Fasting C‐peptide values among adolescents in the National Health and Nutrition Examination Surveys
Aim To report fasting C‐peptide values and variations across demographics in healthy non‐diabetic adolescents included in the National Health and Nutrition Examination Surveys (NHANES) dataset. Research Design and Methods In this analysis, we used fasting C‐peptide data from the 1999 to 2004 NHANES...
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| Veröffentlicht in: | Diabetes, obesity & metabolism obesity & metabolism, 2022-03, Vol.24 (3), p.539-545 |
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| creator | Soni, Priya Y. Wang, Yumin Eckert, George J. Ismail, Heba M. |
| description | Aim
To report fasting C‐peptide values and variations across demographics in healthy non‐diabetic adolescents included in the National Health and Nutrition Examination Surveys (NHANES) dataset.
Research Design and Methods
In this analysis, we used fasting C‐peptide data from the 1999 to 2004 NHANES dataset for participants aged 12 to |
| doi_str_mv | 10.1111/dom.14611 |
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| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10043780</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2628407950</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4041-9f31d7b4c300347e091f38d717f3f64a2d6ce4ed7a3104f6dcffe47fe49466cb3</originalsourceid><addsrcrecordid>eNp1kc1uEzEUhS1ERX9gwQsgS2xgMa09NvbMCqG0IZVCuwDWljO-blx5xsGeScmuj8Az8iR4kjYqSFiy7pXvp6PrcxB6TckpzefMhPaUckHpM3SUKysoK8XzbV8WVU3KQ3Sc0i0hhLNKvkCHjFdClDU_QjDVqXfdDZ78vv-1glXvDOC19gMkrNuQB9oED6mBrk_YdbhfAr7SvQud9ngG2vdLrDuDr4Y-uvEZX_zUreu2CP46xDVs0kt0YLVP8OqhnqDv04tvk1kxv_58Ofk0LxpOOC1qy6iRC94wQhiXQGpqWWUklZZZwXVpRAMcjNSMEm6FaawFLvOtuRDNgp2gjzvd1bBowYxLR-3VKrpWx40K2qm_J51bqpuwVnS0RlYkK7x7UIjhRzahV63Ln_dedxCGpEpBJCO1LEf07T_obRhitmWkyooTWX8Yqfc7qokhpQh2vw0lakxP5fTUNr3Mvnm6_p58jCsDZzvgznnY_F9JnV9_2Un-AUZxpkI</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2628407950</pqid></control><display><type>article</type><title>Fasting C‐peptide values among adolescents in the National Health and Nutrition Examination Surveys</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><creator>Soni, Priya Y. ; Wang, Yumin ; Eckert, George J. ; Ismail, Heba M.</creator><creatorcontrib>Soni, Priya Y. ; Wang, Yumin ; Eckert, George J. ; Ismail, Heba M.</creatorcontrib><description>Aim
To report fasting C‐peptide values and variations across demographics in healthy non‐diabetic adolescents included in the National Health and Nutrition Examination Surveys (NHANES) dataset.
Research Design and Methods
In this analysis, we used fasting C‐peptide data from the 1999 to 2004 NHANES dataset for participants aged 12 to <18 years (n = 2063).
Results
The mean ± SE age of the participants was 14.99 ± 0.06 years. The participants included 992 girls and 1071 boys, and more than 80% of participants had a body mass index (BMI) percentile of <85%. Among boys, the most notable finding was the increase in geometric mean C‐peptide level from 0.51 nmol/L at age 12, to 0.65 nmol/L at age 15 years. Among girls, levels fluctuated around a geometric mean of 0.67 nmol/L. Girls had significantly higher mean log‐transformed C‐peptide concentrations than boys (P < 0.0001) after adjusting for age, race and BMI percentile category. After adjusting for age and BMI percentile category, non‐Hispanic Black boys and girls had significantly lower C‐peptide levels than non‐Hispanic White (P = 0.0026 and P = 0.0093) and Mexican American boys and girls (P < 0.0001 and P < 0.0001), respectively. Despite these findings, both insulin and homeostatic model assessment of insulin resistance were greater in non‐Hispanic Black compared to non‐Hispanic White participants.
