Could Vaspin Be a Potential Diagnostic Marker in Endometrial Cancer?
Obesity and being overweight are risk factors for many types of cancer, including endometrial cancer. Adipose tissue is thought to be an endocrine organ that produces various hormones, including one known as vaspin. Insulin resistance, metabolic syndrome and type 2 diabetes are all associated with h...
Gespeichert in:
| Veröffentlicht in: | International journal of environmental research and public health 2023-03, Vol.20 (6), p.4999 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 6 |
| container_start_page | 4999 |
| container_title | International journal of environmental research and public health |
| container_volume | 20 |
| creator | Pietrzyk, Dominika Tkacz, Piotr Kozłowski, Mateusz Kwiatkowski, Sebastian Rychlicka, Małgorzata Pius-Sadowska, Ewa Machaliński, Bogusław Cymbaluk-Płoska, Aneta |
| description | Obesity and being overweight are risk factors for many types of cancer, including endometrial cancer. Adipose tissue is thought to be an endocrine organ that produces various hormones, including one known as vaspin. Insulin resistance, metabolic syndrome and type 2 diabetes are all associated with higher vaspin levels. A total of 127 patients divided into study (endometrial cancer) and control groups (non-cancerous) participated in this research. Serum vaspin levels were measured for all patients. The analysis was performed while taking into account grading and staging. In order to assess the usefulness of the tested protein as a new diagnostic marker, we used the plotting of a curve (ROC) and the calculation of the AUC curve to characterize the sensitivity and specificity of the parameters tested. We concluded that there were significantly lower vaspin levels in patients with endometrial cancer compared to patients with benign endometrial lesions. Vaspin may be a useful diagnostic marker in separating benign lesions from endometrial cancer. |
| doi_str_mv | 10.3390/ijerph20064999 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10049014</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A751911851</galeid><sourcerecordid>A751911851</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3569-eee63cd06a2a33c7871ba7403c2baf442b8212dba2f12df4a0f0db3553ee6f983</originalsourceid><addsrcrecordid>eNptkc1v1DAQxS0EoqVw5YgiceGyZfyZ-FSVbSlIRXAArtbEsbdeEnuxEyT-e7xqKS2qfBjL_r3nGT9CXlI45lzD27B1eXfFAJTQWj8ih1QpWAkF9PGd_QF5VsoWgHdC6afkgCvdUQ3qkJyt0zIOzXcsuxCbd67B5kuaXZwDjs1ZwE1MZQ62-YT5h8tNZc7jkCY35z2wxmhdPnlOnngci3txU4_It_fnX9cfVpefLz6uTy9XlkulV845xe0AChlybtuupT22ArhlPXohWN8xyoYema_FCwQPQ8-l5FXodcePyMm1727pJzfY2mbG0exymDD_NgmDuX8Tw5XZpF-GAggNVFSHNzcOOf1cXJnNFIp144jRpaUY1momoXbGK_r6P3SblhzrfHuKKik1l_-oDY7OhOhTfdjuTc1pK6mmtJO0UscPUHUNbgo2RedDPX9IYHMqJTt_OyQFsw_e3A--Cl7d_Zpb_G_S_A-eX6gk</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2791655935</pqid></control><display><type>article</type><title>Could Vaspin Be a Potential Diagnostic Marker in Endometrial Cancer?</title><source>MEDLINE</source><source>PubMed Central Open Access</source><source>MDPI - Multidisciplinary Digital Publishing Institute</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><creator>Pietrzyk, Dominika ; Tkacz, Piotr ; Kozłowski, Mateusz ; Kwiatkowski, Sebastian ; Rychlicka, Małgorzata ; Pius-Sadowska, Ewa ; Machaliński, Bogusław ; Cymbaluk-Płoska, Aneta</creator><creatorcontrib>Pietrzyk, Dominika ; Tkacz, Piotr ; Kozłowski, Mateusz ; Kwiatkowski, Sebastian ; Rychlicka, Małgorzata ; Pius-Sadowska, Ewa ; Machaliński, Bogusław ; Cymbaluk-Płoska, Aneta</creatorcontrib><description>Obesity and being overweight are risk factors for many types of cancer, including endometrial cancer. Adipose tissue is thought to be an endocrine organ that produces various hormones, including one known as vaspin. Insulin resistance, metabolic syndrome and type 2 diabetes are all associated with higher vaspin levels. A total of 127 patients divided into study (endometrial cancer) and control groups (non-cancerous) participated in this research. Serum vaspin levels were measured for all patients. The analysis was performed while taking into account grading and staging. In order to assess the usefulness of the tested protein as a new diagnostic marker, we used the plotting of a curve (ROC) and the calculation of the AUC curve to characterize the sensitivity and specificity of the parameters tested. We concluded that there were significantly lower vaspin levels in patients with endometrial cancer compared to patients with benign endometrial lesions. Vaspin may be a useful diagnostic marker in separating benign lesions from endometrial cancer.