Pyruvate Dehydrogenase Kinase 4 Deficiency Increases Tumorigenesis in a Murine Model of Bladder Cancer

Pyruvate dehydrogenase kinase 4 (PDK4) is a mitochondrial isozyme in the PDK family (PDK1-4) partially responsible for phosphorylation of pyruvate dehydrogenase (PDH). Phosphorylation of PDH is thought to result in a pro-proliferative shift in metabolism that sustains growth of cancer cells. Previou...

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Veröffentlicht in:	Cancers 2023-03, Vol.15 (6), p.1654
Hauptverfasser:	Woolbright, Benjamin L, Rajendran, Ganeshkumar, Abbott, Erika, Martin, Austin, Didde, Ryan, Dennis, Katie, Harris, Robert A, Taylor, 3rd, John A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Bladder cancer Cancer Cancer therapies Carcinogenesis Causes of Cell proliferation Cisplatin Dehydrogenases Development and progression Dichloroacetic acid Drinking water Health aspects Immunotherapy Kinases Liver cancer Metabolism Mitochondria Phosphorylation Phosphotransferases Pyruvic acid Tumor cell lines Tumor suppressor genes Tumorigenesis Tumors
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