Conclusions
Here we describe fasting C‐peptide levels in a non‐diabetic adolescent population. These data provide crucial insight into evaluating racial differences in endogenous insulin release and clearance and will provide novel information which can be used in assessing residual β‐cell function and response to intervention therapy.</description><identifier>ISSN: 1462-8902</identifier><identifier>EISSN: 1463-1326</identifier><identifier>DOI: 10.1111/dom.14611</identifier><identifier>PMID: 34866294</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adolescent ; Adolescents ; Age ; Beta cells ; Body Mass Index ; C-Peptide ; Child ; Children & youth ; Demography ; Diabetes ; Diabetes mellitus ; Fasting ; Female ; Girls ; Hispanic people ; Humans ; Insulin ; Insulin resistance ; Laboratory testing ; Male ; NHANES ; Nutrition Surveys ; Peptides ; Teenagers ; White People ; β‐cell</subject><ispartof>Diabetes, obesity & metabolism, 2022-03, Vol.24 (3), p.539-545</ispartof><rights>2021 John Wiley & Sons Ltd.</rights><rights>2022 John Wiley & Sons Ltd</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c4041-9f31d7b4c300347e091f38d717f3f64a2d6ce4ed7a3104f6dcffe47fe49466cb3</cites><orcidid>0000-0003-0102-0030</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fdom.14611$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fdom.14611$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,780,784,885,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34866294$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Soni, Priya Y.</creatorcontrib><creatorcontrib>Wang, Yumin</creatorcontrib><creatorcontrib>Eckert, George J.</creatorcontrib><creatorcontrib>Ismail, Heba M.</creatorcontrib><title>Fasting C‐peptide values among adolescents in the National Health and Nutrition Examination Surveys</title><title>Diabetes, obesity & metabolism</title><addtitle>Diabetes Obes Metab</addtitle><description>Aim
To report fasting C‐peptide values and variations across demographics in healthy non‐diabetic adolescents included in the National Health and Nutrition Examination Surveys (NHANES) dataset.
Research Design and Methods
In this analysis, we used fasting C‐peptide data from the 1999 to 2004 NHANES dataset for participants aged 12 to <18 years (n = 2063).
Results
The mean ± SE age of the participants was 14.99 ± 0.06 years. The participants included 992 girls and 1071 boys, and more than 80% of participants had a body mass index (BMI) percentile of <85%. Among boys, the most notable finding was the increase in geometric mean C‐peptide level from 0.51 nmol/L at age 12, to 0.65 nmol/L at age 15 years. Among girls, levels fluctuated around a geometric mean of 0.67 nmol/L. Girls had significantly higher mean log‐transformed C‐peptide concentrations than boys (P < 0.0001) after adjusting for age, race and BMI percentile category. After adjusting for age and BMI percentile category, non‐Hispanic Black boys and girls had significantly lower C‐peptide levels than non‐Hispanic White (P = 0.0026 and P = 0.0093) and Mexican American boys and girls (P < 0.0001 and P < 0.0001), respectively. Despite these findings, both insulin and homeostatic model assessment of insulin resistance were greater in non‐Hispanic Black compared to non‐Hispanic White participants.
Conclusions
Here we describe fasting C‐peptide levels in a non‐diabetic adolescent population. These data provide crucial insight into evaluating racial differences in endogenous insulin release and clearance and will provide novel information which can be used in assessing residual β‐cell function and response to intervention therapy.</description><subject>Adolescent</subject><subject>Adolescents</subject><subject>Age</subject><subject>Beta cells</subject><subject>Body Mass Index</subject><subject>C-Peptide</subject><subject>Child</subject><subject>Children & youth</subject><subject>Demography</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Fasting</subject><subject>Female</subject><subject>Girls</subject><subject>Hispanic people</subject><subject>Humans</subject><subject>Insulin</subject><subject>Insulin resistance</subject><subject>Laboratory testing</subject><subject>Male</subject><subject>NHANES</subject><subject>Nutrition Surveys</subject><subject>Peptides</subject><subject>Teenagers</subject><subject>White People</subject><subject>β‐cell</subject><issn>1462-8902</issn><issn>1463-1326</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kc1uEzEUhS1ERX9gwQsgS2xgMa09NvbMCqG0IZVCuwDWljO-blx5xsGeScmuj8Az8iR4kjYqSFiy7pXvp6PrcxB6TckpzefMhPaUckHpM3SUKysoK8XzbV8WVU3KQ3Sc0i0hhLNKvkCHjFdClDU_QjDVqXfdDZ78vv-1glXvDOC19gMkrNuQB9oED6mBrk_YdbhfAr7SvQud9ngG2vdLrDuDr4Y-uvEZX_zUreu2CP46xDVs0kt0YLVP8OqhnqDv04tvk1kxv_58Ofk0LxpOOC1qy6iRC94wQhiXQGpqWWUklZZZwXVpRAMcjNSMEm6FaawFLvOtuRDNgp2gjzvd1bBowYxLR-3VKrpWx40K2qm_J51bqpuwVnS0RlYkK7x7UIjhRzahV63Ln_dedxCGpEpBJCO1LEf07T_obRhitmWkyooTWX8Yqfc7qokhpQh2vw0lakxP5fTUNr3Mvnm6_p58jCsDZzvgznnY_F9JnV9_2Un-AUZxpkI</recordid><startdate>202203</startdate><enddate>202203</enddate><creator>Soni, Priya Y.