Genomic Sequencing from Sputum for Tuberculosis Disease Diagnosis, Lineage Determination, and Drug Susceptibility Prediction

Universal access to drug susceptibility testing for newly diagnosed tuberculosis patients is recommended. Access to culture-based diagnostics remains limited, and targeted molecular assays are vulnerable to emerging resistance mutations. Improved protocols for direct-from-sputum Mycobacterium tuberc...

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Veröffentlicht in:	Journal of clinical microbiology 2023-03, Vol.61 (3), p.e0157822-e0157822
Hauptverfasser:	Nilgiriwala, Kayzad, Rabodoarivelo, Marie-Sylvianne, Hall, Michael B, Patel, Grishma, Mandal, Ayan, Mishra, Shefali, Andrianomanana, Fanantenana Randria, Dingle, Kate, Rodger, Gillian, George, Sophie, Crook, Derrick W, Hoosdally, Sarah, Mistry, Nerges, Rakotosamimanana, Niaina, Iqbal, Zamin, Grandjean Lapierre, Simon, Walker, Timothy M
Format:	Artikel
Sprache:	eng
Schlagworte:	Antimicrobial Chemotherapy Antitubercular Agents - pharmacology Antitubercular Agents - therapeutic use Genomics Humans Isoniazid Microbial Sensitivity Tests Mycobacteriology and Aerobic Actinomycetes Mycobacterium tuberculosis - genetics Rifampin Sputum - microbiology Tuberculosis - diagnosis Tuberculosis - drug therapy Tuberculosis, Multidrug-Resistant - microbiology
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