Cystic fibrosis transmembrane conductance regulator modulators attenuate platelet activation and aggregation in blood of healthy donors and COVID-19 patients

Cystic fibrosis transmembrane conductance regulator (CFTR) modulators reduce agonist-induced platelet activation and function. CFTR modulators, such as ivacaftor, present a promising therapeutic strategy in thrombocytopathies, including severe COVID-19. https://bit.ly/3HJykdt Recent work identified...

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Veröffentlicht in:	The European respiratory journal 2023-03, Vol.61 (3), p.2202009
Hauptverfasser:	Asmus, Erik, Karle, Weronika, Brack, Markus C, Wittig, Corey, Behrens, Felix, Reinshagen, Leander, Pfeiffer, Moritz, Schulz, Sabrina, Mandzimba-Maloko, Bertina, Erfinanda, Lasti, Perret, Paul L, Michalick, Laura, Smeele, Patrick J, Lim, Endry H T, van den Brom, Charissa E, Vonk, Alexander B A, Kaiser, Toralf, Suttorp, Norbert, Hippenstiel, Stefan, Sander, Leif E, Kurth, Florian, Rauch, Ursula, Landmesser, Ulf, Haghikia, Arash, Preissner, Robert, Bogaard, Harm J, Witzenrath, Martin, Kuebler, Wolfgang M, Szulcek, Robert, Simmons, Szandor
Format:	Artikel
Sprache:	eng
Schlagworte:	COVID-19 Cystic Fibrosis Cystic Fibrosis Transmembrane Conductance Regulator - genetics Health Status Humans Mutation Platelet Activation Research Letters
Online-Zugang:	Volltext
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