In vivo protection against interleukin-1-induced articular cartilage damage by transforming growth factor-beta 1: age-related differences
OBJECTIVES--Transforming growth factor-beta (TGF-beta) has been shown to antagonise interleukin-1 (IL-1) effects in different systems. Investigations were carried out to study whether TGF-beta 1 modulates IL-1 induced inflammation and IL-1 effects on articular cartilage in the murine knee joint. MET...
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| Veröffentlicht in: | Annals of the rheumatic diseases 1994-09, Vol.53 (9), p.593-600 |
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| creator | van Beuningen, H M van der Kraan, P M Arntz, O J van den Berg, W B |
| description | OBJECTIVES--Transforming growth factor-beta (TGF-beta) has been shown to antagonise interleukin-1 (IL-1) effects in different systems. Investigations were carried out to study whether TGF-beta 1 modulates IL-1 induced inflammation and IL-1 effects on articular cartilage in the murine knee joint. METHODS--IL-1, TGF-beta 1 or both factors together were injected into the knee joint. Inflammation was studied in whole knee histological sections. Patellar cartilage proteoglycan synthesis was measured using 35S-sulphate incorporation while patellar cartilage glycosaminoglycan content was determined with automated image analysis on joint sections. RESULTS--Co-injection of TGF-beta 1 and IL-1 resulted in synergistic attraction of inflammatory cells. In contrast, TGF-beta 1 counteracted IL-1 induced suppression of articular cartilage proteoglycan synthesis. Proteoglycan depletion was similar shortly after the last injection of IL-1 or IL-1/TGF-beta 1, but accelerated recovery was found with the combination at later days. This protective effect of TGF-beta 1 could not be demonstrated in older mice. CONCLUSIONS--TGF-beta 1 aggravates IL-1 induced knee joint inflammation, but counteracts the deleterious effects of IL-1 on articular cartilage proteoglycan synthesis and content. The data indicate that TGF-beta 1 could play an important part in articular cartilage restoration after IL-1 induced proteoglycan depletion. |
| doi_str_mv | 10.1136/ard.53.9.593 |
| format | Article |
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Investigations were carried out to study whether TGF-beta 1 modulates IL-1 induced inflammation and IL-1 effects on articular cartilage in the murine knee joint. METHODS--IL-1, TGF-beta 1 or both factors together were injected into the knee joint. Inflammation was studied in whole knee histological sections. Patellar cartilage proteoglycan synthesis was measured using 35S-sulphate incorporation while patellar cartilage glycosaminoglycan content was determined with automated image analysis on joint sections. RESULTS--Co-injection of TGF-beta 1 and IL-1 resulted in synergistic attraction of inflammatory cells. In contrast, TGF-beta 1 counteracted IL-1 induced suppression of articular cartilage proteoglycan synthesis. Proteoglycan depletion was similar shortly after the last injection of IL-1 or IL-1/TGF-beta 1, but accelerated recovery was found with the combination at later days. This protective effect of TGF-beta 1 could not be demonstrated in older mice. CONCLUSIONS--TGF-beta 1 aggravates IL-1 induced knee joint inflammation, but counteracts the deleterious effects of IL-1 on articular cartilage proteoglycan synthesis and content. The data indicate that TGF-beta 1 could play an important part in articular cartilage restoration after IL-1 induced proteoglycan depletion.