The Influence of Obesity on Melanoma and Sentinel Lymph Node Diagnosis: A Retrospective Monocentric Study in 1001 Patients
(1) Background: While obesity is a known independent risk factor in the development of melanoma, there is no consensus on its influence on melanoma prognosis. (2) Methods: In a monocentric retrospective study, data was collected from patients who underwent sentinel lymph node (SLN) biopsy for stage...
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| Veröffentlicht in: | Cancers 2023-03, Vol.15 (6), p.1806 |
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| creator | Almeida Oliveira, Filipa Klose, Julie Schulze, Hans-Joachim Ribeiro Teixeira, Marta Dermietzel, Alexander Wellenbrock, Sascha Herter-Sprie, Grit-Sophie Hirsch, Tobias Kueckelhaus, Maximilian |
| description | (1) Background: While obesity is a known independent risk factor in the development of melanoma, there is no consensus on its influence on melanoma prognosis. (2) Methods: In a monocentric retrospective study, data was collected from patients who underwent sentinel lymph node (SLN) biopsy for stage IB-IIC melanoma between 2013 and 2018. Patients were divided into groups according to their body mass index (BMI). The association between BMI and melanoma features, as well as the risk factors for metastases in SLN were examined. (3) Results: Of the 1001 patients, 336 had normal weight (BMI < 25), 402 were overweight (BMI >= 25 and = 30 and = 35). Overweightness and obesity were associated with higher tumor thicknesses at time of diagnosis. Ulceration was not influenced by the patient's weight. Metastases in sentinel lymph node was almost twice more likely in extremely obese patients than in normal weight patients. Independent risk factors for metastases in SLN in our study were tumor thickness, ulceration, and BMI > 35. (4) Conclusions: This is the first study to show higher metastases rates in high-BMI patients with melanoma, raising important questions regarding the screening and treatment of this specific patient population. |
| doi_str_mv | 10.3390/cancers15061806 |
| format | Article |
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(2) Methods: In a monocentric retrospective study, data was collected from patients who underwent sentinel lymph node (SLN) biopsy for stage IB-IIC melanoma between 2013 and 2018. Patients were divided into groups according to their body mass index (BMI). The association between BMI and melanoma features, as well as the risk factors for metastases in SLN were examined. (3) Results: Of the 1001 patients, 336 had normal weight (BMI < 25), 402 were overweight (BMI >= 25 and <30), 173 obese (BMI >= 30 and <35) and 90 extremely obese (BMI >= 35). Overweightness and obesity were associated with higher tumor thicknesses at time of diagnosis. Ulceration was not influenced by the patient's weight. Metastases in sentinel lymph node was almost twice more likely in extremely obese patients than in normal weight patients. Independent risk factors for metastases in SLN in our study were tumor thickness, ulceration, and BMI > 35. (4) Conclusions: This is the first study to show higher metastases rates in high-BMI patients with melanoma, raising important questions regarding the screening and treatment of this specific patient population.</description><identifier>ISSN: 2072-6694</identifier><identifier>EISSN: 2072-6694</identifier><identifier>DOI: 10.3390/cancers15061806</identifier><identifier>PMID: 36980693</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Age ; Biopsy ; Body mass index ; Body weight ; Cancer ; Complications and side effects ; Diagnosis ; Gender ; Influence ; Lymph nodes ; Lymphatic system ; Melanoma ; Metastases ; Metastasis ; Methods ; Obesity ; Overweight ; Patients ; Prognosis ; Risk factors ; Sentinel lymph node biopsy ; Tumors</subject><ispartof>Cancers, 2023-03, Vol.15 (6), p.1806</ispartof><rights>COPYRIGHT 2023 MDPI AG</rights><rights>2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2023 by the authors. 