Safety and Tolerability of Antimicrobial Agents in the Older Patient
Older patients are at high risk of infections, which often present atypically and are associated with high morbidity and mortality. Antimicrobial treatment in older individuals with infectious diseases represents a clinical challenge, causing an increasing burden on worldwide healthcare systems; imm...
Gespeichert in:
| Veröffentlicht in: | Drugs & aging 2023-06, Vol.40 (6), p.499-526 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 526 |
|---|---|
| container_issue | 6 |
| container_start_page | 499 |
| container_title | Drugs & aging |
| container_volume | 40 |
| creator | Soraci, Luca Cherubini, Antonio Paoletti, Luca Filippelli, Gianfranco Luciani, Filippo Laganà, Pasqualina Gambuzza, Maria Elsa Filicetti, Elvira Corsonello, Andrea Lattanzio, Fabrizia |
| description | Older patients are at high risk of infections, which often present atypically and are associated with high morbidity and mortality. Antimicrobial treatment in older individuals with infectious diseases represents a clinical challenge, causing an increasing burden on worldwide healthcare systems; immunosenescence and the coexistence of multiple comorbidities determine complex polypharmacy regimens with an increase in drug–drug interactions and spread of multidrug-resistance infections. Aging-induced pharmacokinetic and pharmacodynamic changes can additionally increase the risk of inappropriate drug dosing, with underexposure that is associated with antimicrobial resistance and overexposure that may lead to adverse effects and poor adherence because of low tolerability. These issues need to be considered when starting antimicrobial prescriptions. National and international efforts have been made towards the implementation of antimicrobial stewardship (AMS) interventions to help clinicians improve the appropriateness and safety of antimicrobial prescriptions in both acute and long-term care settings. AMS programs were shown to decrease consumption of antimicrobials and to improve safety in hospitalized patients and older nursing home residents. With the abundance of antimicrobial prescriptions and the recent emergence of multidrug resistant pathogens, an in-depth review of antimicrobial prescriptions in geriatric clinical practice is needed. This review will discuss the special considerations for older individuals needing antimicrobials, including risk factors that shape risk profiles in geriatric populations as well as an evidence-based description of antimicrobial-induced adverse events in this patient population. It will highlight agents of concern for this age group and discuss interventions to mitigate the effects of inappropriate antimicrobial prescribing. |
| doi_str_mv | 10.1007/s40266-023-01019-3 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10043546</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2792901153</sourcerecordid><originalsourceid>FETCH-LOGICAL-c475t-d286f6b6cf907b4e9ea834889c2298da1aa846695aa1b09a5af6dc94484a3ccc3</originalsourceid><addsrcrecordid>eNp9kclOwzAQhi0EoqXwAhxQJC5cAt7ixCdUlVWqBBJF4mZNHKd1lSbFTpH69rgLZTlw8mjm8z_Lj9ApwZcE4_TKc0yFiDFlMSaYyJjtoS4hqYyJFHJ_HeOYUvnWQUfeTzHGglJyiDpMyFQkmHTRzQuUpl1GUBfRqKmMg9xWNiSaMurXrZ1Z7ZrcQhX1x6ZufWTrqJ2Y6KkqjIueobUhe4wOSqi8Odm-PfR6dzsaPMTDp_vHQX8Ya54mbVzQTJQiF7qUOM25kQYyxrNM6jBjVgAByLgQMgEgOZaQQCkKLTnPODCtNeuh643ufJHPTKFDaweVmjs7A7dUDVj1u1LbiRo3Hyqci7OEi6BwsVVwzfvC-FbNrNemqqA2zcIrmkoqMSEJC-j5H3TaLFwd9lM0o0RImlAaKLqhwpm8d6bcTUPwqm2qNi6p4JJau6RW0mc_99h9-bIlAGwD-FCqx8Z99_5H9hPyOp0r</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2821692522</pqid></control><display><type>article</type><title>Safety and Tolerability of Antimicrobial Agents in the Older Patient</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>Soraci, Luca ; Cherubini, Antonio ; Paoletti, Luca ; Filippelli, Gianfranco ; Luciani, Filippo ; Laganà, Pasqualina ; Gambuzza, Maria Elsa ; Filicetti, Elvira ; Corsonello, Andrea ; Lattanzio, Fabrizia</creator><creatorcontrib>Soraci, Luca ; Cherubini, Antonio ; Paoletti, Luca ; Filippelli, Gianfranco ; Luciani, Filippo ; Laganà, Pasqualina ; Gambuzza, Maria Elsa ; Filicetti, Elvira ; Corsonello, Andrea ; Lattanzio, Fabrizia</creatorcontrib><description>Older patients are at high risk of infections, which often present atypically and are associated with high morbidity and mortality. Antimicrobial treatment in older individuals with infectious diseases represents a clinical challenge, causing an increasing burden on worldwide healthcare systems; immunosenescence and the coexistence of multiple comorbidities determine complex polypharmacy regimens with an increase in drug–drug interactions and spread of multidrug-resistance infections. Aging-induced pharmacokinetic and pharmacodynamic changes can additionally increase the risk of inappropriate drug dosing, with underexposure that is associated with antimicrobial resistance and overexposure that may lead to adverse effects and poor adherence because of low tolerability. These issues need to be considered when starting antimicrobial prescriptions. National and international efforts have been made towards the implementation of antimicrobial stewardship (AMS) interventions to help clinicians improve the appropriateness and safety of antimicrobial prescriptions in both acute and long-term care settings. AMS programs were shown to decrease consumption of antimicrobials and to improve safety in hospitalized patients and older nursing home residents. With the abundance of antimicrobial prescriptions and the recent emergence of multidrug resistant pathogens, an in-depth review of antimicrobial prescriptions in geriatric clinical practice is needed. This review will discuss the special considerations for older individuals needing antimicrobials, including risk factors that shape risk profiles in geriatric populations as well as an evidence-based description of antimicrobial-induced adverse events in this patient population. It will highlight agents of concern for this age group and discuss interventions to mitigate the effects of inappropriate antimicrobial prescribing.</description><identifier>ISSN: 1170-229X</identifier><identifier>EISSN: 1179-1969</identifier><identifier>DOI: 10.1007/s40266-023-01019-3</identifier><identifier>PMID: 36976501</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Aged ; Aging ; Anti-Bacterial Agents - adverse effects ; Anti-Infective Agents - adverse effects ; Antibiotics ; Antimicrobial agents ; Antimicrobial Stewardship ; Bioavailability ; Blood-brain barrier ; Drug interactions ; Drug-Related Side Effects and Adverse Reactions - drug therapy ; Esophagus ; Geriatrics ; Geriatrics/Gerontology ; Humans ; Hypoglycemia ; Inappropriate Prescribing ; Infections ; Internal Medicine ; Long-Term Care ; Medicine ; Medicine & Public Health ; Metabolism ; Mortality ; Older people ; Patients ; Pharmacodynamics ; Pharmacokinetics ; Pharmacology/Toxicology ; Pharmacotherapy ; Plasma ; Polypharmacy ; Prescription drugs ; Proteins ; Review ; Review Article ; Toxicity</subject><ispartof>Drugs & aging, 2023-06, Vol.40 (6), p.499-526</ispartof><rights>The Author(s), under exclusive licence to Springer Nature Switzerland AG 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2023. The Author(s), under exclusive licence to Springer Nature Switzerland AG.