</description><identifier>ISSN: 1660-4601</identifier><identifier>ISSN: 1661-7827</identifier><identifier>EISSN: 1660-4601</identifier><identifier>DOI: 10.3390/ijerph20064999</identifier><identifier>PMID: 36981906</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Adipose tissue ; Adipose tissues ; Analysis ; Androgens ; Body fat ; Body mass index ; Body weight ; Cancer ; Diabetes ; Diabetes mellitus ; Diabetes mellitus (non-insulin dependent) ; Diabetes Mellitus, Type 2 ; Diagnosis ; Diagnostic systems ; Endometrial cancer ; Endometrial Neoplasms - diagnosis ; Endometrium ; Estrogens ; Female ; Gynecology ; Hormone replacement therapy ; Hormones ; Humans ; Hyperplasia ; Insulin ; Insulin Resistance ; Laboratories ; Lesions ; Metabolic disorders ; Metabolic syndrome ; Metabolism ; Normal distribution ; Obesity ; Obesity - metabolism ; Oncology, Experimental ; Ovaries ; Parameter sensitivity ; Patients ; Polyps ; Risk factors ; Serpins - metabolism ; Type 2 diabetes ; Variables ; Womens health</subject><ispartof>International journal of environmental research and public health, 2023-03, Vol.20 (6), p.4999</ispartof><rights>COPYRIGHT 2023 MDPI AG</rights><rights>2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2023 by the authors. 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3569-eee63cd06a2a33c7871ba7403c2baf442b8212dba2f12df4a0f0db3553ee6f983</cites><orcidid>0000-0002-1176-2153 ; 0000-0003-3106-8705 ; 0000-0002-9782-7578 ; 0000-0003-1504-3639 ; 0000-0002-8114-3622</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10049014/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10049014/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,882,27905,27906,53772,53774</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36981906$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pietrzyk, Dominika</creatorcontrib><creatorcontrib>Tkacz, Piotr</creatorcontrib><creatorcontrib>Kozłowski, Mateusz</creatorcontrib><creatorcontrib>Kwiatkowski, Sebastian</creatorcontrib><creatorcontrib>Rychlicka, Małgorzata</creatorcontrib><creatorcontrib>Pius-Sadowska, Ewa</creatorcontrib><creatorcontrib>Machaliński, Bogusław</creatorcontrib><creatorcontrib>Cymbaluk-Płoska, Aneta</creatorcontrib><title>Could Vaspin Be a Potential Diagnostic Marker in Endometrial Cancer?</title><title>International journal of environmental research and public health</title><addtitle>Int J Environ Res Public Health</addtitle><description>Obesity and being overweight are risk factors for many types of cancer, including endometrial cancer. Adipose tissue is thought to be an endocrine organ that produces various hormones, including one known as vaspin. Insulin resistance, metabolic syndrome and type 2 diabetes are all associated with higher vaspin levels. A total of 127 patients divided into study (endometrial cancer) and control groups (non-cancerous) participated in this research. Serum vaspin levels were measured for all patients. The analysis was performed while taking into account grading and staging. In order to assess the usefulness of the tested protein as a new diagnostic marker, we used the plotting of a curve (ROC) and the calculation of the AUC curve to characterize the sensitivity and specificity of the parameters tested. We concluded that there were significantly lower vaspin levels in patients with endometrial cancer compared to patients with benign endometrial lesions. Vaspin may be a useful diagnostic marker in separating benign lesions from endometrial cancer.