Role of Magnetic Resonance Imaging in Morphometric Alterations of Corpus Callosum in Stroke Patients
Corpus callosum plays a role in interhemispheric integration, language, intelligence, and creativity of individuals, hence variations in corpus callosum size are seen in various neurological diseases such as Alzheimer's and bipolar affective disorder. While the dimensions differ based on gender...
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| Veröffentlicht in: | Curēus (Palo Alto, CA) CA), 2023-02, Vol.15 (2), p.e35332-e35332 |
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| creator | Reddy, Buchipudi Sandeep Naik, Deepti Sakalecha, Anil K L, Yashas Ullas Uhasai, Kalathuru Mannan V, Jayendra |
| description | Corpus callosum plays a role in interhemispheric integration, language, intelligence, and creativity of individuals, hence variations in corpus callosum size are seen in various neurological diseases such as Alzheimer's and bipolar affective disorder. While the dimensions differ based on gender, age, and ethnicity, pathological variations are seen with some diseases such as vascular dementia, leukoaraiosis, stroke, and carotid artery stenosis. This study was conducted to compare the morphometric alterations of the corpus callosum between normal subjects and stroke patients using magnetic resonance imaging (MRI).
This was a case-control study conducted on 84 subjects divided into cases and control groups. The widths of the genu, body & splenium, and anterior-posterior (AP) diameter of the corpus callosum were measured and the values were compared among the two groups. Student's t-test and regression analysis were utilized for the analysis of data and p60 years. There was no discrepancy between cases and controls or between the age groups. The mean width of genu, body & splenium, and AP diameter was compared between normal individuals and stroke patients. It was noted to be significantly lesser in cases than in controls. The morphometric indices i.e., width of genu, body & splenium, and AP diameter of the corpus callosum in cases versus controls were noted to be 9.8 ± 1.2 vs. 10.27 ± 0.3 mm, p=0.12; 5.1±0.9 vs. 5.3±0.24 mm, p=0.25; 12.11 ± 9.65 vs. 12.52 ± 13.9 mm, p=0.04 (significant) and 71.22±3.1 vs. 72.32±1.2, p=0.23, respectively.
This study showed that patients with stroke have a significant reduction in morphometric indices i.e., width of genu, body & splenium, and the AP diameter of the corpus callosum when compared to normal individuals. |
| doi_str_mv | 10.7759/cureus.35332 |
| format | Article |
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This was a case-control study conducted on 84 subjects divided into cases and control groups. The widths of the genu, body & splenium, and anterior-posterior (AP) diameter of the corpus callosum were measured and the values were compared among the two groups. Student's t-test and regression analysis were utilized for the analysis of data and p<0.05 was considered statistically significant.
Sixteen patients (19.04%) belonged to the age range of 18-40 years, 32 (38.09%) belonged to the age range of 41-60 years and 36 (42.8%) belonged to the age group of >60 years. There was no discrepancy between cases and controls or between the age groups. The mean width of genu, body & splenium, and AP diameter was compared between normal individuals and stroke patients. It was noted to be significantly lesser in cases than in controls. The morphometric indices i.e., width of genu, body & splenium, and AP diameter of the corpus callosum in cases versus controls were noted to be 9.8 ± 1.2 vs. 10.27 ± 0.3 mm, p=0.12; 5.1±0.9 vs. 5.3±0.24 mm, p=0.25; 12.11 ± 9.65 vs. 12.52 ± 13.9 mm, p=0.04 (significant) and 71.22±3.1 vs. 72.32±1.2, p=0.23, respectively.
