Incubation of Lymphocytes with IL-2 Causes the Appearance of Antitumor T Cells Carrying FC, CD25, and LFA-1 on the Surface
To carry out antitumor activity against cells that have lost surface antigens, human lymphocytes must have a certain repertoire of surface proteins capable of contacting a tumor cell and inducing programmed cell death in it. In this work, we showed that activation of healthy donor cells by IL-2 cyto...
Gespeichert in:
| Veröffentlicht in: | Doklady. Biochemistry and biophysics 2023-02, Vol.508 (1), p.12-16 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 16 |
|---|---|
| container_issue | 1 |
| container_start_page | 12 |
| container_title | Doklady. Biochemistry and biophysics |
| container_volume | 508 |
| creator | Ivanova, O. K. Sharapova, T. N. Romanova, E. A. Yashin, D. V. Sashchenko, L. P. |
| description | To carry out antitumor activity against cells that have lost surface antigens, human lymphocytes must have a certain repertoire of surface proteins capable of contacting a tumor cell and inducing programmed cell death in it. In this work, we showed that activation of healthy donor cells by IL-2 cytokine within 6 days causes the appearance of FasL, CD25, and LFA-1 proteins on CD8+CD25+ T lymphocytes, and also converts the LFA-1 protein into an active form having a high affinity for its target, ICAM-1 integrin. The appearance of these proteins on the surface of this subpopulation of lymphocytes allows them to induce programmed cell death in HLA-negative tumor cells. |
| doi_str_mv | 10.1134/S160767292270003X |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10042969</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2791649069</sourcerecordid><originalsourceid>FETCH-LOGICAL-c423t-359233954bfcc22105d345d3c2110f76ba1d3b32824e81797d913baaa0f7f1593</originalsourceid><addsrcrecordid>eNp1kU1v1DAQhiMEoqXwA7ggS1w4NOAZ58sntApdWCkShxaJm-U4zm6qjR1sp2j59XW6pXyJg2Vr3mfe8ehNkpdA3wKw7N0lFLQsSuSIJaWUfX2UnMZSlTLK4fHdu0wX_SR55v01pUiR5U-TE1YUOcsrPE1-bIyaWxkGa4jtSXMYp51Vh6A9-T6EHdk0KZJazj4Wwk6T1TRp6aRResFXJgxhHq0jV6TW-72PqHOHwWzJuj4n9QfMz4k0HWnWqxRInLF4XM6ul0o_T570cu_1i_v7LPmyvriqP6XN54-betWkKkMWUpZzZIznWdsrhQg071gWj0IA2pdFK6FjLcMKM11BycuOA2ullFHsIefsLHl_9J3mdtSd0iY4uReTG0bpDsLKQfypmGEntvZGAKUZ8mJxeHPv4Oy3WfsgxsGruK802s5eYAwBigoBI_r6L_Tazs7E_SLFocg4vTOEI6Wc9d7p_uE3QMUSrfgn2tjz6vc1Hjp-ZhkBPAI-Smar3a_R_3e9BZvoqv0</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2791649069</pqid></control><display><type>article</type><title>Incubation of Lymphocytes with IL-2 Causes the Appearance of Antitumor T Cells Carrying FC, CD25, and LFA-1 on the Surface</title><source>MEDLINE</source><source>SpringerNature Journals</source><creator>Ivanova, O. K. ; Sharapova, T. N. ; Romanova, E. A. ; Yashin, D. V. ; Sashchenko, L. P.</creator><creatorcontrib>Ivanova, O. K. ; Sharapova, T. N. ; Romanova, E. A. ; Yashin, D. V. ; Sashchenko, L. P.</creatorcontrib><description>To carry out antitumor activity against cells that have lost surface antigens, human lymphocytes must have a certain repertoire of surface proteins capable of contacting a tumor cell and inducing programmed cell death in it. In this work, we showed that activation of healthy donor cells by IL-2 cytokine within 6 days causes the appearance of FasL, CD25, and LFA-1 proteins on CD8+CD25+ T lymphocytes, and also converts the LFA-1 protein into an active form having a high affinity for its target, ICAM-1 integrin. The appearance of these proteins on the surface of this subpopulation of lymphocytes allows them to induce programmed cell death in HLA-negative tumor cells.