</rights><rights>Copyright Springer Nature B.V. Jun 2023</rights><rights>The Author(s), under exclusive licence to Springer Nature Switzerland AG 2023, Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c475t-d286f6b6cf907b4e9ea834889c2298da1aa846695aa1b09a5af6dc94484a3ccc3</citedby><cites>FETCH-LOGICAL-c475t-d286f6b6cf907b4e9ea834889c2298da1aa846695aa1b09a5af6dc94484a3ccc3</cites><orcidid>0000-0002-7276-3256</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s40266-023-01019-3$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s40266-023-01019-3$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,780,784,885,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36976501$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Soraci, Luca</creatorcontrib><creatorcontrib>Cherubini, Antonio</creatorcontrib><creatorcontrib>Paoletti, Luca</creatorcontrib><creatorcontrib>Filippelli, Gianfranco</creatorcontrib><creatorcontrib>Luciani, Filippo</creatorcontrib><creatorcontrib>Laganà, Pasqualina</creatorcontrib><creatorcontrib>Gambuzza, Maria Elsa</creatorcontrib><creatorcontrib>Filicetti, Elvira</creatorcontrib><creatorcontrib>Corsonello, Andrea</creatorcontrib><creatorcontrib>Lattanzio, Fabrizia</creatorcontrib><title>Safety and Tolerability of Antimicrobial Agents in the Older Patient</title><title>Drugs & aging</title><addtitle>Drugs Aging</addtitle><addtitle>Drugs Aging</addtitle><description>Older patients are at high risk of infections, which often present atypically and are associated with high morbidity and mortality. Antimicrobial treatment in older individuals with infectious diseases represents a clinical challenge, causing an increasing burden on worldwide healthcare systems; immunosenescence and the coexistence of multiple comorbidities determine complex polypharmacy regimens with an increase in drug–drug interactions and spread of multidrug-resistance infections. Aging-induced pharmacokinetic and pharmacodynamic changes can additionally increase the risk of inappropriate drug dosing, with underexposure that is associated with antimicrobial resistance and overexposure that may lead to adverse effects and poor adherence because of low tolerability. These issues need to be considered when starting antimicrobial prescriptions. National and international efforts have been made towards the implementation of antimicrobial stewardship (AMS) interventions to help clinicians improve the appropriateness and safety of antimicrobial prescriptions in both acute and long-term care settings. AMS programs were shown to decrease consumption of antimicrobials and to improve safety in hospitalized patients and older nursing home residents. With the abundance of antimicrobial prescriptions and the recent emergence of multidrug resistant pathogens, an in-depth review of antimicrobial prescriptions in geriatric clinical practice is needed. This review will discuss the special considerations for older individuals needing antimicrobials, including risk factors that shape risk profiles in geriatric populations as well as an evidence-based description of antimicrobial-induced adverse events in this patient population. It will highlight agents of concern for this age group and discuss interventions to mitigate the effects of inappropriate antimicrobial prescribing.</description><subject>Aged</subject><subject>Aging</subject><subject>Anti-Bacterial Agents - adverse effects</subject><subject>Anti-Infective Agents - adverse effects</subject><subject>Antibiotics</subject><subject>Antimicrobial agents</subject><subject>Antimicrobial Stewardship</subject><subject>Bioavailability</subject><subject>Blood-brain barrier</subject><subject>Drug interactions</subject><subject>Drug-Related Side Effects and Adverse Reactions - drug therapy</subject><subject>Esophagus</subject><subject>Geriatrics</subject><subject>Geriatrics/Gerontology</subject><subject>Humans</subject><subject>Hypoglycemia</subject><subject>Inappropriate Prescribing</subject><subject>Infections</subject><subject>Internal Medicine</subject><subject>Long-Term Care</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolism</subject><subject>Mortality</subject><subject>Older people</subject><subject>Patients</subject><subject>Pharmacodynamics</subject><subject>Pharmacokinetics</subject><subject>Pharmacology/Toxicology</subject><subject>Pharmacotherapy</subject><subject>Plasma</subject><subject>Polypharmacy</subject><subject>Prescription