In vivo protection against interleukin-1-induced articular cartilage damage by transforming growth factor-beta 1: age-related differences

OBJECTIVES--Transforming growth factor-beta (TGF-beta) has been shown to antagonise interleukin-1 (IL-1) effects in different systems. Investigations were carried out to study whether TGF-beta 1 modulates IL-1 induced inflammation and IL-1 effects on articular cartilage in the murine knee joint. MET...

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Veröffentlicht in:	Annals of the rheumatic diseases 1994-09, Vol.53 (9), p.593-600
Hauptverfasser:	van Beuningen, H M, van der Kraan, P M, Arntz, O J, van den Berg, W B
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Factors Animals Cartilage, Articular - metabolism Drug Synergism Interleukin-1 - antagonists & inhibitors Interleukin-1 - pharmacology Male Mice Mice, Inbred C57BL Patella - metabolism Proteoglycans - metabolism Recombinant Proteins - pharmacology Synovitis - etiology Transforming Growth Factor beta - pharmacology
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