MicroRNA as a Diagnostic Tool, Therapeutic Target and Potential Biomarker in Cutaneous Malignant Melanoma Detection-Narrative Review
Melanoma is the most serious type of skin cancer, causing a large majority of deaths but accounting for only ~1% of all skin cancer cases. The worldwide incidence of malignant melanoma is increasing, causing a serious socio-economic problem. Melanoma is diagnosed mainly in young and middle-aged peop...
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| Veröffentlicht in: | International journal of molecular sciences 2023-03, Vol.24 (6), p.5386 |
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| container_title | International journal of molecular sciences |
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| creator | Poniewierska-Baran, Agata Zadroga, Łukasz Danilyan, Edo Małkowska, Paulina Niedźwiedzka-Rystwej, Paulina Pawlik, Andrzej |
| description | Melanoma is the most serious type of skin cancer, causing a large majority of deaths but accounting for only ~1% of all skin cancer cases. The worldwide incidence of malignant melanoma is increasing, causing a serious socio-economic problem. Melanoma is diagnosed mainly in young and middle-aged people, which distinguishes it from other solid tumors detected mainly in mature people. The early detection of cutaneous malignant melanoma (CMM) remains a priority and it is a key factor limiting mortality. Doctors and scientists around the world want to improve the quality of diagnosis and treatment, and are constantly looking for new, promising opportunities, including the use of microRNAs (miRNAs), to fight melanoma cancer. This article reviews miRNA as a potential biomarker and diagnostics tool as a therapeutic drugs in CMM treatment. We also present a review of the current clinical trials being carried out worldwide, in which miRNAs are a target for melanoma treatment. |
| doi_str_mv | 10.3390/ijms24065386 |
| format | Article |
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The worldwide incidence of malignant melanoma is increasing, causing a serious socio-economic problem. Melanoma is diagnosed mainly in young and middle-aged people, which distinguishes it from other solid tumors detected mainly in mature people. The early detection of cutaneous malignant melanoma (CMM) remains a priority and it is a key factor limiting mortality. Doctors and scientists around the world want to improve the quality of diagnosis and treatment, and are constantly looking for new, promising opportunities, including the use of microRNAs (miRNAs), to fight melanoma cancer. This article reviews miRNA as a potential biomarker and diagnostics tool as a therapeutic drugs in CMM treatment. We also present a review of the current clinical trials being carried out worldwide, in which miRNAs are a target for melanoma treatment.</description><identifier>ISSN: 1422-0067</identifier><identifier>ISSN: 1661-6596</identifier><identifier>EISSN: 1422-0067</identifier><identifier>DOI: 10.3390/ijms24065386</identifier><identifier>PMID: 36982460</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Biomarkers ; Care and treatment ; Clinical trials ; Development and progression ; Drug development ; Health aspects ; Humans ; Kinases ; Melanoma ; Melanoma - diagnosis ; Melanoma - genetics ; Melanoma - therapy ; Melanoma, Cutaneous Malignant ; MicroRNA ; MicroRNAs ; MicroRNAs - genetics ; Middle Aged ; miRNA ; Review ; Skin ; Skin cancer ; Skin Neoplasms - diagnosis ; Skin Neoplasms - genetics ; Skin Neoplasms - therapy ; Solid tumors ; Therapeutic targets</subject><ispartof>International journal of molecular sciences, 2023-03, Vol.24 (6), p.5386</ispartof><rights>COPYRIGHT 2023 MDPI AG</rights><rights>2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). 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The worldwide incidence of malignant melanoma is increasing, causing a serious socio-economic problem. Melanoma is diagnosed mainly in young and middle-aged people, which distinguishes it from other solid tumors detected mainly in mature people. The early detection of cutaneous malignant melanoma (CMM) remains a priority and it is a key factor limiting mortality. Doctors and scientists around the world want to improve the quality of diagnosis and treatment, and are constantly looking for new, promising opportunities, including the use of microRNAs (miRNAs), to fight melanoma cancer. This article reviews miRNA as a potential biomarker and diagnostics tool as a therapeutic drugs in CMM treatment. We also present a review of the current clinical trials being carried out worldwide, in which miRNAs are a target for melanoma treatment.