drugs</subject><subject>Proteins</subject><subject>Review</subject><subject>Review Article</subject><subject>Toxicity</subject><issn>1170-229X</issn><issn>1179-1969</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kclOwzAQhi0EoqXwAhxQJC5cAt7ixCdUlVWqBBJF4mZNHKd1lSbFTpH69rgLZTlw8mjm8z_Lj9ApwZcE4_TKc0yFiDFlMSaYyJjtoS4hqYyJFHJ_HeOYUvnWQUfeTzHGglJyiDpMyFQkmHTRzQuUpl1GUBfRqKmMg9xWNiSaMurXrZ1Z7ZrcQhX1x6ZufWTrqJ2Y6KkqjIueobUhe4wOSqi8Odm-PfR6dzsaPMTDp_vHQX8Ya54mbVzQTJQiF7qUOM25kQYyxrNM6jBjVgAByLgQMgEgOZaQQCkKLTnPODCtNeuh643ufJHPTKFDaweVmjs7A7dUDVj1u1LbiRo3Hyqci7OEi6BwsVVwzfvC-FbNrNemqqA2zcIrmkoqMSEJC-j5H3TaLFwd9lM0o0RImlAaKLqhwpm8d6bcTUPwqm2qNi6p4JJau6RW0mc_99h9-bIlAGwD-FCqx8Z99_5H9hPyOp0r</recordid><startdate>20230601</startdate><enddate>20230601</enddate><creator>Soraci, Luca</creator><creator>Cherubini, Antonio</creator><creator>Paoletti, Luca</creator><creator>Filippelli, Gianfranco</creator><creator>Luciani, Filippo</creator><creator>Laganà, Pasqualina</creator><creator>Gambuzza, Maria Elsa</creator><creator>Filicetti, Elvira</creator><creator>Corsonello, Andrea</creator><creator>Lattanzio, Fabrizia</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>4T-</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-7276-3256</orcidid></search><sort><creationdate>20230601</creationdate><title>Safety and Tolerability of Antimicrobial Agents in the Older Patient</title><author>Soraci, Luca ; Cherubini, Antonio ; Paoletti, Luca ; Filippelli, Gianfranco ; Luciani, Filippo ; Laganà, Pasqualina ; Gambuzza, Maria Elsa ; Filicetti, Elvira ; Corsonello, Andrea ; Lattanzio, Fabrizia</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c475t-d286f6b6cf907b4e9ea834889c2298da1aa846695aa1b09a5af6dc94484a3ccc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Aged</topic><topic>Aging</topic><topic>Anti-Bacterial Agents - adverse effects</topic><topic>Anti-Infective Agents - adverse effects</topic><topic>Antibiotics</topic><topic>Antimicrobial agents</topic><topic>Antimicrobial Stewardship</topic><topic>Bioavailability</topic><topic>Blood-brain barrier</topic><topic>Drug interactions</topic><topic>Drug-Related Side Effects and Adverse Reactions - drug therapy</topic><topic>Esophagus</topic><topic>Geriatrics</topic><topic>Geriatrics/Gerontology</topic><topic>Humans</topic><topic>Hypoglycemia</topic><topic>Inappropriate Prescribing</topic><topic>Infections</topic><topic>Internal Medicine</topic><topic>Long-Term Care</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metabolism</topic><topic>Mortality</topic><topic>Older people</topic><topic>Patients</topic><topic>Pharmacodynamics</topic><topic>Pharmacokinetics</topic><topic>Pharmacology/Toxicology</topic><topic>Pharmacotherapy</topic><topic>Plasma</topic><topic>Polypharmacy</topic><topic>Prescription drugs</topic><topic>Proteins</topic><topic>Review</topic><topic>Review Article</topic><topic>Toxicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Soraci, Luca</creatorcontrib><creatorcontrib>Cherubini, Antonio</creatorcontrib><creatorcontrib>Paoletti, Luca</creatorcontrib><creatorcontrib>Filippelli, Gianfranco</creatorcontrib><creatorcontrib>Luciani, Filippo</creatorcontrib><creatorcontrib>Laganà, Pasqualina</creatorcontrib><creatorcontrib>Gambuzza, Maria Elsa</creatorcontrib><creatorcontrib>Filicetti, Elvira</creatorcontrib><creatorcontrib>Corsonello, Andrea</creatorcontrib><creatorcontrib>Lattanzio, Fabrizia</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Docstoc</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Drugs & aging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Soraci, Luca</au><au>Cherubini, Antonio</au><au>Paoletti, Luca</au><au>Filippelli, Gianfranco</au><au>Luciani, Filippo</au><au>Laganà, Pasqualina</au><au>Gambuzza, Maria Elsa</au><au>Filicetti, Elvira</au><au>Corsonello, Andrea</au><au>Lattanzio, Fabrizia</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Safety and Tolerability of Antimicrobial Agents in