Antimicrobial efficacy and inactivation kinetics of a novel LED-based UV-irradiation technology
Ultraviolet (UV)-light-emitting diodes (UV-LEDs) are energy efficient and of special interest for the inactivation of micro-organisms. In the context of the coronavirus disease 2019 pandemic, novel UV technologies can offer a powerful alternative for effective infection prevention and control. This...
Gespeichert in:
| Veröffentlicht in: | The Journal of hospital infection 2023-05, Vol.135, p.11-17 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 17 |
|---|---|
| container_issue | |
| container_start_page | 11 |
| container_title | The Journal of hospital infection |
| container_volume | 135 |
| creator | Schöbel, H. Diem, G. Kiechl, J. Chistè, D. Bertacchi, G. Mayr, A. Wilflingseder, D. Lass-Flörl, C. Posch, W. |
| description | Ultraviolet (UV)-light-emitting diodes (UV-LEDs) are energy efficient and of special interest for the inactivation of micro-organisms. In the context of the coronavirus disease 2019 pandemic, novel UV technologies can offer a powerful alternative for effective infection prevention and control.
This study assessed the antimicrobial efficacy of UV-C LEDs on Escherichia coli, Pseudomonas fluorescens and Listeria innocua, as well as severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), human immunodeficiency virus-1 (HIV-1) and murine norovirus (MNV), dried on inanimate surfaces, based on European Standard EN 17272.
This study found 90% inactivation rates for the tested bacteria at mean UV-C doses, averaged over all three investigated UV-C wavelengths, of 1.7 mJ/cm2 for E. coli, 1.9 mJ/cm2 for P. fluorescens and 1.5 mJ/cm2 for L. innocua. For the tested viruses, UV doses |
| doi_str_mv | 10.1016/j.jhin.2022.12.023 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10041887</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0195670123000361</els_id><sourcerecordid>2774896561</sourcerecordid><originalsourceid>FETCH-LOGICAL-c456t-584cd18a8ef2aea3f5df84c5d825b17c1056423559d7e155a533fdaae7c458e23</originalsourceid><addsrcrecordid>eNp9kcFuEzEQhi0EomnhBTigPXLZxfaud70SEqpKC0iRuLS9WhN73EzY2MXeRMrb4yilggsnS-Pv_23Nx9g7wRvBRf9x02zWFBrJpWyEbLhsX7CFUK2s5diOL9mCi1HV_cDFGTvPecM5L3P1mp21_aA6qfWCmcsw05ZsiiuCqULvyYI9VBBcRQHsTHuYKYbqJwWcyeYq-gqqEPc4VcvrL_UKMrrq7r6mlMDRCZ7RrkOc4sPhDXvlYcr49um8YHc317dX3-rlj6_fry6Xte1UP9dKd9YJDRq9BITWK-fLSDkt1UoMVnDVd7JVanQDCqVAta13ADiUvEbZXrDPp97H3WqLzmKYE0zmMdEW0sFEIPPvTaC1eYh7IzjvhNZDafjw1JDirx3m2WwpW5wmCBh32chh6PTYq14UVJ7QsracE_rndwQ3RzVmY45qzFGNEdIUNSX0_u8fPkf-uCjApxOAZU97wmSyJQwWHSW0s3GR_tf_G7RBoeE</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2774896561</pqid></control><display><type>article</type><title>Antimicrobial efficacy and inactivation kinetics of a novel LED-based UV-irradiation technology</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><creator>Schöbel, H. ; Diem, G. ; Kiechl, J. ; Chistè, D. ; Bertacchi, G. ; Mayr, A. ; Wilflingseder, D. ; Lass-Flörl, C. ; Posch, W.</creator><creatorcontrib>Schöbel, H. ; Diem, G. ; Kiechl, J. ; Chistè, D. ; Bertacchi, G. ; Mayr, A. ; Wilflingseder, D. ; Lass-Flörl, C. ; Posch, W.</creatorcontrib><description>Ultraviolet (UV)-light-emitting diodes (UV-LEDs) are energy efficient and of special interest for the inactivation of micro-organisms. In the context of the coronavirus disease 2019 pandemic, novel UV technologies can offer a powerful alternative for effective infection prevention and control.
