Fitness and Functional Landscapes of the E. coli RNase III Gene rnc

Abstract How protein properties such as protein activity and protein essentiality affect the distribution of fitness effects (DFE) of mutations are important questions in protein evolution. Deep mutational scanning studies typically measure the effects of a comprehensive set of mutations on either p...

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Veröffentlicht in:	Molecular biology and evolution 2023-03, Vol.40 (3)
Hauptverfasser:	Weeks, Ryan, Ostermeier, Marc
Format:	Artikel
Sprache:	eng
Schlagworte:	Discoveries Enzymes Escherichia coli Escherichia coli - genetics Escherichia coli - metabolism Escherichia coli Proteins - genetics Genetic aspects Hydrolases Mutation Physiological aspects Ribonuclease Ribonuclease III - genetics Ribosomal RNA
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