Lower extremity Interlimb coordination associated brain activity in young female athletes: A biomechanically instrumented neuroimaging study
Bilateral sensorimotor coordination is required for everyday activities, such as walking and sitting down/standing up from a chair. Sensorimotor coordination functional neuroimaging (fMRI) paradigms (e.g., stepping, cycling) increase activity in the sensorimotor cortex, supplementary motor area, ins...
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| Veröffentlicht in: | Psychophysiology 2023-04, Vol.60 (4), p.e14221-n/a |
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| creator | Slutsky‐Ganesh, Alexis B. Anand, Manish Diekfuss, Jed A. Myer, Gregory D. Grooms, Dustin R. |
| description | Bilateral sensorimotor coordination is required for everyday activities, such as walking and sitting down/standing up from a chair. Sensorimotor coordination functional neuroimaging (fMRI) paradigms (e.g., stepping, cycling) increase activity in the sensorimotor cortex, supplementary motor area, insula, and cerebellum. Although these paradigms are designed to assay coordination, performance measures are rarely collected simultaneously with fMRI. Therefore, we aimed to identify neural correlates of lower extremity coordination using a bilateral, in‐phase, multi‐joint coordination task with concurrent MRI‐compatible 3D motion analysis. Seventeen female athletes (15.0 ± 1.4 years) completed a bilateral, multi‐joint lower‐extremity coordination task during brain fMRI. Interlimb coordination was quantified from kinematic data as the correlation between peak‐to‐peak knee flexion cycle time between legs. Standard preprocessing and whole‐brain analyses for task‐based fMRI were completed in FSL, controlling for total movement cycles and neuroanatomical differences, with interlimb coordination as a covariate of interest. A clusterwise multi‐comparison correction was applied at z > 3.1 and p |
| doi_str_mv | 10.1111/psyp.14221 |
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In the first report of a bilateral lower extremity, in‐phase, multi‐joint coordination fMRI motor paradigm with concurrent kinematics, we found that lower extremity coordination was negatively associated with neural activity in the posterior cingulate gyrus, precuneus, and lateral occipital cortex; such that poorer coordination is associated with greater activity. This alteration may indicate a failed compensatory strategy to maintain motor control or higher central demand downstream from reduced afferent acuity.</description><identifier>ISSN: 0048-5772</identifier><identifier>EISSN: 1469-8986</identifier><identifier>EISSN: 1540-5958</identifier><identifier>DOI: 10.1111/psyp.14221</identifier><identifier>PMID: 36416574</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Acuity ; Anatomy ; Attention ; Brain architecture ; Brain mapping ; central nervous system ; Cerebellum ; Cortex (motor) ; Cortex (parietal) ; Female ; fMRI ; Functional magnetic resonance imaging ; human movement ; Humans ; in‐phase ; kinematics ; Leg - physiology ; Lower Extremity - diagnostic imaging ; Medical imaging ; Motor task performance ; Neuroimaging ; Neuroplasticity ; Occipital lobe ; Sensorimotor Cortex ; Sensory neurons ; Somatosensory cortex ; Supplementary motor area ; Walking - physiology</subject><ispartof>Psychophysiology, 2023-04, Vol.60 (4), p.e14221-n/a</ispartof><rights>2022 Society for Psychophysiological Research.</rights><rights>Copyright © 2023 by the Society for Psychophysiological Research</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4131-a52dcb816a3b034a6c75ff1b1e2275b7e334bda63c0fa26876384136a396ec233</citedby><cites>FETCH-LOGICAL-c4131-a52dcb816a3b034a6c75ff1b1e2275b7e334bda63c0fa26876384136a396ec233</cites><orcidid>0000-0001-6102-8224 ; 0000-0001-6905-0266 ; 0000-0003-3835-363X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fpsyp.14221$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fpsyp.14221$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,780,784,885,1416,27923,27924,45573,45574</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36416574$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Slutsky‐Ganesh, Alexis B.</creatorcontrib><creatorcontrib>Anand, Manish</creatorcontrib><creatorcontrib>Diekfuss, Jed A.</creatorcontrib><creatorcontrib>Myer, Gregory D.</creatorcontrib><creatorcontrib>Grooms, Dustin R.</creatorcontrib><title>Lower extremity Interlimb coordination associated brain activity in young female athletes: A biomechanically instrumented neuroimaging study</title><title>Psychophysiology</title><addtitle>Psychophysiology</addtitle><description>Bilateral sensorimotor coordination is required for everyday activities, such as walking and sitting down/standing up from a chair. Sensorimotor coordination functional neuroimaging (fMRI) paradigms (e.g., stepping, cycling) increase activity in the sensorimotor cortex, supplementary motor area, insula, and cerebellum. Although these paradigms are designed to assay coordination, performance measures are rarely collected simultaneously with fMRI. Therefore, we aimed to identify neural correlates of lower extremity coordination using a bilateral, in‐phase, multi‐joint coordination task with concurrent MRI‐compatible 3D motion analysis. Seventeen female athletes (15.0 ± 1.4 years) completed a bilateral, multi‐joint lower‐extremity coordination task during brain fMRI. Interlimb coordination was quantified from kinematic data as the correlation between peak‐to‐peak knee flexion cycle time between legs. Standard preprocessing and whole‐brain analyses for task‐based fMRI were completed in FSL, controlling for total movement cycles and neuroanatomical differences, with interlimb coordination as a covariate of interest. A clusterwise multi‐comparison correction was applied at z > 3.1 and p < .05. Less interlimb coordination during the task was associated with greater activation in the posterior cingulate and precuneus (zmax = 6.41, p < .01) and the lateral occipital cortex (zmax = 7.55, p = .02). The inability to maintain interlimb coordination alongside greater activity in attention‐ and sensory‐related brain regions may indicate a failed compensatory neural strategy to execute the task. Alternatively, greater activity could be secondary to reduced afferent acuity that may be elevating central demand to maintain in‐phase lower extremity motor coordination. Future research aiming to improve sensorimotor coordination should consider interventional approaches uniquely capable of promoting adaptive neuroplasticity to enhance motor control.