</description><identifier>ISSN: 0003-4967</identifier><identifier>EISSN: 1468-2060</identifier><identifier>DOI: 10.1136/ard.53.9.593</identifier><identifier>PMID: 7979598</identifier><identifier>CODEN: ARDIAO</identifier><language>eng</language><publisher>England: BMJ Publishing Group Ltd and European League Against Rheumatism</publisher><subject>Age Factors ; Animals ; Cartilage, Articular - metabolism ; Drug Synergism ; Interleukin-1 - antagonists & inhibitors ; Interleukin-1 - pharmacology ; Male ; Mice ; Mice, Inbred C57BL ; Patella - metabolism ; Proteoglycans - metabolism ; Recombinant Proteins - pharmacology ; Synovitis - etiology ; Transforming Growth Factor beta - pharmacology</subject><ispartof>Annals of the rheumatic diseases, 1994-09, Vol.53 (9), p.593-600</ispartof><rights>Copyright BMJ Publishing Group LTD Sep 1994</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b3243-62bfadb2b15ae2be99ad55dfaaf40008cb6551448b329b3a51ff69fa5766cba03</citedby><cites>FETCH-LOGICAL-b3243-62bfadb2b15ae2be99ad55dfaaf40008cb6551448b329b3a51ff69fa5766cba03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1005411/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1005411/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7979598$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>van Beuningen, H M</creatorcontrib><creatorcontrib>van der Kraan, P M</creatorcontrib><creatorcontrib>Arntz, O J</creatorcontrib><creatorcontrib>van den Berg, W B</creatorcontrib><title>In vivo protection against interleukin-1-induced articular cartilage damage by transforming growth factor-beta 1: age-related differences</title><title>Annals of the rheumatic diseases</title><addtitle>Ann Rheum Dis</addtitle><description>OBJECTIVES--Transforming growth factor-beta (TGF-beta) has been shown to antagonise interleukin-1 (IL-1) effects in different systems. Investigations were carried out to study whether TGF-beta 1 modulates IL-1 induced inflammation and IL-1 effects on articular cartilage in the murine knee joint. METHODS--IL-1, TGF-beta 1 or both factors together were injected into the knee joint. Inflammation was studied in whole knee histological sections. Patellar cartilage proteoglycan synthesis was measured using 35S-sulphate incorporation while patellar cartilage glycosaminoglycan content was determined with automated image analysis on joint sections. RESULTS--Co-injection of TGF-beta 1 and IL-1 resulted in synergistic attraction of inflammatory cells. In contrast, TGF-beta 1 counteracted IL-1 induced suppression of articular cartilage proteoglycan synthesis. Proteoglycan depletion was similar shortly after the last injection of IL-1 or IL-1/TGF-beta 1, but accelerated recovery was found with the combination at later days. This protective effect of TGF-beta 1 could not be demonstrated in older mice. CONCLUSIONS--TGF-beta 1 aggravates IL-1 induced knee joint inflammation, but counteracts the deleterious effects of IL-1 on articular cartilage proteoglycan synthesis and content. The data indicate that TGF-beta 1 could play an important part in articular cartilage restoration after IL-1 induced proteoglycan depletion.</description><subject>Age Factors</subject><subject>Animals</subject><subject>Cartilage, Articular - metabolism</subject><subject>Drug Synergism</subject><subject>Interleukin-1 - antagonists & inhibitors</subject><subject>Interleukin-1 - pharmacology</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Patella - metabolism</subject><subject>Proteoglycans - metabolism</subject><subject>Recombinant Proteins - pharmacology</subject><subject>Synovitis - etiology</subject><subject>Transforming Growth Factor beta - pharmacology</subject><issn>0003-4967</issn><issn>1468-2060</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kcGL1DAYxYMo6zh68yoEPHixY9I2aeNBkMFZFxZFUBEv4UuadDPbJmOaju6f4H9thhkGvXj6Et6P973kIfSUkhWlFX8FsVuxaiVWTFT30ILWvC1Kwsl9tCCEVEUtePMQPZqmbb6SlrYX6KIRjWCiXaDfVx7v3T7gXQzJ6OSCx9CD81PCzicTBzPfOl_Qwvlu1qbDEJPT8wAR68NxgN7gDsbDUHc4RfCTDXF0vsd9DD_TDbagU4iFMgkwfZ3tTRHNACmbdc5aE43XZnqMHlgYJvPkNJfoy-bd5_X74vrj5dX67XWhqrKuCl4qC50qFWVgSmWEgI6xzgLY-vA8rThjtK7bjAtVAaPWcmGBNZxrBaRaojdH392sRtNp43PmQe6iGyHeyQBO_qt4dyP7sJeUEFbnH1-i5yeDGH7MZkpyG-boc2ZJGy6aqix5k6mXR0rHME3R2PMGSuShN5l7k6ySQubeMv7s71Rn-FRU1ouj7qZkfp1liLcyL2uY_PB1LTefmsvv4huVm8y_OPJq3P5_8x8a8LOm</recordid><startdate>199409</startdate><enddate>199409</enddate><creator>van Beuningen, H M</creator><creator>van der Kraan, P M</creator><creator>Arntz, O J</creator><creator>van den Berg, W B</creator><general>BMJ Publishing Group Ltd and European League Against Rheumatism</general><general>Elsevier Limited</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>LK8</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>5PM</scope></search><sort><creationdate>199409</creationdate><title>In