Microfocus computed tomography for fetal postmortem imaging: an overview
Over the last few years, fetal postmortem microfocus computed tomography (micro-CT) imaging has increased in popularity for both diagnostic and research purposes. Micro-CT imaging could be a substitute for autopsy, particularly in very early gestation fetuses for whom autopsy can be technically chal...
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Veröffentlicht in: | Pediatric radiology 2023-04, Vol.53 (4), p.632-639 |
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creator | Docter, Daniël Dawood, Yousif Jacobs, Karl Hagoort, Jaco Oostra, Roelof-Jan van den Hoff, Maurice J. B. Arthurs, Owen J. de Bakker, Bernadette S. |
description | Over the last few years, fetal postmortem microfocus computed tomography (micro-CT) imaging has increased in popularity for both diagnostic and research purposes. Micro-CT imaging could be a substitute for autopsy, particularly in very early gestation fetuses for whom autopsy can be technically challenging and is often unaccepted by parents. This article provides an overview of the latest research in fetal postmortem micro-CT imaging with a focus on diagnostic accuracy, endovascular staining approaches, placental studies and the reversibility of staining. It also discusses new methods that could prove helpful for micro-CT of larger fetuses. While more research is needed, contrast-enhanced micro-CT has the potential to become a suitable alternative to fetal autopsy. Further research using this novel imaging tool could yield wider applications, such as its practise in imaging rare museum specimens. |
doi_str_mv | 10.1007/s00247-022-05517-1 |
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While more research is needed, contrast-enhanced micro-CT has the potential to become a suitable alternative to fetal autopsy. Further research using this novel imaging tool could yield wider applications, such as its practise in imaging rare museum specimens.</description><identifier>ISSN: 1432-1998</identifier><identifier>ISSN: 0301-0449</identifier><identifier>EISSN: 1432-1998</identifier><identifier>DOI: 10.1007/s00247-022-05517-1</identifier><identifier>PMID: 36169668</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Accuracy ; Autopsies ; Autopsy ; Autopsy - methods ; Cardiovascular system ; Computed tomography ; Deoxyribonucleic acid ; DNA ; Espr ; