Protection from interleukin 1 induced destruction of articular cartilage by transforming growth factor beta: studies in anatomically intact cartilage in vitro and in vivo

The modulation of interleukin 1 (IL-1) effects on proteoglycan metabolism in intact murine patellar cartilage by transforming growth factor beta (TGF-beta) was investigated in vitro and in vivo. In vitro TGF-beta (400 pmol/l) had no effect on basal proteoglycan degradation. Proteoglycan degradation...

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Veröffentlicht in:	Annals of the rheumatic diseases 1993-03, Vol.52 (3), p.185-191
Hauptverfasser:	van Beuningen, H M, van der Kraan, P M, Arntz, O J, van den Berg, W B
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cartilage, Articular - drug effects Cartilage, Articular - metabolism Cell physiology Depression, Chemical Drug Synergism Fundamental and applied biological sciences. Psychology In Vitro Techniques Injections, Intra-Articular Interleukin-1 - antagonists & inhibitors Mice Mice, Inbred C57BL Molecular and cellular biology Proteoglycans - biosynthesis Proteoglycans - metabolism Responses to growth factors, tumor promotors, other factors Transforming Growth Factor beta - administration & dosage Transforming Growth Factor beta - pharmacology
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