Re-assigning the histologic identities of COV434 and TOV-112D ovarian cancer cell lines

The development of effective cancer treatments depends on the availability of cell lines that faithfully recapitulate the cancer in question. This study definitively re-assigns the histologic identities of two ovarian cancer cell lines, COV434 (originally described as a granulosa cell tumour) and TO...

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Veröffentlicht in:	Gynecologic oncology 2021-02, Vol.160 (2), p.568-578
Hauptverfasser:	Karnezis, Anthony N., Chen, Shary Yuting, Chow, Christine, Yang, Winnie, Hendricks, William P.D., Ramos, Pilar, Briones, Natalia, Mes-Masson, Anne-Marie, Bosse, Tjalling, Gilks, C. Blake, Trent, Jeffrey M., Weissman, Bernard, Huntsman, David G., Wang, Yemin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Carcinoma, Ovarian Epithelial - diagnosis Carcinoma, Ovarian Epithelial - drug therapy Carcinoma, Ovarian Epithelial - genetics Carcinoma, Ovarian Epithelial - pathology Carcinoma, Small Cell - diagnosis Carcinoma, Small Cell - drug therapy Carcinoma, Small Cell - genetics Carcinoma, Small Cell - pathology Cell Dedifferentiation - genetics Cell Line, Tumor - drug effects Cell Line, Tumor - pathology COV434 Dedifferentiated carcinoma DNA Helicases - analysis DNA Helicases - deficiency DNA Helicases - genetics Enhancer of Zeste Homolog 2 Protein - antagonists & inhibitors Exome Sequencing Female Gene Expression Profiling Granulosa cell tumour Humans Mice Nuclear Proteins - analysis Nuclear Proteins - deficiency Nuclear Proteins - genetics Ovarian Neoplasms - diagnosis Ovarian Neoplasms - drug therapy Ovarian Neoplasms - genetics Ovarian Neoplasms - pathology SCCOHT SMARCA4 TOV-112D Transcription Factors - analysis Transcription Factors - deficiency Transcription Factors - genetics Xenograft Model Antitumor Assays
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