Sodium-Polystyrene Sulfonate-Induced Colitis

[...]a recent systematic review and meta-analysis showed that, although there was a statistically significantly increased risk for the composite outcome of severe gastrointestinal side effects based on 2 studies, there was no definite association of SPS use with intestinal necrosis [3]. In rats, SPS enema was associated with colonic necrosis and a high mortality rate [4]. Because intestinal necrosis is a life-threatening condition, caution should be exercised before prescribing SPS in patients at risk for complications [5]. [...]SPS-induced colitis is a rare cause of diarrhea in the hospital setting.