This study assessed the antimicrobial efficacy of UV-C LEDs on Escherichia coli, Pseudomonas fluorescens and Listeria innocua, as well as severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), human immunodeficiency virus-1 (HIV-1) and murine norovirus (MNV), dried on inanimate surfaces, based on European Standard EN 17272.
This study found 90% inactivation rates for the tested bacteria at mean UV-C doses, averaged over all three investigated UV-C wavelengths, of 1.7 mJ/cm2 for E. coli, 1.9 mJ/cm2 for P. fluorescens and 1.5 mJ/cm2 for L. innocua. For the tested viruses, UV doses <15 mJ/cm2 resulted in 90% inactivation at wavelengths of 255 and 265 nm. Exposure of viruses to longer UV wavelengths, such as 275 and 285 nm, required much higher doses (up to 120 mJ/cm2) for inactivation. Regarding inactivation, non-enveloped MNV required much higher UV doses for all tested wavelengths compared with SARS-CoV-2 or HIV-1.
Overall, the results support the use of LEDs emitting at shorter wavelengths of the UV-C spectrum to inactivate bacteria as well as enveloped and non-enveloped viruses by exposure to the appropriate UV dose. However, low availability and excessive production costs of shortwave UV-C LEDs restricts implementation at present, and supports the use of longwave UV-C LEDs in combination with higher irradiation doses.</description><identifier>ISSN: 0195-6701</identifier><identifier>ISSN: 1532-2939</identifier><identifier>EISSN: 1532-2939</identifier><identifier>DOI: 10.1016/j.jhin.2022.12.023</identifier><identifier>PMID: 36754288</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Animals ; Anti-Infective Agents ; Bacteria ; COVID-19 ; Disinfection - methods ; Escherichia coli ; Humans ; Inactivation kinetics ; Mice ; Norovirus ; SARS-CoV-2 ; Surfaces ; Ultraviolet Rays ; UV-B ; UV-C ; UV-LED ; Virus Inactivation ; Viruses</subject><ispartof>The Journal of hospital infection, 2023-05, Vol.135, p.11-17</ispartof><rights>2023 The Authors</rights><rights>Copyright © 2023 The Authors. Published by Elsevier Ltd.. All rights reserved.</rights><rights>2023 The Authors 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c456t-584cd18a8ef2aea3f5df84c5d825b17c1056423559d7e155a533fdaae7c458e23</citedby><cites>FETCH-LOGICAL-c456t-584cd18a8ef2aea3f5df84c5d825b17c1056423559d7e155a533fdaae7c458e23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0195670123000361$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36754288$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Schöbel, H.</creatorcontrib><creatorcontrib>Diem, G.</creatorcontrib><creatorcontrib>Kiechl, J.</creatorcontrib><creatorcontrib>Chistè, D.</creatorcontrib><creatorcontrib>Bertacchi, G.</creatorcontrib><creatorcontrib>Mayr, A.</creatorcontrib><creatorcontrib>Wilflingseder, D.</creatorcontrib><creatorcontrib>Lass-Flörl, C.</creatorcontrib><creatorcontrib>Posch, W.</creatorcontrib><title>Antimicrobial efficacy and inactivation kinetics of a novel LED-based UV-irradiation technology</title><title>The Journal of hospital infection</title><addtitle>J Hosp Infect</addtitle><description>Ultraviolet (UV)-light-emitting diodes (UV-LEDs) are energy efficient and of special interest for the inactivation of micro-organisms. In the context of the coronavirus disease 2019 pandemic, novel UV technologies can offer a powerful alternative for effective infection prevention and control.
This study assessed the antimicrobial efficacy of UV-C LEDs on Escherichia coli, Pseudomonas fluorescens and Listeria innocua, as well as severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), human immunodeficiency virus-1 (HIV-1) and murine norovirus (MNV), dried on inanimate surfaces, based on European Standard EN 17272.