</creator><creator>Wang, Yumin</creator><creator>Eckert, George J.</creator><creator>Ismail, Heba M.</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-0102-0030</orcidid></search><sort><creationdate>202203</creationdate><title>Fasting C‐peptide values among adolescents in the National Health and Nutrition Examination Surveys</title><author>Soni, Priya Y. ; Wang, Yumin ; Eckert, George J. ; Ismail, Heba M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4041-9f31d7b4c300347e091f38d717f3f64a2d6ce4ed7a3104f6dcffe47fe49466cb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Adolescent</topic><topic>Adolescents</topic><topic>Age</topic><topic>Beta cells</topic><topic>Body Mass Index</topic><topic>C-Peptide</topic><topic>Child</topic><topic>Children & youth</topic><topic>Demography</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>Fasting</topic><topic>Female</topic><topic>Girls</topic><topic>Hispanic people</topic><topic>Humans</topic><topic>Insulin</topic><topic>Insulin resistance</topic><topic>Laboratory testing</topic><topic>Male</topic><topic>NHANES</topic><topic>Nutrition Surveys</topic><topic>Peptides</topic><topic>Teenagers</topic><topic>White People</topic><topic>β‐cell</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Soni, Priya Y.</creatorcontrib><creatorcontrib>Wang, Yumin</creatorcontrib><creatorcontrib>Eckert, George J.</creatorcontrib><creatorcontrib>Ismail, Heba M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Diabetes, obesity & metabolism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Soni, Priya Y.</au><au>Wang, Yumin</au><au>Eckert, George J.</au><au>Ismail, Heba M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Fasting C‐peptide values among adolescents in the National Health and Nutrition Examination Surveys</atitle><jtitle>Diabetes, obesity & metabolism</jtitle><addtitle>Diabetes Obes Metab</addtitle><date>2022-03</date><risdate>2022</risdate><volume>24</volume><issue>3</issue><spage>539</spage><epage>545</epage><pages>539-545</pages><issn>1462-8902</issn><eissn>1463-1326</eissn><abstract>Aim
To report fasting C‐peptide values and variations across demographics in healthy non‐diabetic adolescents included in the National Health and Nutrition Examination Surveys (NHANES) dataset.
Research Design and Methods
In this analysis, we used fasting C‐peptide data from the 1999 to 2004 NHANES dataset for participants aged 12 to <18 years (n = 2063).
Results
The mean ± SE age of the participants was 14.99 ± 0.06 years. The participants included 992 girls and 1071 boys, and more than 80% of participants had a body mass index (BMI) percentile of <85%. Among boys, the most notable finding was the increase in geometric mean C‐peptide level from 0.51 nmol/L at age 12, to 0.65 nmol/L at age 15 years. Among girls, levels fluctuated around a geometric mean of 0.67 nmol/L. Girls had significantly higher mean log‐transformed C‐peptide concentrations than boys (P < 0.0001) after adjusting for age, race and BMI percentile category. After adjusting for age and BMI percentile category, non‐Hispanic Black boys and girls had significantly lower C‐peptide levels than non‐Hispanic White (P = 0.0026 and P = 0.0093) and Mexican American boys and girls (P < 0.0001 and P < 0.0001), respectively. Despite these findings, both insulin and homeostatic model assessment of insulin resistance were greater in non‐Hispanic Black compared to non‐Hispanic White participants.
Conclusions
Here we describe fasting C‐peptide levels in a non‐diabetic adolescent population. These data provide crucial insight into evaluating racial differences in endogenous insulin release and clearance and will provide novel information which can be used in assessing residual β‐cell function and response to intervention therapy.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>34866294</pmid><doi>10.1111/dom.14611</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0003-0102-0030</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Adolescents Age Beta cells Body Mass Index C-Peptide Child Children & youth Demography Diabetes Diabetes mellitus Fasting Female Girls Hispanic people Humans Insulin Insulin resistance Laboratory testing Male NHANES Nutrition Surveys Peptides Teenagers White People β‐cell |
| title | Fasting C‐peptide values among adolescents in the National Health and Nutrition Examination Surveys |
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