><creatorcontrib>Lucidi, Vincenzina</creatorcontrib><creatorcontrib>Catena, Maria Ausilia</creatorcontrib><creatorcontrib>Lucanto, Mariacristina</creatorcontrib><creatorcontrib>Mari, Andrea</creatorcontrib><creatorcontrib>Bedogni, Giorgio</creatorcontrib><creatorcontrib>Battezzati, Alberto</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of personalized medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Foppiani, Andrea</au><au>Ciciriello, Fabiana</au><au>Bisogno, Arianna</au><au>Bricchi, Silvia</au><au>Colombo, Carla</au><au>Alghisi, Federico</au><au>Lucidi, Vincenzina</au><au>Catena, Maria Ausilia</au><au>Lucanto, Mariacristina</au><au>Mari, Andrea</au><au>Bedogni, Giorgio</au><au>Battezzati, Alberto</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Distribution of OGTT-Related Variables in Patients with Cystic Fibrosis from Puberty to Adulthood: An Italian Multicenter Study</atitle><jtitle>Journal of personalized medicine</jtitle><addtitle>J Pers Med</addtitle><date>2023-03-03</date><risdate>2023</risdate><volume>13</volume><issue>3</issue><spage>469</spage><pages>469-</pages><issn>2075-4426</issn><eissn>2075-4426</eissn><abstract>Insulin secretion and glucose tolerance is annually assessed in patients with cystic fibrosis (PwCF) through oral glucose tolerance tests (OGTTs) as a screening measure for cystic fibrosis-related diabetes. We aimed to describe the distribution and provide reference quartiles of OGTT-related variables in the Italian cystic fibrosis population.
Cross-sectional study of PwCF receiving care in three Italian cystic fibrosis centers of excellence, from 2016 to 2020. We performed a modified 2-h OGTT protocol (1.75 g/kg, maximum 75 g), sampling at baseline and at 30-min intervals, analyzing plasma glucose, serum insulin, and C-peptide. The modified OGTT allowed for the modeling of β cell function. For all variables, multivariable quantile regression was performed to estimate the median, the 25th, and 75th percentiles, with age, sex, and pancreatic insufficiency as predictors.
We have quantified the deterioration of glucose tolerance and insulin secretion with age according to sex and pancreatic insufficiency, highlighting a deviation from linearity both for patients <10 years and >35 years of age.
References of OGTT variables for PwCF provide a necessary tool to not only identify patients at risk for CFRD or other cystic fibrosis-related complications, but also to evaluate the effects of promising pharmacological therapies.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>36983651</pmid><doi>10.3390/jpm13030469</doi><orcidid>https://orcid.org/0009-0004-0699-0911</orcidid><orcidid>https://orcid.org/0000-0002-4333-791X</orcidid><orcidid>https://orcid.org/0000-0002-8975-695X</orcidid><orcidid>https://orcid.org/0000-0002-1495-9306</orcidid><orcidid>https://orcid.org/0000-0003-1493-9767</orcidid><orcidid>https://orcid.org/0000-0003-2803-7713</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adults Age Analysis Beta cells Body mass index Care and treatment Chromium Cystic fibrosis Dextrose Diabetes Diabetes mellitus Glucose Glucose tolerance Glucose tolerance tests Hyperglycemia Insulin Insulin secretion Ivacaftor Medical research Medicine, Experimental Mutation Nutritional status Pancreas Peptides Plasma Population studies Precision medicine Puberty Secretion |
| title | Distribution of OGTT-Related Variables in Patients with Cystic Fibrosis from Puberty to Adulthood: An Italian Multicenter Study |
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