Multiple Myeloma with Hyperammonemia Treated with Novel Agents: A Case Series of Three Patients
Multiple myeloma (MM) is a cancer characterized by the expansion of plasma cells in the bone marrow. Survival times of patients with MM have increased due to the development of novel therapeutic agents. We herein highlight three MM cases that had a poor prognosis despite treatment with novel therape...
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| Veröffentlicht in: | Internal Medicine 2023/03/01, Vol.62(5), pp.775-778 |
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| container_title | Internal Medicine |
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| creator | Nakamura, Hajime Takada, Kohichi Murase, Kazuyuki Ikeda, Hiroshi Iyama, Satoshi Manabe, Tatsuo Kobune, Masayoshi |
| description | Multiple myeloma (MM) is a cancer characterized by the expansion of plasma cells in the bone marrow. Survival times of patients with MM have increased due to the development of novel therapeutic agents. We herein highlight three MM cases that had a poor prognosis despite treatment with novel therapeutic agents. Of note, all patients presented with hyperammonemia that led to a consciousness disorder. The outcome for patients with MM showing high levels of serum ammonia continues to be poor, even with the use of novel therapies. For such patients showing a consciousness disorder, hyperammonemia should be considered as a possible cause. |
| doi_str_mv | 10.2169/internalmedicine.0010-22 |
| format | Article |
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Med.</addtitle><description>Multiple myeloma (MM) is a cancer characterized by the expansion of plasma cells in the bone marrow. Survival times of patients with MM have increased due to the development of novel therapeutic agents. We herein highlight three MM cases that had a poor prognosis despite treatment with novel therapeutic agents. Of note, all patients presented with hyperammonemia that led to a consciousness disorder. The outcome for patients with MM showing high levels of serum ammonia continues to be poor, even with the use of novel therapies. For such patients showing a consciousness disorder, hyperammonemia should be considered as a possible cause.</description><subject>Ammonia</subject><subject>Case Report</subject><subject>Consciousness</subject><subject>Consciousness Disorders</subject><subject>Humans</subject><subject>Hyperammonemia</subject><subject>Hyperammonemia - etiology</subject><subject>Internal medicine</subject><subject>Multiple myeloma</subject><subject>Multiple Myeloma - complications</subject><subject>Plasma cells</subject><issn>0918-2918</issn><issn>1349-7235</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNplkV-LEzEUxYMobq1-BQn44sus-TeTiS9SirrC7ipYn0MmvdOmZCY1SVf67c3QWnR9OSHc3703OQchTMk1o41658YMcTR-gLWzboRrQiipGHuCZpQLVUnG66doRhRtK1bkCr1IaUcIb6Viz9EVr1tJa6lmSN8dfHZ7D_juCD4MBv9yeYtvjnuIZhjCCIMzeBXBZFifavfhATxebGDM6T1e4KVJgL9DdJBw6PFqGwHwN5PdBLxEz3rjE7w6n3P049PH1fKmuv36-ctycVvZhpJcKSmsEaZZEybquhdENlw20naqk721wpYrcGhNJxQlgitpuBKsUyBh3fUtn6MPp7n7Q1dcsWV3NF7voxtMPOpgnP63Mrqt3oQHTYsrkhSZo7fnCTH8PEDKenDJgvdmhHBImjVKCCqLgwV98wjdhcOUR6Fk20hGisGFak-UjSGlCP3lNZToKUb9OEY9xagZK62v__7NpfFPbgW4PwG7lM0GLoCJ2VkP_09umK4nOW-4gHZrooaR_wblrrvT</recordid><startdate>20230301</startdate><enddate>20230301</enddate><creator>Nakamura, Hajime</creator><creator>Takada, Kohichi</creator><creator>Murase, Kazuyuki</creator><creator>Ikeda, Hiroshi</creator><creator>Iyama, Satoshi</creator><creator>Manabe, Tatsuo</creator><creator>Kobune, Masayoshi</creator><general>The Japanese Society of Internal Medicine</general><general>Japan Science and Technology Agency</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20230301</creationdate><title>Multiple Myeloma with Hyperammonemia Treated with Novel Agents: A Case Series of Three Patients</title><author>Nakamura, Hajime ; Takada, Kohichi ; Murase, Kazuyuki ; Ikeda, Hiroshi ; Iyama, Satoshi ; Manabe, Tatsuo ; Kobune, Masayoshi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c610t-974ca4a6d02455f40763767cb9b7fcc4c637e3e8ab49104397a3942b9e7edbf83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Ammonia</topic><topic>Case Report</topic><topic>Consciousness</topic><topic>Consciousness Disorders</topic><topic>Humans</topic><topic>Hyperammonemia</topic><topic>Hyperammonemia - etiology</topic><topic>Internal medicine</topic><topic>Multiple myeloma</topic><topic>Multiple Myeloma - complications</topic><topic>Plasma cells</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nakamura, Hajime</creatorcontrib><creatorcontrib>Takada, Kohichi</creatorcontrib><creatorcontrib>Murase, Kazuyuki</creatorcontrib><creatorcontrib>Ikeda, Hiroshi</creatorcontrib><creatorcontrib>Iyama, Satoshi</creatorcontrib><creatorcontrib>Manabe, Tatsuo</creatorcontrib><creatorcontrib>Kobune, Masayoshi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Internal Medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nakamura, Hajime</au><au>Takada, Kohichi</au><au>Murase, Kazuyuki</au><au>Ikeda, Hiroshi</au><au>Iyama, Satoshi</au><au>Manabe, Tatsuo</au><au>Kobune, Masayoshi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Multiple Myeloma with Hyperammonemia Treated with Novel Agents: A Case Series of Three Patients</atitle><jtitle>Internal Medicine</jtitle><addtitle>Intern. Med.</addtitle><date>2023-03-01</date><risdate>2023</risdate><volume>62</volume><issue>5</issue><spage>775</spage><epage>778</epage><pages>775-778</pages><artnum>0010-22</artnum><issn>0918-2918</issn><eissn>1349-7235</eissn><abstract>Multiple myeloma (MM) is a cancer characterized by the expansion of plasma cells in the bone marrow. Survival times of patients with MM have increased due to the development of novel therapeutic agents. We herein highlight three MM cases that had a poor prognosis despite treatment with novel therapeutic agents. Of note, all patients presented with hyperammonemia that led to a consciousness disorder. The outcome for patients with MM showing high levels of serum ammonia continues to be poor, even with the use of novel therapies. 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| subjects | Ammonia Case Report Consciousness Consciousness Disorders Humans Hyperammonemia Hyperammonemia - etiology Internal medicine Multiple myeloma Multiple Myeloma - complications Plasma cells |
| title | Multiple Myeloma with Hyperammonemia Treated with Novel Agents: A Case Series of Three Patients |
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