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c489t-914bda9ba5fd7f91930cf65bd08c3a5b944f0c3306e4a8c86418249b15af2ccb3</citedby><cites>FETCH-LOGICAL-c489t-914bda9ba5fd7f91930cf65bd08c3a5b944f0c3306e4a8c86418249b15af2ccb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10046741/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10046741/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36980693$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Almeida Oliveira, Filipa</creatorcontrib><creatorcontrib>Klose, Julie</creatorcontrib><creatorcontrib>Schulze, Hans-Joachim</creatorcontrib><creatorcontrib>Ribeiro Teixeira, Marta</creatorcontrib><creatorcontrib>Dermietzel, Alexander</creatorcontrib><creatorcontrib>Wellenbrock, Sascha</creatorcontrib><creatorcontrib>Herter-Sprie, Grit-Sophie</creatorcontrib><creatorcontrib>Hirsch, Tobias</creatorcontrib><creatorcontrib>Kueckelhaus, Maximilian</creatorcontrib><title>The Influence of Obesity on Melanoma and Sentinel Lymph Node Diagnosis: A Retrospective Monocentric Study in 1001 Patients</title><title>Cancers</title><addtitle>Cancers (Basel)</addtitle><description>(1) Background: While obesity is a known independent risk factor in the development of melanoma, there is no consensus on its influence on melanoma prognosis. (2) Methods: In a monocentric retrospective study, data was collected from patients who underwent sentinel lymph node (SLN) biopsy for stage IB-IIC melanoma between 2013 and 2018. Patients were divided into groups according to their body mass index (BMI). The association between BMI and melanoma features, as well as the risk factors for metastases in SLN were examined. (3) Results: Of the 1001 patients, 336 had normal weight (BMI < 25), 402 were overweight (BMI >= 25 and <30), 173 obese (BMI >= 30 and <35) and 90 extremely obese (BMI >= 35). Overweightness and obesity were associated with higher tumor thicknesses at time of diagnosis. Ulceration was not influenced by the patient's weight. Metastases in sentinel lymph node was almost twice more likely in extremely obese patients than in normal weight patients. Independent risk factors for metastases in SLN in our study were tumor thickness, ulceration, and BMI > 35. (4) Conclusions: This is the first study to show higher metastases rates in high-BMI patients with melanoma, raising important questions regarding the screening and treatment of this specific patient population.</description><subject>Age</subject><subject>Biopsy</subject><subject>Body mass index</subject><subject>Body weight</subject><subject>Cancer</subject><subject>Complications and side effects</subject><subject>Diagnosis</subject><subject>Gender</subject><subject>Influence</subject><subject>Lymph nodes</subject><subject>Lymphatic system</subject><subject>Melanoma</subject><subject>Metastases</subject><subject>Metastasis</subject><subject>Methods</subject><subject>Obesity</subject><subject>Overweight</subject><subject>Patients</subject><subject>Prognosis</subject><subject>Risk factors</subject><subject>Sentinel lymph node biopsy</subject><subject>Tumors</subject><issn>2072-6694</issn><issn>2072-6694</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNptkk1v3CAQhlHVqInSnHOrkHrpZRMwGJteqlX6FWnTVE1yRhgPu0Q2bIwdafvrO9uk-VLhAILnfZkZhpBDzo6E0OzY2ehgyLxkitdMvSJ7BauKmVJavn6y3yUHOV8zHELwSlVvyK5QGgVa7JHflyugp9F3E6AZTZ6eN5DDuKEp0jPobEy9pTa29ALiGCJ0dLHp1yv6I7VAPwe7jCmH_JHO6S8Yh5TX4MZwC_QsxeRQMgRHL8ap3dAQKWeM0592DHiR35Idb7sMB_frPrn6-uXy5Ptscf7t9GS-mDlZ63GmuWxaqxtb-rbymmvBnFdl07LaCVs2WkrPnBBMgbS1q5XkdSF1w0vrC-casU8-3fmup6aH9m9QtjPrIfR22Jhkg3l-E8PKLNOtwWilqiRHhw_3DkO6mSCPpg_ZQYfVgTRlU1S6KDE1XSP6_gV6naYhYn5bipdaF7V-pJa2AxOiT_iw25qaeSVFpbgsFVJH_6FwttAHlyL4gOfPBMd3AocfkQfwD0lyZrYtY160DCrePa3NA_-vQcQf6yy82w</recordid><startdate>20230316</startdate><enddate>20230316</enddate><creator>Almeida Oliveira, Filipa</creator><creator>Klose, Julie</creator><creator>Schulze, Hans-Joachim</creator><creator>Ribeiro Teixeira, Marta</creator><creator>Dermietzel, Alexander</creator><creator>Wellenbrock, Sascha</creator><creator>Herter-Sprie, Grit-Sophie</creator><creator>Hirsch, Tobias</creator><creator>Kueckelhaus, Maximilian</creator><general>MDPI AG</general><general>MDPI</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7TO</scope><scope>7XB</scope><scope>8FE</scope><scope>8FH</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20230316</creationdate><title>The Influence of Obesity on Melanoma and Sentinel Lymph Node