This study found 90% inactivation rates for the tested bacteria at mean UV-C doses, averaged over all three investigated UV-C wavelengths, of 1.7 mJ/cm2 for E. coli, 1.9 mJ/cm2 for P. fluorescens and 1.5 mJ/cm2 for L. innocua. For the tested viruses, UV doses <15 mJ/cm2 resulted in 90% inactivation at wavelengths of 255 and 265 nm. Exposure of viruses to longer UV wavelengths, such as 275 and 285 nm, required much higher doses (up to 120 mJ/cm2) for inactivation. Regarding inactivation, non-enveloped MNV required much higher UV doses for all tested wavelengths compared with SARS-CoV-2 or HIV-1.
Overall, the results support the use of LEDs emitting at shorter wavelengths of the UV-C spectrum to inactivate bacteria as well as enveloped and non-enveloped viruses by exposure to the appropriate UV dose. However, low availability and excessive production costs of shortwave UV-C LEDs restricts implementation at present, and supports the use of longwave UV-C LEDs in combination with higher irradiation doses.</description><subject>Animals</subject><subject>Anti-Infective Agents</subject><subject>Bacteria</subject><subject>COVID-19</subject><subject>Disinfection - methods</subject><subject>Escherichia coli</subject><subject>Humans</subject><subject>Inactivation kinetics</subject><subject>Mice</subject><subject>Norovirus</subject><subject>SARS-CoV-2</subject><subject>Surfaces</subject><subject>Ultraviolet Rays</subject><subject>UV-B</subject><subject>UV-C</subject><subject>UV-LED</subject><subject>Virus Inactivation</subject><subject>Viruses</subject><issn>0195-6701</issn><issn>1532-2939</issn><issn>1532-2939</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kcFuEzEQhi0EomnhBTigPXLZxfaud70SEqpKC0iRuLS9WhN73EzY2MXeRMrb4yilggsnS-Pv_23Nx9g7wRvBRf9x02zWFBrJpWyEbLhsX7CFUK2s5diOL9mCi1HV_cDFGTvPecM5L3P1mp21_aA6qfWCmcsw05ZsiiuCqULvyYI9VBBcRQHsTHuYKYbqJwWcyeYq-gqqEPc4VcvrL_UKMrrq7r6mlMDRCZ7RrkOc4sPhDXvlYcr49um8YHc317dX3-rlj6_fry6Xte1UP9dKd9YJDRq9BITWK-fLSDkt1UoMVnDVd7JVanQDCqVAta13ADiUvEbZXrDPp97H3WqLzmKYE0zmMdEW0sFEIPPvTaC1eYh7IzjvhNZDafjw1JDirx3m2WwpW5wmCBh32chh6PTYq14UVJ7QsracE_rndwQ3RzVmY45qzFGNEdIUNSX0_u8fPkf-uCjApxOAZU97wmSyJQwWHSW0s3GR_tf_G7RBoeE</recordid><startdate>20230501</startdate><enddate>20230501</enddate><creator>Schöbel, H.</creator><creator>Diem, G.</creator><creator>Kiechl, J.</creator><creator>Chistè, D.</creator><creator>Bertacchi, G.</creator><creator>Mayr, A.</creator><creator>Wilflingseder, D.</creator><creator>Lass-Flörl, C.</creator><creator>Posch, W.</creator><general>Elsevier Ltd</general><general>The Authors. Published by Elsevier Ltd on behalf of The Healthcare Infection Society</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20230501</creationdate><title>Antimicrobial efficacy and inactivation kinetics of a novel LED-based UV-irradiation technology</title><author>Schöbel, H. ; Diem, G. ; Kiechl, J. ; Chistè, D. ; Bertacchi, G. ; Mayr, A. ; Wilflingseder, D. ; Lass-Flörl, C. ; Posch, W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c456t-584cd18a8ef2aea3f5df84c5d825b17c1056423559d7e155a533fdaae7c458e23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Animals</topic><topic>Anti-Infective Agents</topic><topic>Bacteria</topic><topic>COVID-19</topic><topic>Disinfection - methods</topic><topic>Escherichia coli</topic><topic>Humans</topic><topic>Inactivation kinetics</topic><topic>Mice</topic><topic>Norovirus</topic><topic>SARS-CoV-2</topic><topic>Surfaces</topic><topic>Ultraviolet Rays</topic><topic>UV-B</topic><topic>UV-C</topic><topic>UV-LED</topic><topic>Virus Inactivation</topic><topic>Viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schöbel, H.</creatorcontrib><creatorcontrib>Diem, G.</creatorcontrib><creatorcontrib>Kiechl, J.</creatorcontrib><creatorcontrib>Chistè, D.</creatorcontrib><creatorcontrib>Bertacchi, G.</creatorcontrib><creatorcontrib>Mayr, A.