Scoping Review on Epigenetic Mechanisms in Primary Immune Thrombocytopenia
Immune Thrombocytopenia (ITP) is an autoimmune blood disorder that involves multiple pathways responsible for the homeostasis of the immune system. Numerous pieces of literature have proposed the potential of immune-related genes as diagnostic and prognostic biomarkers, which mostly implicate the ro...
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| Veröffentlicht in: | Genes 2023-02, Vol.14 (3), p.555 |
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| description | Immune Thrombocytopenia (ITP) is an autoimmune blood disorder that involves multiple pathways responsible for the homeostasis of the immune system. Numerous pieces of literature have proposed the potential of immune-related genes as diagnostic and prognostic biomarkers, which mostly implicate the role of B cells and T cells in the pathogenesis of ITP. However, a more in-depth understanding is required of how these immune-related genes are regulated. Thus, this scoping review aims to collate evidence and further elucidate each possible epigenetics mechanism in the regulation of immunological pathways pertinent to the pathogenesis of ITP. This encompasses DNA methylation, histone modification, and non-coding RNA. A total of 41 studies were scrutinized to further clarify how each of the epigenetics mechanisms is related to the pathogenesis of ITP. Identifying epigenetics mechanisms will provide a new paradigm that may assist in the diagnosis and treatment of immune thrombocytopenia. |
| doi_str_mv | 10.3390/genes14030555 |
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Numerous pieces of literature have proposed the potential of immune-related genes as diagnostic and prognostic biomarkers, which mostly implicate the role of B cells and T cells in the pathogenesis of ITP. However, a more in-depth understanding is required of how these immune-related genes are regulated. Thus, this scoping review aims to collate evidence and further elucidate each possible epigenetics mechanism in the regulation of immunological pathways pertinent to the pathogenesis of ITP. This encompasses DNA methylation, histone modification, and non-coding RNA. A total of 41 studies were scrutinized to further clarify how each of the epigenetics mechanisms is related to the pathogenesis of ITP. Identifying epigenetics mechanisms will provide a new paradigm that may assist in the diagnosis and treatment of immune thrombocytopenia.</description><identifier>ISSN: 2073-4425</identifier><identifier>EISSN: 2073-4425</identifier><identifier>DOI: 10.3390/genes14030555</identifier><identifier>PMID: 36980827</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Case reports ; Cytokines ; Cytotoxicity ; Development and progression ; DNA methylation ; DNA Methylation - genetics ; Epigenesis, Genetic ; Epigenetic inheritance ; Epigenetics ; Gene expression ; Genetic aspects ; Health aspects ; Histones ; Homeostasis ; Humans ; Idiopathic thrombocytopenic purpura ; Immune system ; Infections ; Lymphocytes ; Lymphocytes B ; Lymphocytes T ; Pathogenesis ; Polymorphism ; Purpura ; Purpura, Thrombocytopenic, Idiopathic - genetics ; Review ; RNA modification ; T-Lymphocytes - metabolism ; Thrombocytopenia ; Thrombocytopenia - genetics</subject><ispartof>Genes, 2023-02, Vol.14 (3), p.555</ispartof><rights>COPYRIGHT 2023 MDPI AG</rights><rights>2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). 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Numerous pieces of literature have proposed the potential of immune-related genes as diagnostic and prognostic biomarkers, which mostly implicate the role of B cells and T cells in the pathogenesis of ITP. However, a more in-depth understanding is required of how these immune-related genes are regulated. Thus, this scoping review aims to collate evidence and further elucidate each possible epigenetics mechanism in the regulation of immunological pathways pertinent to the pathogenesis of ITP. This encompasses DNA methylation, histone modification, and non-coding RNA. A total of 41 studies were scrutinized to further clarify how each of the epigenetics mechanisms is related to the pathogenesis of ITP. Identifying epigenetics mechanisms will provide a new paradigm that may assist in the diagnosis and treatment of immune thrombocytopenia.</description><subject>Case reports</subject><subject>Cytokines</subject><subject>Cytotoxicity</subject><subject>Development and progression</subject><subject>DNA methylation</subject><subject>DNA Methylation - genetics</subject><subject>Epigenesis, Genetic</subject><subject>Epigenetic inheritance</subject><subject>Epigenetics</subject><subject>Gene expression</subject><subject>Genetic aspects</subject><subject>Health aspects</subject><subject>Histones</subject><subject>Homeostasis</subject><subject>Humans</subject><subject>Idiopathic thrombocytopenic purpura</subject><subject>Immune system</subject><subject>Infections</subject><subject>Lymphocytes</subject><subject>Lymphocytes B</subject><subject>Lymphocytes T</subject><subject>Pathogenesis</subject><subject>Polymorphism</subject><subject>Purpura</subject><subject>Purpura, Thrombocytopenic, Idiopathic - genetics</subject><subject>Review</subject><subject>RNA modification</subject><subject>T-Lymphocytes - metabolism</subject><subject>Thrombocytopenia</subject><subject>Thrombocytopenia - genetics</subject><issn>2073-4425</issn><issn>2073-4425</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNptkstP3DAQxi1UBIhy7LWK1EsvAT8T51QhRHloKxBsz5bXGe8aJXYaJ1vtf4-j5bVV7YMt-zef5xsPQl8IPmWswmdL8BAJxwwLIfbQEcUlyzmn4tOH_SE6ifEJp8ExxVgcoENWVBJLWh6h20cTOueX2QOsHfzNgs8uOzfpDs5kv8CstHexjZnz2X3vWt1vspu2HT1k81Uf2kUwmyF04J3-jPatbiKcvKzH6PfPy_nFdT67u7q5OJ_lhks25JpasFLXVGPCLK5LLTShCyoNI8RYaWtqmawNSa4k56CxLYQwxFS1WFQg2DH6sdXtxkULtQE_9LpR3TY7FbRTuzferdQyrBVJFZBFSZPC9xeFPvwZIQ6qddFA02gPYYyKlhXlVcXlhH77B30KY--Tv4niBa8wKd6ppW5AOW9DethMouq85KwsBCVT4qf_odKsoXUmeLAune8E5NsA04cYe7BvJglWUwOonQZI_NePlXmjX7-bPQNFpKt3</recordid><startdate>20230223</startdate><enddate>20230223</enddate><creator>Tan, Jian Hong</creator><creator>Ahmad Azahari, Ahmad Hazim Syakir</creator><creator>Ali, Adli</creator><creator>Ismail, Noor Akmal Shareela</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>COVID</scope><scope>DWQXO</scope><scope>FR3</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M7P</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-2642-885X</orcidid><orcidid>https://orcid.org/0000-0001-5615-5966</orcidid></search><sort><creationdate>20230223</creationdate><title>Scoping Review on Epigenetic Mechanisms in Primary Immune Thrombocytopenia</title><author>Tan, Jian Hong ; Ahmad Azahari, Ahmad Hazim Syakir ; Ali, Adli ; Ismail, Noor Akmal Shareela</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c483t-a2fef8ad2a013f0d7a5a12b28c311cf8fd2f38dc1030844ea0f655c1c9d5b9e53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Case reports</topic><topic>Cytokines</topic><topic>Cytotoxicity</topic><topic>Development and progression</topic><topic>DNA methylation</topic><topic>DNA Methylation - genetics</topic><topic>Epigenesis, Genetic</topic><topic>Epigenetic inheritance</topic><topic>Epigenetics</topic><topic>Gene expression</topic><topic>Genetic aspects</topic><topic>Health aspects</topic><topic>Histones</topic><topic>Homeostasis</topic><topic>Humans</topic><topic>Idiopathic thrombocytopenic purpura</topic><topic>Immune system</topic><topic>Infections</topic><topic>Lymphocytes</topic><topic>Lymphocytes B</topic><topic>Lymphocytes T</topic><topic>Pathogenesis</topic><topic>Polymorphism</topic><topic>Purpura</topic><topic>Purpura, Thrombocytopenic, Idiopathic - genetics</topic><topic>Review</topic><topic>RNA modification</topic><topic>T-Lymphocytes - metabolism</topic><topic>Thrombocytopenia</topic><topic>Thrombocytopenia - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tan, Jian Hong</creatorcontrib><creatorcontrib>Ahmad Azahari, Ahmad Hazim Syakir</creatorcontrib><creatorcontrib>Ali, Adli</creatorcontrib><creatorcontrib>Ismail, Noor Akmal Shareela</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>Coronavirus Research Database</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Genes</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tan, Jian Hong</au><au>Ahmad Azahari, Ahmad Hazim Syakir</au><au>Ali, Adli</au><au>Ismail, Noor Akmal Shareela</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Scoping Review on Epigenetic Mechanisms in Primary Immune Thrombocytopenia</atitle><jtitle>Genes</jtitle><addtitle>Genes (Basel)</addtitle><date>2023-02-23</date><risdate>2023</risdate><volume>14</volume><issue>3</issue><spage>555</spage><pages>555-</pages><issn>2073-4425</issn><eissn>2073-4425</eissn><abstract>Immune Thrombocytopenia (ITP) is an autoimmune blood disorder that involves multiple pathways responsible for the homeostasis of the immune system. Numerous pieces of literature have proposed the potential of immune-related genes as diagnostic and prognostic biomarkers, which mostly implicate the role of B cells and T cells in the pathogenesis of ITP. However, a more in-depth understanding is required of how these immune-related genes are regulated. Thus, this scoping review aims to collate evidence and further elucidate each possible epigenetics mechanism in the regulation of immunological pathways pertinent to the pathogenesis of ITP. This encompasses DNA methylation, histone modification, and non-coding RNA. A total of 41 studies were scrutinized to further clarify how each of the epigenetics mechanisms is related to the pathogenesis of ITP. Identifying epigenetics mechanisms will provide a new paradigm that may assist in the diagnosis and treatment of immune thrombocytopenia.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>36980827</pmid><doi>10.3390/genes14030555</doi><orcidid>https://orcid.org/0000-0003-2642-885X</orcidid><orcidid>https://orcid.org/0000-0001-5615-5966</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Case reports Cytokines Cytotoxicity Development and progression DNA methylation DNA Methylation - genetics Epigenesis, Genetic Epigenetic inheritance Epigenetics Gene expression Genetic aspects Health aspects Histones Homeostasis Humans Idiopathic thrombocytopenic purpura Immune system Infections Lymphocytes Lymphocytes B Lymphocytes T Pathogenesis Polymorphism Purpura Purpura, Thrombocytopenic, Idiopathic - genetics Review RNA modification T-Lymphocytes - metabolism Thrombocytopenia Thrombocytopenia - genetics |
| title | Scoping Review on Epigenetic Mechanisms in Primary Immune Thrombocytopenia |
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