Flotillin-Dependent Membrane Microdomains Are Required for Functional Phagolysosomes against Fungal Infections

Lipid rafts form signaling platforms on biological membranes with incompletely characterized role in immune response to infection. Here we report that lipid-raft microdomains are essential components of phagolysosomal membranes of macrophages and depend on flotillins. Genetic deletion of flotillins...

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Veröffentlicht in:	Cell reports (Cambridge) 2020-08, Vol.32 (7), p.108017-108017, Article 108017
Hauptverfasser:	Schmidt, Franziska, Thywißen, Andreas, Goldmann, Marie, Cunha, Cristina, Cseresnyés, Zoltán, Schmidt, Hella, Rafiq, Muhammad, Galiani, Silvia, Gräler, Markus H., Chamilos, Georgios, Lacerda, João F., Campos, António, Eggeling, Christian, Figge, Marc Thilo, Heinekamp, Thorsten, Filler, Scott G., Carvalho, Agostinho, Brakhage, Axel A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aspergillus fumigatus calcium signaling conidial melanin flotillin fungal pathogenesis Humans macrophage membrane microdomains Membrane Microdomains - metabolism Membrane Proteins - pharmacology Membrane Proteins - therapeutic use Mycoses - drug therapy NADPH oxidase phagolysosome Phagosomes - metabolism vATPase
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