Diagnosis: A Retrospective Monocentric Study in 1001 Patients</title><author>Almeida Oliveira, Filipa ; Klose, Julie ; Schulze, Hans-Joachim ; Ribeiro Teixeira, Marta ; Dermietzel, Alexander ; Wellenbrock, Sascha ; Herter-Sprie, Grit-Sophie ; Hirsch, Tobias ; Kueckelhaus, Maximilian</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c489t-914bda9ba5fd7f91930cf65bd08c3a5b944f0c3306e4a8c86418249b15af2ccb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Age</topic><topic>Biopsy</topic><topic>Body mass index</topic><topic>Body weight</topic><topic>Cancer</topic><topic>Complications and side effects</topic><topic>Diagnosis</topic><topic>Gender</topic><topic>Influence</topic><topic>Lymph nodes</topic><topic>Lymphatic system</topic><topic>Melanoma</topic><topic>Metastases</topic><topic>Metastasis</topic><topic>Methods</topic><topic>Obesity</topic><topic>Overweight</topic><topic>Patients</topic><topic>Prognosis</topic><topic>Risk factors</topic><topic>Sentinel lymph node biopsy</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Almeida Oliveira, Filipa</creatorcontrib><creatorcontrib>Klose, Julie</creatorcontrib><creatorcontrib>Schulze, Hans-Joachim</creatorcontrib><creatorcontrib>Ribeiro Teixeira, Marta</creatorcontrib><creatorcontrib>Dermietzel, Alexander</creatorcontrib><creatorcontrib>Wellenbrock, Sascha</creatorcontrib><creatorcontrib>Herter-Sprie, Grit-Sophie</creatorcontrib><creatorcontrib>Hirsch, Tobias</creatorcontrib><creatorcontrib>Kueckelhaus, Maximilian</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Research Library</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cancers</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Almeida Oliveira, Filipa</au><au>Klose, Julie</au><au>Schulze, Hans-Joachim</au><au>Ribeiro Teixeira, Marta</au><au>Dermietzel, Alexander</au><au>Wellenbrock, Sascha</au><au>Herter-Sprie, Grit-Sophie</au><au>Hirsch, Tobias</au><au>Kueckelhaus, Maximilian</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Influence of Obesity on Melanoma and Sentinel Lymph Node Diagnosis: A Retrospective Monocentric Study in 1001 Patients</atitle><jtitle>Cancers</jtitle><addtitle>Cancers (Basel)</addtitle><date>2023-03-16</date><risdate>2023</risdate><volume>15</volume><issue>6</issue><spage>1806</spage><pages>1806-</pages><issn>2072-6694</issn><eissn>2072-6694</eissn><abstract>(1) Background: While obesity is a known independent risk factor in the development of melanoma, there is no consensus on its influence on melanoma prognosis. (2) Methods: In a monocentric retrospective study, data was collected from patients who underwent sentinel lymph node (SLN) biopsy for stage IB-IIC melanoma between 2013 and 2018. Patients were divided into groups according to their body mass index (BMI). The association between BMI and melanoma features, as well as the risk factors for metastases in SLN were examined. (3) Results: Of the 1001 patients, 336 had normal weight (BMI < 25), 402 were overweight (BMI >= 25 and <30), 173 obese (BMI >= 30 and <35) and 90 extremely obese (BMI >= 35). Overweightness and obesity were associated with higher tumor thicknesses at time of diagnosis. Ulceration was not influenced by the patient's weight. Metastases in sentinel lymph node was almost twice more likely in extremely obese patients than in normal weight patients. Independent risk factors for metastases in SLN in our study were tumor thickness, ulceration, and BMI > 35. (4) Conclusions: This is the first study to show higher metastases rates in high-BMI patients with melanoma, raising important questions regarding the screening and treatment of this specific patient population.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>36980693</pmid><doi>10.3390/cancers15061806</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Age Biopsy Body mass index Body weight Cancer Complications and side effects Diagnosis Gender Influence Lymph nodes Lymphatic system Melanoma Metastases Metastasis Methods Obesity Overweight Patients Prognosis Risk factors Sentinel lymph node biopsy Tumors |
| title | The Influence of Obesity on Melanoma and Sentinel Lymph Node Diagnosis: A Retrospective Monocentric Study in 1001 Patients |
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