This study showed that patients with stroke have a significant reduction in morphometric indices i.e., width of genu, body & splenium, and the AP diameter of the corpus callosum when compared to normal individuals.</description><identifier>ISSN: 2168-8184</identifier><identifier>EISSN: 2168-8184</identifier><identifier>DOI: 10.7759/cureus.35332</identifier><identifier>PMID: 36974258</identifier><language>eng</language><publisher>United States: Cureus Inc</publisher><subject>Age groups ; Alzheimer's disease ; Anatomy ; Brain research ; Dementia ; Gender ; Higher education ; Internal Medicine ; Magnetic resonance imaging ; Radiology ; Stroke</subject><ispartof>Curēus (Palo Alto, CA), 2023-02, Vol.15 (2), p.e35332-e35332</ispartof><rights>Copyright © 2023, Reddy et al.</rights><rights>Copyright © 2023, Reddy et al. This work is published under https://creativecommons.org/licenses/by/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Copyright © 2023, Reddy et al. 2023 Reddy et al.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c343t-daa0af5504b623abe7d7926069e982a7ef433d427cb4dd3164587b279304493a3</citedby><cites>FETCH-LOGICAL-c343t-daa0af5504b623abe7d7926069e982a7ef433d427cb4dd3164587b279304493a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10038770/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10038770/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,886,27928,27929,53795,53797</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36974258$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Reddy, Buchipudi Sandeep</creatorcontrib><creatorcontrib>Naik, Deepti</creatorcontrib><creatorcontrib>Sakalecha, Anil K</creatorcontrib><creatorcontrib>L, Yashas Ullas</creatorcontrib><creatorcontrib>Uhasai, Kalathuru</creatorcontrib><creatorcontrib>Mannan V, Jayendra</creatorcontrib><title>Role of Magnetic Resonance Imaging in Morphometric Alterations of Corpus Callosum in Stroke Patients</title><title>Curēus (Palo Alto, CA)</title><addtitle>Cureus</addtitle><description>Corpus callosum plays a role in interhemispheric integration, language, intelligence, and creativity of individuals, hence variations in corpus callosum size are seen in various neurological diseases such as Alzheimer's and bipolar affective disorder. While the dimensions differ based on gender, age, and ethnicity, pathological variations are seen with some diseases such as vascular dementia, leukoaraiosis, stroke, and carotid artery stenosis. This study was conducted to compare the morphometric alterations of the corpus callosum between normal subjects and stroke patients using magnetic resonance imaging (MRI).
This was a case-control study conducted on 84 subjects divided into cases and control groups. The widths of the genu, body & splenium, and anterior-posterior (AP) diameter of the corpus callosum were measured and the values were compared among the two groups. Student's t-test and regression analysis were utilized for the analysis of data and p<0.05 was considered statistically significant.
Sixteen patients (19.04%) belonged to the age range of 18-40 years, 32 (38.09%) belonged to the age range of 41-60 years and 36 (42.8%) belonged to the age group of >60 years. There was no discrepancy between cases and controls or between the age groups. The mean width of genu, body & splenium, and AP diameter was compared between normal individuals and stroke patients. It was noted to be significantly lesser in cases than in controls. The morphometric indices i.e., width of genu, body & splenium, and AP diameter of the corpus callosum in cases versus controls were noted to be 9.8 ± 1.2 vs. 10.27 ± 0.3 mm, p=0.12; 5.1±0.9 vs. 5.3±0.24 mm, p=0.25; 12.11 ± 9.65 vs. 12.52 ± 13.9 mm, p=0.04 (significant) and 71.22±3.1 vs. 72.32±1.2, p=0.23, respectively.
This study showed that patients with stroke have a significant reduction in morphometric indices i.e., width of genu, body & splenium, and the AP diameter of the corpus callosum when compared to normal individuals.</description><subject>Age groups</subject><subject>Alzheimer's disease</subject><subject>Anatomy</subject><subject>Brain research</subject><subject>Dementia</subject><subject>Gender</subject><subject>Higher education</subject><subject>Internal Medicine</subject><subject>Magnetic resonance imaging</subject><subject>Radiology</subject><subject>Stroke</subject><issn>2168-8184</issn><issn>2168-8184</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNpd0c9P2zAUB3ALMVHEeuOMIu3CYQXbz47j04Sq_UAqAnXjbDnJSxtI7GInSPz3c9cOASdbeh-_56cvIaeMXigl9WU1BhzjBUgAfkCOOcuLWcEKcfjmPiHTGB8opYwqThU9IhPItRJcFsekXvoOM99kN3blcGirbInRO-sqzK57u2rdKmtdduPDZu17HEISV92AwQ6td3H7cp5qY8zmtut8HPst_z0E_4jZXULohviZfGpsF3G6P0_I_Y_vf-a_Zovbn9fzq8WsAgHDrLaW2kZKKsqcgy1R1UrznOYadcGtwkYA1IKrqhR1DSwXslAlVxqoEBosnJBvu76bseyxrtLsYDuzCW1vw4vxtjXvK65dm5V_NoxSKJSiqcP5vkPwTyPGwfRtrLDrrEM_RpOGcUml1CzRLx_ogx-DS_ttFQDTXEFSX3eqCj7GgM3rbxg12wjNLkLzL8LEz95u8Ir_BwZ_AcBDmMA</recordid><startdate>20230222</startdate><enddate>20230222</enddate><creator>Reddy, Buchipudi