</description><identifier>ISSN: 1607-6729</identifier><identifier>EISSN: 1608-3091</identifier><identifier>DOI: 10.1134/S160767292270003X</identifier><identifier>PMID: 36653582</identifier><language>eng</language><publisher>Moscow: Pleiades Publishing</publisher><subject>Antigens ; Antitumor activity ; Apoptosis ; Biochemistry ; Biochemistry, Biophysics, and Molecular Biology ; Biological and Medical Physics ; Biomedical and Life Sciences ; Biophysics ; CD25 antigen ; CD8 antigen ; CD8-Positive T-Lymphocytes ; Cell activation ; Cell death ; Cytokines ; FasL protein ; Humans ; Intercellular adhesion molecule 1 ; Interleukin 2 ; Interleukin-2 - metabolism ; LFA-1 antigen ; Life Sciences ; Lymphocyte Function-Associated Antigen-1 - metabolism ; Lymphocytes T ; Molecular Biology ; Surface antigens ; T-Lymphocytes - immunology ; Tumor cells</subject><ispartof>Doklady. Biochemistry and biophysics, 2023-02, Vol.508 (1), p.12-16</ispartof><rights>The Author(s) 2023. ISSN 1607-6729, Doklady Biochemistry and Biophysics, 2023, Vol. 508, pp. 12–16. © The Author(s), 2023. This article is an open access publication. ISSN 1607-6729, Doklady Biochemistry and Biophysics, 2022. © The Author(s), 2022. This article is an open access publication.</rights><rights>2023. The Author(s).</rights><rights>The Author(s) 2023. ISSN 1607-6729, Doklady Biochemistry and Biophysics, 2023, Vol. 508, pp. 12–16. © The Author(s), 2023. This article is an open access publication. ISSN 1607-6729, Doklady Biochemistry and Biophysics, 2022. © The Author(s), 2022. This article is an open access publication. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>The Author(s) 2023, ISSN 1607-6729, Doklady Biochemistry and Biophysics, 2023, Vol. 508, pp. 12–16. © The Author(s), 2023. This article is an open access publication.ISSN 1607-6729, Doklady Biochemistry and Biophysics, 2022. © The Author(s), 2022. This article is an open access publication.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c423t-359233954bfcc22105d345d3c2110f76ba1d3b32824e81797d913baaa0f7f1593</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1134/S160767292270003X$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1134/S160767292270003X$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,780,784,885,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36653582$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ivanova, O. K.</creatorcontrib><creatorcontrib>Sharapova, T. N.</creatorcontrib><creatorcontrib>Romanova, E. A.</creatorcontrib><creatorcontrib>Yashin, D. V.</creatorcontrib><creatorcontrib>Sashchenko, L. P.</creatorcontrib><title>Incubation of Lymphocytes with IL-2 Causes the Appearance of Antitumor T Cells Carrying FC, CD25, and LFA-1 on the Surface</title><title>Doklady. Biochemistry and biophysics</title><addtitle>Dokl Biochem Biophys</addtitle><addtitle>Dokl Biochem Biophys</addtitle><description>To carry out antitumor activity against cells that have lost surface antigens, human lymphocytes must have a certain repertoire of surface proteins capable of contacting a tumor cell and inducing programmed cell death in it. In this work, we showed that activation of healthy donor cells by IL-2 cytokine within 6 days causes the appearance of FasL, CD25, and LFA-1 proteins on CD8+CD25+ T lymphocytes, and also converts the LFA-1 protein into an active form having a high affinity for its target, ICAM-1 integrin. The appearance of these proteins on the surface of this subpopulation of lymphocytes allows them to induce programmed cell death in HLA-negative tumor cells.