In the first report of a bilateral lower extremity, in‐phase, multi‐joint coordination fMRI motor paradigm with concurrent kinematics, we found that lower extremity coordination was negatively associated with neural activity in the posterior cingulate gyrus, precuneus, and lateral occipital cortex; such that poorer coordination is associated with greater activity. This alteration may indicate a failed compensatory strategy to maintain motor control or higher central demand downstream from reduced afferent acuity.</description><subject>Acuity</subject><subject>Anatomy</subject><subject>Attention</subject><subject>Brain architecture</subject><subject>Brain mapping</subject><subject>central nervous system</subject><subject>Cerebellum</subject><subject>Cortex (motor)</subject><subject>Cortex (parietal)</subject><subject>Female</subject><subject>fMRI</subject><subject>Functional magnetic resonance imaging</subject><subject>human movement</subject><subject>Humans</subject><subject>in‐phase</subject><subject>kinematics</subject><subject>Leg - physiology</subject><subject>Lower Extremity - diagnostic imaging</subject><subject>Medical imaging</subject><subject>Motor task performance</subject><subject>Neuroimaging</subject><subject>Neuroplasticity</subject><subject>Occipital lobe</subject><subject>Sensorimotor Cortex</subject><subject>Sensory neurons</subject><subject>Somatosensory cortex</subject><subject>Supplementary motor area</subject><subject>Walking - physiology</subject><issn>0048-5772</issn><issn>1469-8986</issn><issn>1540-5958</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc1qFTEYhoMo9rS68QJkwI0UpubvZDJupBR_CgcsqAtXIZP55pyUTHJMMq1zD160GU8t6sJsEpLne3jDi9Azgs9IWa_2ad6fEU4peYBWhIu2lq0UD9EKYy7rddPQI3Sc0jXGuCWUPkZHTHAi1g1foR-bcAuxgu85wmjzXF36DNHZsatMCLG3XmcbfKVTCsbqDH3VRW3Lhcn2Zhko5zlMflsNMGoHlc47BxnS6-q86mwYwey0t0Y7t7Apx2kEv3g8TDHYUW9tGU556ucn6NGgXYKnd_sJ-vLu7eeLD_Xm4_vLi_NNbThhpNZr2ptOEqFZhxnXwjTrYSAdAUqbddcAY7zrtWAGD5oK2Qgmy2DBWwGGMnaC3hy8-6kboTclT9RO7WNJE2cVtFV_v3i7U9twowjGTMqGFMPLO0MM3yZIWY02GXBOewhTUrRhLWeEs7agL_5Br8MUfflfodpSEZYSF-r0QJkYUoow3KchWC0tq6Vl9avlAj__M_89-rvWApADcGsdzP9RqatPX68O0p_Lh7by</recordid><startdate>202304</startdate><enddate>202304</enddate><creator>Slutsky‐Ganesh, Alexis B.</creator><creator>Anand, Manish</creator><creator>Diekfuss, Jed A.</creator><creator>Myer, Gregory D.</creator><creator>Grooms, Dustin R.</creator><general>Blackwell Publishing Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>K9.</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-6102-8224</orcidid><orcidid>https://orcid.org/0000-0001-6905-0266</orcidid><orcidid>https://orcid.org/0000-0003-3835-363X</orcidid></search><sort><creationdate>202304</creationdate><title>Lower extremity Interlimb coordination associated brain activity in young female athletes: A biomechanically instrumented neuroimaging study</title><author>Slutsky‐Ganesh, Alexis B. ; Anand, Manish ; Diekfuss, Jed A. ; Myer, Gregory D. ; Grooms, Dustin R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4131-a52dcb816a3b034a6c75ff1b1e2275b7e334bda63c0fa26876384136a396ec233</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Acuity</topic><topic>Anatomy</topic><topic>Attention</topic><topic>Brain architecture</topic><topic>Brain mapping</topic><topic>central nervous system</topic><topic>Cerebellum</topic><topic>Cortex (motor)</topic><topic>Cortex (parietal)</topic><topic>Female</topic><topic>fMRI</topic><topic>Functional magnetic resonance imaging</topic><topic>human movement</topic><topic>Humans</topic><topic>in‐phase</topic><topic>kinematics</topic><topic>Leg - physiology</topic><topic>Lower Extremity - diagnostic imaging</topic><topic>Medical imaging</topic><topic>Motor task performance</topic><topic>Neuroimaging</topic><topic>Neuroplasticity</topic><topic>Occipital lobe</topic><topic>Sensorimotor Cortex</topic><topic>Sensory neurons</topic><topic>Somatosensory cortex</topic><topic>Supplementary motor area</topic><topic>Walking - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Slutsky‐Ganesh, Alexis B.</creatorcontrib><creatorcontrib>Anand, Manish</creatorcontrib><creatorcontrib>Diekfuss, Jed A.</creatorcontrib><creatorcontrib>Myer, Gregory D.</creatorcontrib><creatorcontrib>Grooms, Dustin R.