</description><subject>Adipose tissue</subject><subject>Adipose tissues</subject><subject>Analysis</subject><subject>Androgens</subject><subject>Body fat</subject><subject>Body mass index</subject><subject>Body weight</subject><subject>Cancer</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Diabetes mellitus (non-insulin dependent)</subject><subject>Diabetes Mellitus, Type 2</subject><subject>Diagnosis</subject><subject>Diagnostic systems</subject><subject>Endometrial cancer</subject><subject>Endometrial Neoplasms - diagnosis</subject><subject>Endometrium</subject><subject>Estrogens</subject><subject>Female</subject><subject>Gynecology</subject><subject>Hormone replacement therapy</subject><subject>Hormones</subject><subject>Humans</subject><subject>Hyperplasia</subject><subject>Insulin</subject><subject>Insulin Resistance</subject><subject>Laboratories</subject><subject>Lesions</subject><subject>Metabolic disorders</subject><subject>Metabolic syndrome</subject><subject>Metabolism</subject><subject>Normal distribution</subject><subject>Obesity</subject><subject>Obesity - metabolism</subject><subject>Oncology, Experimental</subject><subject>Ovaries</subject><subject>Parameter sensitivity</subject><subject>Patients</subject><subject>Polyps</subject><subject>Risk factors</subject><subject>Serpins - metabolism</subject><subject>Type 2 diabetes</subject><subject>Variables</subject><subject>Womens health</subject><issn>1660-4601</issn><issn>1661-7827</issn><issn>1660-4601</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNptkc1v1DAQxS0EoqVw5YgiceGyZfyZ-FSVbSlIRXAArtbEsbdeEnuxEyT-e7xqKS2qfBjL_r3nGT9CXlI45lzD27B1eXfFAJTQWj8ih1QpWAkF9PGd_QF5VsoWgHdC6afkgCvdUQ3qkJyt0zIOzXcsuxCbd67B5kuaXZwDjs1ZwE1MZQ62-YT5h8tNZc7jkCY35z2wxmhdPnlOnngci3txU4_It_fnX9cfVpefLz6uTy9XlkulV845xe0AChlybtuupT22ArhlPXohWN8xyoYema_FCwQPQ8-l5FXodcePyMm1727pJzfY2mbG0exymDD_NgmDuX8Tw5XZpF-GAggNVFSHNzcOOf1cXJnNFIp144jRpaUY1momoXbGK_r6P3SblhzrfHuKKik1l_-oDY7OhOhTfdjuTc1pK6mmtJO0UscPUHUNbgo2RedDPX9IYHMqJTt_OyQFsw_e3A--Cl7d_Zpb_G_S_A-eX6gk</recordid><startdate>20230312</startdate><enddate>20230312</enddate><creator>Pietrzyk, Dominika</creator><creator>Tkacz, Piotr</creator><creator>Kozłowski, Mateusz</creator><creator>Kwiatkowski, Sebastian</creator><creator>Rychlicka, Małgorzata</creator><creator>Pius-Sadowska, Ewa</creator><creator>Machaliński, Bogusław</creator><creator>Cymbaluk-Płoska, Aneta</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-1176-2153</orcidid><orcidid>https://orcid.org/0000-0003-3106-8705</orcidid><orcidid>https://orcid.org/0000-0002-9782-7578</orcidid><orcidid>https://orcid.org/0000-0003-1504-3639</orcidid><orcidid>https://orcid.org/0000-0002-8114-3622</orcidid></search><sort><creationdate>20230312</creationdate><title>Could Vaspin Be a Potential Diagnostic Marker in Endometrial Cancer?</title><author>Pietrzyk, Dominika ; Tkacz, Piotr ; Kozłowski, Mateusz ; Kwiatkowski, Sebastian ; Rychlicka, Małgorzata ; Pius-Sadowska, Ewa ; Machaliński, Bogusław ; Cymbaluk-Płoska, Aneta</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3569-eee63cd06a2a33c7871ba7403c2baf442b8212dba2f12df4a0f0db3553ee6f983</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Adipose tissue</topic><topic>Adipose tissues</topic><topic>Analysis</topic><topic>Androgens</topic><topic>Body fat</topic><topic>Body mass index</topic><topic>Body weight</topic><topic>Cancer</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>Diabetes mellitus (non-insulin dependent)</topic><topic>Diabetes Mellitus, Type 2</topic><topic>Diagnosis</topic><topic>Diagnostic systems</topic><topic>Endometrial cancer</topic><topic>Endometrial Neoplasms - diagnosis</topic><topic>Endometrium</topic><topic>Estrogens</topic><topic>Female</topic><topic>Gynecology</topic><topic>Hormone replacement therapy</topic><topic>Hormones</topic><topic>Humans</topic><topic>Hyperplasia</topic><topic>Insulin</topic><topic>Insulin Resistance</topic><topic>Laboratories</topic><topic>Lesions</topic><topic>Metabolic disorders</topic><topic>Metabolic syndrome</topic><topic>Metabolism</topic><topic>Normal distribution</topic><topic>Obesity</topic><topic>Obesity - metabolism</topic><topic>Oncology, Experimental</topic><topic>Ovaries</topic><topic>Parameter sensitivity</topic><topic>Patients</topic><topic>Polyps</topic><topic>Risk factors</topic><topic>Serpins - metabolism</topic><topic>Type 2 diabetes</topic><topic>Variables</topic><topic>Womens health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pietrzyk, Dominika</creatorcontrib><creatorcontrib>Tkacz, Piotr</creatorcontrib><creatorcontrib>Kozłowski, Mateusz</creatorcontrib><creatorcontrib>Kwiatkowski, Sebastian</creatorcontrib><creatorcontrib>Rychlicka, Małgorzata</creatorcontrib><creatorcontrib>Pius-Sadowska, Ewa</creatorcontrib><creatorcontrib>Machaliński, Bogusław</creatorcontrib><creatorcontrib>Cymbaluk-Płoska, Aneta</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International