</description><subject>Antigens</subject><subject>Antitumor activity</subject><subject>Apoptosis</subject><subject>Biochemistry</subject><subject>Biochemistry, Biophysics, and Molecular Biology</subject><subject>Biological and Medical Physics</subject><subject>Biomedical and Life Sciences</subject><subject>Biophysics</subject><subject>CD25 antigen</subject><subject>CD8 antigen</subject><subject>CD8-Positive T-Lymphocytes</subject><subject>Cell activation</subject><subject>Cell death</subject><subject>Cytokines</subject><subject>FasL protein</subject><subject>Humans</subject><subject>Intercellular adhesion molecule 1</subject><subject>Interleukin 2</subject><subject>Interleukin-2 - metabolism</subject><subject>LFA-1 antigen</subject><subject>Life Sciences</subject><subject>Lymphocyte Function-Associated Antigen-1 - metabolism</subject><subject>Lymphocytes T</subject><subject>Molecular Biology</subject><subject>Surface antigens</subject><subject>T-Lymphocytes - immunology</subject><subject>Tumor cells</subject><issn>1607-6729</issn><issn>1608-3091</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><recordid>eNp1kU1v1DAQhiMEoqXwA7ggS1w4NOAZ58sntApdWCkShxaJm-U4zm6qjR1sp2j59XW6pXyJg2Vr3mfe8ehNkpdA3wKw7N0lFLQsSuSIJaWUfX2UnMZSlTLK4fHdu0wX_SR55v01pUiR5U-TE1YUOcsrPE1-bIyaWxkGa4jtSXMYp51Vh6A9-T6EHdk0KZJazj4Wwk6T1TRp6aRResFXJgxhHq0jV6TW-72PqHOHwWzJuj4n9QfMz4k0HWnWqxRInLF4XM6ul0o_T570cu_1i_v7LPmyvriqP6XN54-betWkKkMWUpZzZIznWdsrhQg071gWj0IA2pdFK6FjLcMKM11BycuOA2ullFHsIefsLHl_9J3mdtSd0iY4uReTG0bpDsLKQfypmGEntvZGAKUZ8mJxeHPv4Oy3WfsgxsGruK802s5eYAwBigoBI_r6L_Tazs7E_SLFocg4vTOEI6Wc9d7p_uE3QMUSrfgn2tjz6vc1Hjp-ZhkBPAI-Smar3a_R_3e9BZvoqv0</recordid><startdate>20230201</startdate><enddate>20230201</enddate><creator>Ivanova, O. K.</creator><creator>Sharapova, T. N.</creator><creator>Romanova, E. A.</creator><creator>Yashin, D. V.</creator><creator>Sashchenko, L. P.</creator><general>Pleiades Publishing</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>P64</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20230201</creationdate><title>Incubation of Lymphocytes with IL-2 Causes the Appearance of Antitumor T Cells Carrying FC, CD25, and LFA-1 on the Surface</title><author>Ivanova, O. K. ; Sharapova, T. N. ; Romanova, E. A. ; Yashin, D. V. ; Sashchenko, L. P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c423t-359233954bfcc22105d345d3c2110f76ba1d3b32824e81797d913baaa0f7f1593</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Antigens</topic><topic>Antitumor activity</topic><topic>Apoptosis</topic><topic>Biochemistry</topic><topic>Biochemistry, Biophysics, and Molecular Biology</topic><topic>Biological and Medical Physics</topic><topic>Biomedical and Life Sciences</topic><topic>Biophysics</topic><topic>CD25 antigen</topic><topic>CD8 antigen</topic><topic>CD8-Positive T-Lymphocytes</topic><topic>Cell activation</topic><topic>Cell death</topic><topic>Cytokines</topic><topic>FasL protein</topic><topic>Humans</topic><topic>Intercellular adhesion molecule 1</topic><topic>Interleukin 2</topic><topic>Interleukin-2 - metabolism</topic><topic>LFA-1 antigen</topic><topic>Life Sciences</topic><topic>Lymphocyte Function-Associated Antigen-1 - metabolism</topic><topic>Lymphocytes T</topic><topic>Molecular Biology</topic><topic>Surface antigens</topic><topic>T-Lymphocytes - immunology</topic><topic>Tumor cells</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ivanova, O. K.