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Psychophysiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Slutsky‐Ganesh, Alexis B.</au><au>Anand, Manish</au><au>Diekfuss, Jed A.</au><au>Myer, Gregory D.</au><au>Grooms, Dustin R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lower extremity Interlimb coordination associated brain activity in young female athletes: A biomechanically instrumented neuroimaging study</atitle><jtitle>Psychophysiology</jtitle><addtitle>Psychophysiology</addtitle><date>2023-04</date><risdate>2023</risdate><volume>60</volume><issue>4</issue><spage>e14221</spage><epage>n/a</epage><pages>e14221-n/a</pages><issn>0048-5772</issn><eissn>1469-8986</eissn><eissn>1540-5958</eissn><abstract>Bilateral sensorimotor coordination is required for everyday activities, such as walking and sitting down/standing up from a chair. Sensorimotor coordination functional neuroimaging (fMRI) paradigms (e.g., stepping, cycling) increase activity in the sensorimotor cortex, supplementary motor area, insula, and cerebellum. Although these paradigms are designed to assay coordination, performance measures are rarely collected simultaneously with fMRI. Therefore, we aimed to identify neural correlates of lower extremity coordination using a bilateral, in‐phase, multi‐joint coordination task with concurrent MRI‐compatible 3D motion analysis. Seventeen female athletes (15.0 ± 1.4 years) completed a bilateral, multi‐joint lower‐extremity coordination task during brain fMRI. Interlimb coordination was quantified from kinematic data as the correlation between peak‐to‐peak knee flexion cycle time between legs. Standard preprocessing and whole‐brain analyses for task‐based fMRI were completed in FSL, controlling for total movement cycles and neuroanatomical differences, with interlimb coordination as a covariate of interest. A clusterwise multi‐comparison correction was applied at z > 3.1 and p < .05. Less interlimb coordination during the task was associated with greater activation in the posterior cingulate and precuneus (zmax = 6.41, p < .01) and the lateral occipital cortex (zmax = 7.55, p = .02). The inability to maintain interlimb coordination alongside greater activity in attention‐ and sensory‐related brain regions may indicate a failed compensatory neural strategy to execute the task. Alternatively, greater activity could be secondary to reduced afferent acuity that may be elevating central demand to maintain in‐phase lower extremity motor coordination. Future research aiming to improve sensorimotor coordination should consider interventional approaches uniquely capable of promoting adaptive neuroplasticity to enhance motor control.
In the first report of a bilateral lower extremity, in‐phase, multi‐joint coordination fMRI motor paradigm with concurrent kinematics, we found that lower extremity coordination was negatively associated with neural activity in the posterior cingulate gyrus, precuneus, and lateral occipital cortex; such that poorer coordination is associated with greater activity. This alteration may indicate a failed compensatory strategy to maintain motor control or higher central demand downstream from reduced afferent acuity.</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>36416574</pmid><doi>10.1111/psyp.14221</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0001-6102-8224</orcidid><orcidid>https://orcid.org/0000-0001-6905-0266</orcidid><orcidid>https://orcid.org/0000-0003-3835-363X</orcidid></addata></record> |
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| subjects | Acuity Anatomy Attention Brain architecture Brain mapping central nervous system Cerebellum Cortex (motor) Cortex (parietal) Female fMRI Functional magnetic resonance imaging human movement Humans in‐phase kinematics Leg - physiology Lower Extremity - diagnostic imaging Medical imaging Motor task performance Neuroimaging Neuroplasticity Occipital lobe Sensorimotor Cortex Sensory neurons Somatosensory cortex Supplementary motor area Walking - physiology |
| title | Lower extremity Interlimb coordination associated brain activity in young female athletes: A biomechanically instrumented neuroimaging study |
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