vivo protection against interleukin-1-induced articular cartilage damage by transforming growth factor-beta 1: age-related differences</title><author>van Beuningen, H M ; van der Kraan, P M ; Arntz, O J ; van den Berg, W B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b3243-62bfadb2b15ae2be99ad55dfaaf40008cb6551448b329b3a51ff69fa5766cba03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Age Factors</topic><topic>Animals</topic><topic>Cartilage, Articular - metabolism</topic><topic>Drug Synergism</topic><topic>Interleukin-1 - antagonists & inhibitors</topic><topic>Interleukin-1 - pharmacology</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Patella - metabolism</topic><topic>Proteoglycans - metabolism</topic><topic>Recombinant Proteins - pharmacology</topic><topic>Synovitis - etiology</topic><topic>Transforming Growth Factor beta - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>van Beuningen, H M</creatorcontrib><creatorcontrib>van der Kraan, P M</creatorcontrib><creatorcontrib>Arntz, O J</creatorcontrib><creatorcontrib>van den Berg, W B</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Annals of the rheumatic diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>van Beuningen, H M</au><au>van der Kraan, P M</au><au>Arntz, O J</au><au>van den Berg, W B</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>In vivo protection against interleukin-1-induced articular cartilage damage by transforming growth factor-beta 1: age-related differences</atitle><jtitle>Annals of the rheumatic diseases</jtitle><addtitle>Ann Rheum Dis</addtitle><date>1994-09</date><risdate>1994</risdate><volume>53</volume><issue>9</issue><spage>593</spage><epage>600</epage><pages>593-600</pages><issn>0003-4967</issn><eissn>1468-2060</eissn><coden>ARDIAO</coden><abstract>OBJECTIVES--Transforming growth factor-beta (TGF-beta) has been shown to antagonise interleukin-1 (IL-1) effects in different systems. Investigations were carried out to study whether TGF-beta 1 modulates IL-1 induced inflammation and IL-1 effects on articular cartilage in the murine knee joint. METHODS--IL-1, TGF-beta 1 or both factors together were injected into the knee joint. Inflammation was studied in whole knee histological sections. Patellar cartilage proteoglycan synthesis was measured using 35S-sulphate incorporation while patellar cartilage glycosaminoglycan content was determined with automated image analysis on joint sections. RESULTS--Co-injection of TGF-beta 1 and IL-1 resulted in synergistic attraction of inflammatory cells. In contrast, TGF-beta 1 counteracted IL-1 induced suppression of articular cartilage proteoglycan synthesis. Proteoglycan depletion was similar shortly after the last injection of IL-1 or IL-1/TGF-beta 1, but accelerated recovery was found with the combination at later days. This protective effect of TGF-beta 1 could not be demonstrated in older mice. CONCLUSIONS--TGF-beta 1 aggravates IL-1 induced knee joint inflammation, but counteracts the deleterious effects of IL-1 on articular cartilage proteoglycan synthesis and content. The data indicate that TGF-beta 1 could play an important part in articular cartilage restoration after IL-1 induced proteoglycan depletion.</abstract><cop>England</cop><pub>BMJ Publishing Group Ltd and European League Against Rheumatism</pub><pmid>7979598</pmid><doi>10.1136/ard.53.9.593</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Annals of the rheumatic diseases, 1994-09, Vol.53 (9), p.593-600 |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Age Factors Animals Cartilage, Articular - metabolism Drug Synergism Interleukin-1 - antagonists & inhibitors Interleukin-1 - pharmacology Male Mice Mice, Inbred C57BL Patella - metabolism Proteoglycans - metabolism Recombinant Proteins - pharmacology Synovitis - etiology Transforming Growth Factor beta - pharmacology |
| title | In vivo protection against interleukin-1-induced articular cartilage damage by transforming growth factor-beta 1: age-related differences |
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