DNA methylation of the promoter region at the CREB1 binding site is a mechanism for the epigenetic regulation of brain-specific PKMζ

Protein kinase M zeta, PKMζ, is a brain enriched kinase with a well characterized role in Long-Term Potentiation (LTP), the activity-dependent strengthening of synapses involved in long-term memory formation. However, little is known about the molecular mechanisms that maintain the tissue specificit...

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Veröffentlicht in:	Biochimica et biophysica acta. Gene regulatory mechanisms 2023-03, Vol.1866 (1), p.194909-194909, Article 194909
Hauptverfasser:	Pramio, Dimitrius Tansini, Vieceli, Felipe Monteleone, Varella-Branco, Elisa, Goes, Carolina Purcell, Kobayashi, Gerson Shigeru, da Silva Pelegrina, Diogo Vieira, de Moraes, Beatriz Caroline, El Allam, Aicha, De Kumar, Bony, Jara, Gabriel, Farfel, José Marcelo, Bennett, David Alan, Kundu, Somanath, Viapiano, Mariano S., Reis, Eduardo Moraes, de Oliveira, Paulo Sergio Lopes, dos Santos e Passos-Bueno, Maria Rita, Rothlin, Carla V., Ghosh, Sourav, Schechtman, Deborah
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease Alzheimer's disease Brain CREB1 Cyclic AMP Response Element-Binding Protein - genetics DNA Methylation Epigenesis, Genetic Epigenetics Humans Long-Term Potentiation - physiology PKMζ
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