Molecular mechanisms targeting drug-resistance and metastasis in colorectal cancer: Updates and beyond

Colorectal cancer (CRC) is the third most diagnosed malignancy and a major leading cause of cancer-related deaths worldwide. Despite advances in therapeutic regimens, the number of patients presenting with metastatic CRC (mCRC) is increasing due to resistance to therapy, conferred by a small populat...

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Veröffentlicht in:	World journal of gastroenterology : WJG 2023-03, Vol.29 (9), p.1395-1426
Hauptverfasser:	Al Bitar, Samar, El-Sabban, Marwan, Doughan, Samer, Abou-Kheir, Wassim
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - therapeutic use Colorectal Neoplasms - drug therapy Colorectal Neoplasms - genetics Colorectal Neoplasms - metabolism Humans Molecular Targeted Therapy Neoplasm Metastasis - drug therapy Prognosis Receptor, ErbB-2 Review Vascular Endothelial Growth Factor A
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