Ellagitannins from Castanea sativa Mill. Leaf Extracts Impair H. pylori Viability and Infection-Induced Inflammation in Human Gastric Epithelial Cells

( ) is an etiologic factor of peptic ulcer disease and gastric cancer. Virulent strains of are correlated with the severity of gastritis, due to NF-κB activation and IL-8 expression at the epithelial level. Ellagitannins have been documented for antibacterial and anti-inflammatory activities, thus s...

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Veröffentlicht in:	Nutrients 2023-03, Vol.15 (6), p.1504
Hauptverfasser:	Piazza, Stefano, Martinelli, Giulia, Fumagalli, Marco, Pozzoli, Carola, Maranta, Nicole, Giavarini, Flavio, Colombo, Luca, Nicotra, Giovanna, Vicentini, Silvia Francesca, Genova, Francesca, De Fabiani, Emma, Sangiovanni, Enrico, Dell'Agli, Mario
Format:	Artikel
Sprache:	eng
Schlagworte:	Agricultural wastes Anti-inflammatory agents Anti-Inflammatory Agents - therapeutic use Bioactive compounds Biological activity Castanea sativa Cell adhesion Cell culture Chemokines Chestnut Epithelial cells Epithelial Cells - metabolism Epithelium Ethanol Gastric cancer Gastric Mucosa - metabolism Gastritis Gastritis - microbiology Helicobacter Infections - microbiology Helicobacter pylori Humans Hydrolyzable Tannins - metabolism Infections Inflammation Inflammation - drug therapy Inflammation - metabolism Interleukin 8 Interleukin-8 - metabolism Investigations Isomers Leaves Life sciences Neutrophils NF-kappa B - metabolism NF-κB protein Oral administration Peptic ulcers Plant extracts Plant Extracts - therapeutic use Polyphenols Reagents Transcription factors Ulcers
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