Malignant lesions of the caruncle
Caruncle malignancy is rare, but signs of disease can be easily missed by both patients and clinicians. There is significant potential for significant morbidity and even mortality from delayed diagnosis and treatment. Clinical features of primary malignant cancer include rapid growth, pigment deposi...
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Veröffentlicht in: | Eye (London) 2023-04, Vol.37 (5), p.849-857 |
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description | Caruncle malignancy is rare, but signs of disease can be easily missed by both patients and clinicians. There is significant potential for significant morbidity and even mortality from delayed diagnosis and treatment. Clinical features of primary malignant cancer include rapid growth, pigment deposition, ulcerated surface and bleeding. Malignant diagnoses include lymphoproliferative disease, basal cell carcinoma, squamous cell carcinoma, sebaceous carcinoma and malignant melanoma. Increased pigmentation is associated with melanoma, yellow coloured deposition with sebaceous carcinoma and a salmon-pink hue with lymphoproliferative disease. Treatment involves excision with margin control which may necessitate exenteration. Metastases to cervical and preauricular lymph nodes has been reported. |
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There is significant potential for significant morbidity and even mortality from delayed diagnosis and treatment. Clinical features of primary malignant cancer include rapid growth, pigment deposition, ulcerated surface and bleeding. Malignant diagnoses include lymphoproliferative disease, basal cell carcinoma, squamous cell carcinoma, sebaceous carcinoma and malignant melanoma. Increased pigmentation is associated with melanoma, yellow coloured deposition with sebaceous carcinoma and a salmon-pink hue with lymphoproliferative disease. Treatment involves excision with margin control which may necessitate exenteration. Metastases to cervical and preauricular lymph nodes has been reported.</description><identifier>ISSN: 0950-222X</identifier><identifier>EISSN: 1476-5454</identifier><identifier>DOI: 10.1038/s41433-022-02124-0</identifier><identifier>PMID: 35729271</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>692/1807/1482 ; 692/699 ; Adenocarcinoma, Sebaceous - pathology ; Basal cell carcinoma ; Biopsy ; Carcinoma, Basal Cell - pathology ; Cell growth ; Chemotherapy ; Humans ; Hyperplasia ; Immunoproliferative diseases ; Laboratory Medicine ; Lymph nodes ; Lymphatic system ; Lymphocytes ; Lymphoma ; Malignancy ; Medical diagnosis ; Medicine ; Medicine & Public Health ; Melanoma ; Melanoma - diagnosis ; Melanoma - pathology ; Melanoma - surgery ; Metastases ; Morbidity ; Mortality ; Ophthalmology ; Pharmaceutical Sciences/Technology ; Pigmentation ; Radiation therapy ; Review ; Review Article ; Sebaceous Gland Neoplasms - surgery ; Skin cancer ; Skin Neoplasms - diagnosis ; Skin Neoplasms - pathology ; Skin Neoplasms - surgery ; Squamous cell carcinoma ; Surgery ; Surgical Oncology</subject><ispartof>Eye (London), 2023-04, Vol.37 (5), p.849-857</ispartof><rights>Crown 2022</rights><rights>2022. 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There is significant potential for significant morbidity and even mortality from delayed diagnosis and treatment. Clinical features of primary malignant cancer include rapid growth, pigment deposition, ulcerated surface and bleeding. Malignant diagnoses include lymphoproliferative disease, basal cell carcinoma, squamous cell carcinoma, sebaceous carcinoma and malignant melanoma. Increased pigmentation is associated with melanoma, yellow coloured deposition with sebaceous carcinoma and a salmon-pink hue with lymphoproliferative disease. Treatment involves excision with margin control which may necessitate exenteration. Metastases to cervical and preauricular lymph nodes has been reported.</description><subject>692/1807/1482</subject><subject>692/699</subject><subject>Adenocarcinoma, Sebaceous - pathology</subject><subject>Basal cell carcinoma</subject><subject>Biopsy</subject><subject>Carcinoma, Basal Cell - pathology</subject><subject>Cell growth</subject><subject>Chemotherapy</subject><subject>Humans</subject><subject>Hyperplasia</subject><subject>Immunoproliferative diseases</subject><subject>Laboratory Medicine</subject><subject>Lymph nodes</subject><subject>Lymphatic system</subject><subject>Lymphocytes</subject><subject>Lymphoma</subject><subject>Malignancy</subject><subject>Medical diagnosis</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Melanoma</subject><subject>Melanoma - diagnosis</subject><subject>Melanoma - pathology</subject><subject>Melanoma - surgery</subject><subject>Metastases</subject><subject>Morbidity</subject><subject>Mortality</subject><subject>Ophthalmology</subject><subject>Pharmaceutical Sciences/Technology</subject><subject>Pigmentation</subject><subject>Radiation therapy</subject><subject>Review</subject><subject>Review Article</subject><subject>Sebaceous Gland Neoplasms - surgery</subject><subject>Skin cancer</subject><subject>Skin