the Older Patient</atitle><jtitle>Drugs & aging</jtitle><stitle>Drugs Aging</stitle><addtitle>Drugs Aging</addtitle><date>2023-06-01</date><risdate>2023</risdate><volume>40</volume><issue>6</issue><spage>499</spage><epage>526</epage><pages>499-526</pages><issn>1170-229X</issn><eissn>1179-1969</eissn><abstract>Older patients are at high risk of infections, which often present atypically and are associated with high morbidity and mortality. Antimicrobial treatment in older individuals with infectious diseases represents a clinical challenge, causing an increasing burden on worldwide healthcare systems; immunosenescence and the coexistence of multiple comorbidities determine complex polypharmacy regimens with an increase in drug–drug interactions and spread of multidrug-resistance infections. Aging-induced pharmacokinetic and pharmacodynamic changes can additionally increase the risk of inappropriate drug dosing, with underexposure that is associated with antimicrobial resistance and overexposure that may lead to adverse effects and poor adherence because of low tolerability. These issues need to be considered when starting antimicrobial prescriptions. National and international efforts have been made towards the implementation of antimicrobial stewardship (AMS) interventions to help clinicians improve the appropriateness and safety of antimicrobial prescriptions in both acute and long-term care settings. AMS programs were shown to decrease consumption of antimicrobials and to improve safety in hospitalized patients and older nursing home residents. With the abundance of antimicrobial prescriptions and the recent emergence of multidrug resistant pathogens, an in-depth review of antimicrobial prescriptions in geriatric clinical practice is needed. This review will discuss the special considerations for older individuals needing antimicrobials, including risk factors that shape risk profiles in geriatric populations as well as an evidence-based description of antimicrobial-induced adverse events in this patient population. It will highlight agents of concern for this age group and discuss interventions to mitigate the effects of inappropriate antimicrobial prescribing.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>36976501</pmid><doi>10.1007/s40266-023-01019-3</doi><tpages>28</tpages><orcidid>https://orcid.org/0000-0002-7276-3256</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1170-229X |
| ispartof | Drugs & aging, 2023-06, Vol.40 (6), p.499-526 |
| issn | 1170-229X 1179-1969 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10043546 |
| source | MEDLINE; SpringerLink Journals |
| subjects | Aged Aging Anti-Bacterial Agents - adverse effects Anti-Infective Agents - adverse effects Antibiotics Antimicrobial agents Antimicrobial Stewardship Bioavailability Blood-brain barrier Drug interactions Drug-Related Side Effects and Adverse Reactions - drug therapy Esophagus Geriatrics Geriatrics/Gerontology Humans Hypoglycemia Inappropriate Prescribing Infections Internal Medicine Long-Term Care Medicine Medicine & Public Health Metabolism Mortality Older people Patients Pharmacodynamics Pharmacokinetics Pharmacology/Toxicology Pharmacotherapy Plasma Polypharmacy Prescription drugs Proteins Review Review Article Toxicity |
| title | Safety and Tolerability of Antimicrobial Agents in the Older Patient |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-03T12%3A45%3A01IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Safety%20and%20Tolerability%20of%20Antimicrobial%20Agents%20in%20the%20Older%20Patient&rft.jtitle=Drugs%20&%20aging&rft.au=Soraci,%20Luca&rft.date=2023-06-01&rft.volume=40&rft.issue=6&rft.spage=499&rft.epage=526&rft.pages=499-526&rft.issn=1170-229X&rft.eissn=1179-1969&rft_id=info:doi/10.1007/s40266-023-01019-3&rft_dat=%3Cproquest_pubme%3E2792901153%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2821692522&rft_id=info:pmid/36976501&rfr_iscdi=true |