</creatorcontrib><creatorcontrib>Sharapova, T. N.</creatorcontrib><creatorcontrib>Romanova, E. A.</creatorcontrib><creatorcontrib>Yashin, D. V.</creatorcontrib><creatorcontrib>Sashchenko, L. P.</creatorcontrib><collection>Springer Nature OA/Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Doklady. Biochemistry and biophysics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ivanova, O. K.</au><au>Sharapova, T. N.</au><au>Romanova, E. A.</au><au>Yashin, D. V.</au><au>Sashchenko, L. P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Incubation of Lymphocytes with IL-2 Causes the Appearance of Antitumor T Cells Carrying FC, CD25, and LFA-1 on the Surface</atitle><jtitle>Doklady. Biochemistry and biophysics</jtitle><stitle>Dokl Biochem Biophys</stitle><addtitle>Dokl Biochem Biophys</addtitle><date>2023-02-01</date><risdate>2023</risdate><volume>508</volume><issue>1</issue><spage>12</spage><epage>16</epage><pages>12-16</pages><issn>1607-6729</issn><eissn>1608-3091</eissn><abstract>To carry out antitumor activity against cells that have lost surface antigens, human lymphocytes must have a certain repertoire of surface proteins capable of contacting a tumor cell and inducing programmed cell death in it. In this work, we showed that activation of healthy donor cells by IL-2 cytokine within 6 days causes the appearance of FasL, CD25, and LFA-1 proteins on CD8+CD25+ T lymphocytes, and also converts the LFA-1 protein into an active form having a high affinity for its target, ICAM-1 integrin. The appearance of these proteins on the surface of this subpopulation of lymphocytes allows them to induce programmed cell death in HLA-negative tumor cells.</abstract><cop>Moscow</cop><pub>Pleiades Publishing</pub><pmid>36653582</pmid><doi>10.1134/S160767292270003X</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1607-6729 |
| ispartof | Doklady. Biochemistry and biophysics, 2023-02, Vol.508 (1), p.12-16 |
| issn | 1607-6729 1608-3091 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10042969 |
| source | MEDLINE; SpringerNature Journals |
| subjects | Antigens Antitumor activity Apoptosis Biochemistry Biochemistry, Biophysics, and Molecular Biology Biological and Medical Physics Biomedical and Life Sciences Biophysics CD25 antigen CD8 antigen CD8-Positive T-Lymphocytes Cell activation Cell death Cytokines FasL protein Humans Intercellular adhesion molecule 1 Interleukin 2 Interleukin-2 - metabolism LFA-1 antigen Life Sciences Lymphocyte Function-Associated Antigen-1 - metabolism Lymphocytes T Molecular Biology Surface antigens T-Lymphocytes - immunology Tumor cells |
| title | Incubation of Lymphocytes with IL-2 Causes the Appearance of Antitumor T Cells Carrying FC, CD25, and LFA-1 on the Surface |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-28T18%3A40%3A20IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Incubation%20of%20Lymphocytes%20with%20IL-2%20Causes%20the%20Appearance%20of%20Antitumor%20T%20Cells%20Carrying%20FC,%20CD25,%20and%20LFA-1%20on%20the%20Surface&rft.jtitle=Doklady.%20Biochemistry%20and%20biophysics&rft.au=Ivanova,%20O.%20K.&rft.date=2023-02-01&rft.volume=508&rft.issue=1&rft.spage=12&rft.epage=16&rft.pages=12-16&rft.issn=1607-6729&rft.eissn=1608-3091&rft_id=info:doi/10.1134/S160767292270003X&rft_dat=%3Cproquest_pubme%3E2791649069%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2791649069&rft_id=info:pmid/36653582&rfr_iscdi=true |