Neoplasms - diagnosis</subject><subject>Skin Neoplasms - pathology</subject><subject>Skin Neoplasms - surgery</subject><subject>Squamous cell carcinoma</subject><subject>Surgery</subject><subject>Surgical Oncology</subject><issn>0950-222X</issn><issn>1476-5454</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kT1PwzAQhi0EglL4AwyoiIUlcD7bcTwhVPElgVhAYrOcxGmDUqfYCRL_HpeW8jEwWDe8z72-u5eQAwqnFFh2FjjljCWAGB9FnsAGGVAu00RwwTfJAJSABBGfd8huCC8AUZSwTXaYkKhQ0gE5ujdNPXHGdaPGhrp1YdRWo25qR4XxvSsau0e2KtMEu7-qQ_J0dfk4vknuHq5vxxd3ScGl6BIjpMBSVkpJLizPMVUVZSCqrBBS5mVeIgWapyY1yKgSLCvBZlQwa5SqBGNDcr70nff5zJaFdZ03jZ77emb8u25NrX8rrp7qSfumKYAAmi4cTlYOvn3tbej0rA6FbRrjbNsHjalUaZwP04ge_0Ff2t67uJ9GqWgGGLlI4ZIqfBuCt9V6Ggp6EYFeRqBjBPozAg2x6fDnHuuWr5tHgC2BECU3sf77739sPwCqS49g</recordid><startdate>20230401</startdate><enddate>20230401</enddate><creator>Gounder, Pav</creator><creator>Selva, Dinesh</creator><creator>Rajak, Saul N.</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-2184-9535</orcidid></search><sort><creationdate>20230401</creationdate><title>Malignant lesions of the caruncle</title><author>Gounder, Pav ; Selva, Dinesh ; Rajak, Saul N.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c475t-a5752d7f99745e4b269f1305f8c577bdbd2101b6a6a2319538d0e8153ea99f533</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>692/1807/1482</topic><topic>692/699</topic><topic>Adenocarcinoma, Sebaceous - pathology</topic><topic>Basal cell carcinoma</topic><topic>Biopsy</topic><topic>Carcinoma, Basal Cell - pathology</topic><topic>Cell growth</topic><topic>Chemotherapy</topic><topic>Humans</topic><topic>Hyperplasia</topic><topic>Immunoproliferative diseases</topic><topic>Laboratory Medicine</topic><topic>Lymph nodes</topic><topic>Lymphatic system</topic><topic>Lymphocytes</topic><topic>Lymphoma</topic><topic>Malignancy</topic><topic>Medical diagnosis</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Melanoma</topic><topic>Melanoma - diagnosis</topic><topic>Melanoma - pathology</topic><topic>Melanoma - surgery</topic><topic>Metastases</topic><topic>Morbidity</topic><topic>Mortality</topic><topic>Ophthalmology</topic><topic>Pharmaceutical Sciences/Technology</topic><topic>Pigmentation</topic><topic>Radiation therapy</topic><topic>Review</topic><topic>Review Article</topic><topic>Sebaceous Gland Neoplasms - surgery</topic><topic>Skin cancer</topic><topic>Skin Neoplasms - diagnosis</topic><topic>Skin Neoplasms - pathology</topic><topic>Skin Neoplasms - surgery</topic><topic>Squamous cell carcinoma</topic><topic>Surgery</topic><topic>Surgical Oncology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gounder, Pav</creatorcontrib><creatorcontrib>Selva, Dinesh</creatorcontrib><creatorcontrib>Rajak, Saul N.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Eye (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gounder, Pav</au><au>Selva, Dinesh</au><au>Rajak, Saul N.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Malignant lesions of the caruncle</atitle><jtitle>Eye (London)</jtitle><stitle>Eye</stitle><addtitle>Eye (Lond)</addtitle><date>2023-04-01</date><risdate>2023</risdate><volume>37</volume><issue>5</issue><spage>849</spage><epage>857</epage><pages>849-857</pages><issn>0950-222X</issn><eissn>1476-5454</eissn><abstract>Caruncle malignancy is rare, but signs of disease can be easily missed by both patients and clinicians. There is significant potential for significant morbidity and even mortality from delayed diagnosis and treatment. Clinical features of primary malignant cancer include rapid growth, pigment deposition, ulcerated surface and bleeding. Malignant diagnoses include lymphoproliferative disease, basal cell carcinoma, squamous cell carcinoma, sebaceous carcinoma and malignant melanoma. Increased pigmentation is associated with melanoma, yellow coloured deposition with sebaceous carcinoma and a salmon-pink hue with lymphoproliferative disease. Treatment involves excision with margin control which may necessitate exenteration. Metastases to cervical and preauricular lymph nodes has been reported.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>35729271</pmid><doi>10.1038/s41433-022-02124-0</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-2184-9535</orcidid><oa>free_for_read</oa></addata></record> |
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subjects | 692/1807/1482 692/699 Adenocarcinoma, Sebaceous - pathology Basal cell carcinoma Biopsy Carcinoma, Basal Cell - pathology Cell growth Chemotherapy Humans Hyperplasia Immunoproliferative diseases Laboratory Medicine Lymph nodes Lymphatic system Lymphocytes Lymphoma Malignancy Medical diagnosis Medicine Medicine & Public Health Melanoma Melanoma - diagnosis Melanoma - pathology Melanoma - surgery Metastases Morbidity Mortality Ophthalmology Pharmaceutical Sciences/Technology Pigmentation Radiation therapy Review Review Article Sebaceous Gland Neoplasms - surgery Skin cancer Skin Neoplasms - diagnosis Skin Neoplasms - pathology Skin Neoplasms - surgery Squamous cell carcinoma Surgery Surgical Oncology |
title | Malignant lesions of the caruncle |
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