Process and System Clearances in Pharmacokinetic Models: Our Basic Clearance Concepts Are Correct

Clearances are important parameters in pharmacokinetic (PK) models. All clearances in PK models are either process clearances that include diffusion, transport, and metabolism clearances or system clearances that include organ and systemic clearance. Clearance and volume of distribution are two inde...

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Veröffentlicht in:	Drug metabolism and disposition 2023-04, Vol.51 (4), p.532-542
Hauptverfasser:	Korzekwa, Ken, Nagar, Swati
Format:	Artikel
Sprache:	eng
Schlagworte:	Kinetics Minireview Models, Biological Plasma
Online-Zugang:	Volltext
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