</description><subject>Biomarkers</subject><subject>Care and treatment</subject><subject>Clinical trials</subject><subject>Development and progression</subject><subject>Drug development</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Kinases</subject><subject>Melanoma</subject><subject>Melanoma - diagnosis</subject><subject>Melanoma - genetics</subject><subject>Melanoma - therapy</subject><subject>Melanoma, Cutaneous Malignant</subject><subject>MicroRNA</subject><subject>MicroRNAs</subject><subject>MicroRNAs - genetics</subject><subject>Middle Aged</subject><subject>miRNA</subject><subject>Review</subject><subject>Skin</subject><subject>Skin cancer</subject><subject>Skin Neoplasms - diagnosis</subject><subject>Skin Neoplasms - genetics</subject><subject>Skin Neoplasms - therapy</subject><subject>Solid tumors</subject><subject>Therapeutic targets</subject><issn>1422-0067</issn><issn>1661-6596</issn><issn>1422-0067</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNptks1vEzEQxVcIREvhxhlZ4sKhKf5a7_qEQsqX1BRUhbM18c6mLhs72N4g7vzhOKRUKUI-2Br_5o2e_arqOaNnQmj62t2sE5dU1aJVD6pjJjmfUKqahwfno-pJSjeUcsFr_bg6Ekq3XCp6XP2aOxvD1eWUQCJAzh2sfEjZWbIIYTgli2uMsMHxTwXiCjMB35EvIaPPDgby1oU1xG8YifNkNmbwGMZE5jC4lQefyRwH8IUh55jRZhf85BJihOy2SK5w6_DH0-pRD0PCZ7f7SfX1_bvF7OPk4vOHT7PpxcTKluYJ9LqnWLccWtspxu0SpewYZbprqZAdaMmbXrJOtmKpGmqVRN020AhUrOFMnFRv9rqbcbnGzhYLEQazia5Y-GkCOHP_xrtrswpbwyiVrRZNUXh1qxDD9xFTNmuXLA7D3rbhjeY1lbXmBX35D3oTxuiLvx3FVC1bdkCtYEDjfB_KYLsTNdOmZporqUShzv5DldXh2tngsXelfq_hdN9QPjeliP2dSUbNLjbmMDYFf3H4MHfw35yI3x8RvZ8</recordid><startdate>20230311</startdate><enddate>20230311</enddate><creator>Poniewierska-Baran, Agata</creator><creator>Zadroga, Łukasz</creator><creator>Danilyan, Edo</creator><creator>Małkowska, Paulina</creator><creator>Niedźwiedzka-Rystwej, Paulina</creator><creator>Pawlik, Andrzej</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-4065-3842</orcidid><orcidid>https://orcid.org/0000-0001-6719-803X</orcidid><orcidid>https://orcid.org/0000-0001-7453-0520</orcidid><orcidid>https://orcid.org/0000-0001-6557-1208</orcidid><orcidid>https://orcid.org/0000-0003-2430-5020</orcidid></search><sort><creationdate>20230311</creationdate><title>MicroRNA as a Diagnostic Tool, Therapeutic Target and Potential Biomarker in Cutaneous Malignant Melanoma Detection-Narrative Review</title><author>Poniewierska-Baran, Agata ; 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The worldwide incidence of malignant melanoma is increasing, causing a serious socio-economic problem. Melanoma is diagnosed mainly in young and middle-aged people, which distinguishes it from other solid tumors detected mainly in mature people. The early detection of cutaneous malignant melanoma (CMM) remains a priority and it is a key factor limiting mortality. Doctors and scientists around the world want to improve the quality of diagnosis and treatment, and are constantly looking for new, promising opportunities, including the use of microRNAs (miRNAs), to fight melanoma cancer. This article reviews miRNA as a potential biomarker and diagnostics tool as a therapeutic drugs in CMM treatment. 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| subjects | Biomarkers Care and treatment Clinical trials Development and progression Drug development Health aspects Humans Kinases Melanoma Melanoma - diagnosis Melanoma - genetics Melanoma - therapy Melanoma, Cutaneous Malignant MicroRNA MicroRNAs MicroRNAs - genetics Middle Aged miRNA Review Skin Skin cancer Skin Neoplasms - diagnosis Skin Neoplasms - genetics Skin Neoplasms - therapy Solid tumors Therapeutic targets |
| title | MicroRNA as a Diagnostic Tool, Therapeutic Target and Potential Biomarker in Cutaneous Malignant Melanoma Detection-Narrative Review |
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