Sandeep</creator><creator>Naik, Deepti</creator><creator>Sakalecha, Anil K</creator><creator>L, Yashas Ullas</creator><creator>Uhasai, Kalathuru</creator><creator>Mannan V, Jayendra</creator><general>Cureus Inc</general><general>Cureus</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20230222</creationdate><title>Role of Magnetic Resonance Imaging in Morphometric Alterations of Corpus Callosum in Stroke Patients</title><author>Reddy, Buchipudi Sandeep ; Naik, Deepti ; Sakalecha, Anil K ; L, Yashas Ullas ; Uhasai, Kalathuru ; Mannan V, Jayendra</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c343t-daa0af5504b623abe7d7926069e982a7ef433d427cb4dd3164587b279304493a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Age groups</topic><topic>Alzheimer's disease</topic><topic>Anatomy</topic><topic>Brain research</topic><topic>Dementia</topic><topic>Gender</topic><topic>Higher education</topic><topic>Internal Medicine</topic><topic>Magnetic resonance imaging</topic><topic>Radiology</topic><topic>Stroke</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Reddy, Buchipudi Sandeep</creatorcontrib><creatorcontrib>Naik, Deepti</creatorcontrib><creatorcontrib>Sakalecha, Anil K</creatorcontrib><creatorcontrib>L, Yashas Ullas</creatorcontrib><creatorcontrib>Uhasai, Kalathuru</creatorcontrib><creatorcontrib>Mannan V, Jayendra</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Curēus (Palo Alto, CA)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Reddy, Buchipudi Sandeep</au><au>Naik, Deepti</au><au>Sakalecha, Anil K</au><au>L, Yashas Ullas</au><au>Uhasai, Kalathuru</au><au>Mannan V, Jayendra</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Role of Magnetic Resonance Imaging in Morphometric Alterations of Corpus Callosum in Stroke Patients</atitle><jtitle>Curēus (Palo Alto, CA)</jtitle><addtitle>Cureus</addtitle><date>2023-02-22</date><risdate>2023</risdate><volume>15</volume><issue>2</issue><spage>e35332</spage><epage>e35332</epage><pages>e35332-e35332</pages><issn>2168-8184</issn><eissn>2168-8184</eissn><abstract>Corpus callosum plays a role in interhemispheric integration, language, intelligence, and creativity of individuals, hence variations in corpus callosum size are seen in various neurological diseases such as Alzheimer's and bipolar affective disorder. While the dimensions differ based on gender, age, and ethnicity, pathological variations are seen with some diseases such as vascular dementia, leukoaraiosis, stroke, and carotid artery stenosis. This study was conducted to compare the morphometric alterations of the corpus callosum between normal subjects and stroke patients using magnetic resonance imaging (MRI).
This was a case-control study conducted on 84 subjects divided into cases and control groups. The widths of the genu, body & splenium, and anterior-posterior (AP) diameter of the corpus callosum were measured and the values were compared among the two groups. Student's t-test and regression analysis were utilized for the analysis of data and p<0.05 was considered statistically significant.
Sixteen patients (19.04%) belonged to the age range of 18-40 years, 32 (38.09%) belonged to the age range of 41-60 years and 36 (42.8%) belonged to the age group of >60 years. There was no discrepancy between cases and controls or between the age groups. The mean width of genu, body & splenium, and AP diameter was compared between normal individuals and stroke patients. It was noted to be significantly lesser in cases than in controls. The morphometric indices i.e., width of genu, body & splenium, and AP diameter of the corpus callosum in cases versus controls were noted to be 9.8 ± 1.2 vs. 10.27 ± 0.3 mm, p=0.12; 5.1±0.9 vs. 5.3±0.24 mm, p=0.25; 12.11 ± 9.65 vs. 12.52 ± 13.9 mm, p=0.04 (significant) and 71.22±3.1 vs. 72.32±1.2, p=0.23, respectively.
This study showed that patients with stroke have a significant reduction in morphometric indices i.e., width of genu, body & splenium, and the AP diameter of the corpus callosum when compared to normal individuals.</abstract><cop>United States</cop><pub>Cureus Inc</pub><pmid>36974258</pmid><doi>10.7759/cureus.35332</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Age groups Alzheimer's disease Anatomy Brain research Dementia Gender Higher education Internal Medicine Magnetic resonance imaging Radiology Stroke |
| title | Role of Magnetic Resonance Imaging in Morphometric Alterations of Corpus Callosum in Stroke Patients |
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