</creatorcontrib><creatorcontrib>Wilflingseder, D.</creatorcontrib><creatorcontrib>Lass-Flörl, C.</creatorcontrib><creatorcontrib>Posch, W.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Journal of hospital infection</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schöbel, H.</au><au>Diem, G.</au><au>Kiechl, J.</au><au>Chistè, D.</au><au>Bertacchi, G.</au><au>Mayr, A.</au><au>Wilflingseder, D.</au><au>Lass-Flörl, C.</au><au>Posch, W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antimicrobial efficacy and inactivation kinetics of a novel LED-based UV-irradiation technology</atitle><jtitle>The Journal of hospital infection</jtitle><addtitle>J Hosp Infect</addtitle><date>2023-05-01</date><risdate>2023</risdate><volume>135</volume><spage>11</spage><epage>17</epage><pages>11-17</pages><issn>0195-6701</issn><issn>1532-2939</issn><eissn>1532-2939</eissn><abstract>Ultraviolet (UV)-light-emitting diodes (UV-LEDs) are energy efficient and of special interest for the inactivation of micro-organisms. In the context of the coronavirus disease 2019 pandemic, novel UV technologies can offer a powerful alternative for effective infection prevention and control.
This study assessed the antimicrobial efficacy of UV-C LEDs on Escherichia coli, Pseudomonas fluorescens and Listeria innocua, as well as severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), human immunodeficiency virus-1 (HIV-1) and murine norovirus (MNV), dried on inanimate surfaces, based on European Standard EN 17272.
This study found 90% inactivation rates for the tested bacteria at mean UV-C doses, averaged over all three investigated UV-C wavelengths, of 1.7 mJ/cm2 for E. coli, 1.9 mJ/cm2 for P. fluorescens and 1.5 mJ/cm2 for L. innocua. For the tested viruses, UV doses <15 mJ/cm2 resulted in 90% inactivation at wavelengths of 255 and 265 nm. Exposure of viruses to longer UV wavelengths, such as 275 and 285 nm, required much higher doses (up to 120 mJ/cm2) for inactivation. Regarding inactivation, non-enveloped MNV required much higher UV doses for all tested wavelengths compared with SARS-CoV-2 or HIV-1.
Overall, the results support the use of LEDs emitting at shorter wavelengths of the UV-C spectrum to inactivate bacteria as well as enveloped and non-enveloped viruses by exposure to the appropriate UV dose. However, low availability and excessive production costs of shortwave UV-C LEDs restricts implementation at present, and supports the use of longwave UV-C LEDs in combination with higher irradiation doses.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>36754288</pmid><doi>10.1016/j.jhin.2022.12.023</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0195-6701 |
| ispartof | The Journal of hospital infection, 2023-05, Vol.135, p.11-17 |
| issn | 0195-6701 1532-2939 1532-2939 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10041887 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals Anti-Infective Agents Bacteria COVID-19 Disinfection - methods Escherichia coli Humans Inactivation kinetics Mice Norovirus SARS-CoV-2 Surfaces Ultraviolet Rays UV-B UV-C UV-LED Virus Inactivation Viruses |
| title | Antimicrobial efficacy and inactivation kinetics of a novel LED-based UV-irradiation technology |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-14T05%3A23%3A55IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Antimicrobial%20efficacy%20and%20inactivation%20kinetics%20of%20a%20novel%20LED-based%20UV-irradiation%20technology&rft.jtitle=The%20Journal%20of%20hospital%20infection&rft.au=Sch%C3%B6bel,%20H.&rft.date=2023-05-01&rft.volume=135&rft.spage=11&rft.epage=17&rft.pages=11-17&rft.issn=0195-6701&rft.eissn=1532-2939&rft_id=info:doi/10.1016/j.jhin.2022.12.023&rft_dat=%3Cproquest_pubme%3E2774896561%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2774896561&rft_id=info:pmid/36754288&rft_els_id=S0195670123000361&rfr_iscdi=true |