journal of environmental research and public health</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pietrzyk, Dominika</au><au>Tkacz, Piotr</au><au>Kozłowski, Mateusz</au><au>Kwiatkowski, Sebastian</au><au>Rychlicka, Małgorzata</au><au>Pius-Sadowska, Ewa</au><au>Machaliński, Bogusław</au><au>Cymbaluk-Płoska, Aneta</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Could Vaspin Be a Potential Diagnostic Marker in Endometrial Cancer?</atitle><jtitle>International journal of environmental research and public health</jtitle><addtitle>Int J Environ Res Public Health</addtitle><date>2023-03-12</date><risdate>2023</risdate><volume>20</volume><issue>6</issue><spage>4999</spage><pages>4999-</pages><issn>1660-4601</issn><issn>1661-7827</issn><eissn>1660-4601</eissn><abstract>Obesity and being overweight are risk factors for many types of cancer, including endometrial cancer. Adipose tissue is thought to be an endocrine organ that produces various hormones, including one known as vaspin. Insulin resistance, metabolic syndrome and type 2 diabetes are all associated with higher vaspin levels. A total of 127 patients divided into study (endometrial cancer) and control groups (non-cancerous) participated in this research. Serum vaspin levels were measured for all patients. The analysis was performed while taking into account grading and staging. In order to assess the usefulness of the tested protein as a new diagnostic marker, we used the plotting of a curve (ROC) and the calculation of the AUC curve to characterize the sensitivity and specificity of the parameters tested. We concluded that there were significantly lower vaspin levels in patients with endometrial cancer compared to patients with benign endometrial lesions. Vaspin may be a useful diagnostic marker in separating benign lesions from endometrial cancer.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>36981906</pmid><doi>10.3390/ijerph20064999</doi><orcidid>https://orcid.org/0000-0002-1176-2153</orcidid><orcidid>https://orcid.org/0000-0003-3106-8705</orcidid><orcidid>https://orcid.org/0000-0002-9782-7578</orcidid><orcidid>https://orcid.org/0000-0003-1504-3639</orcidid><orcidid>https://orcid.org/0000-0002-8114-3622</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1660-4601 |
| ispartof | International journal of environmental research and public health, 2023-03, Vol.20 (6), p.4999 |
| issn | 1660-4601 1661-7827 1660-4601 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10049014 |
| source | MEDLINE; PubMed Central Open Access; MDPI - Multidisciplinary Digital Publishing Institute; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Adipose tissue Adipose tissues Analysis Androgens Body fat Body mass index Body weight Cancer Diabetes Diabetes mellitus Diabetes mellitus (non-insulin dependent) Diabetes Mellitus, Type 2 Diagnosis Diagnostic systems Endometrial cancer Endometrial Neoplasms - diagnosis Endometrium Estrogens Female Gynecology Hormone replacement therapy Hormones Humans Hyperplasia Insulin Insulin Resistance Laboratories Lesions Metabolic disorders Metabolic syndrome Metabolism Normal distribution Obesity Obesity - metabolism Oncology, Experimental Ovaries Parameter sensitivity Patients Polyps Risk factors Serpins - metabolism Type 2 diabetes Variables Womens health |
| title | Could Vaspin Be a Potential Diagnostic Marker in Endometrial Cancer? |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-17T20%3A55%3A17IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Could%20Vaspin%20Be%20a%20Potential%20Diagnostic%20Marker%20in%20Endometrial%20Cancer?&rft.jtitle=International%20journal%20of%20environmental%20research%20and%20public%20health&rft.au=Pietrzyk,%20Dominika&rft.date=2023-03-12&rft.volume=20&rft.issue=6&rft.spage=4999&rft.pages=4999-&rft.issn=1660-4601&rft.eissn=1660-4601&rft_id=info:doi/10.3390/ijerph20064999&rft_dat=%3Cgale_pubme%3EA751911851%3C/gale_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2791655935&rft_id=info:pmid/36981906&rft_galeid=A751911851&rfr_iscdi=true |