Pulmonary Arterial Hypertension Patients Have a Proinflammatory Gut Microbiome and Altered Circulating Microbial Metabolites

Inflammation drives pulmonary arterial hypertension (PAH). Gut dysbiosis causes immune dysregulation and systemic inflammation by altering circulating microbial metabolites; however, little is known about gut dysbiosis and microbial metabolites in PAH. To characterize the gut microbiome and microbia...

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Veröffentlicht in:	American journal of respiratory and critical care medicine 2023-03, Vol.207 (6), p.740-756
Hauptverfasser:	Moutsoglou, Daphne M, Tatah, Jasmine, Prisco, Sasha Z, Prins, Kurt W, Staley, Christopher, Lopez, Sharon, Blake, Madelyn, Teigen, Levi, Kazmirczak, Felipe, Weir, E Kenneth, Kabage, Amanda J, Guan, Weihua, Khoruts, Alexander, Thenappan, Thenappan
Format:	Artikel
Sprache:	eng
Schlagworte:	Bile Acids and Salts Digestive system Dysbiosis Familial Primary Pulmonary Hypertension Gastrointestinal Microbiome - genetics Humans Inflammation Metabolites Microbiology Microbiota Original Phylogeny Pulmonary Arterial Hypertension Pulmonary arteries Pulmonary hypertension Vascular Diseases
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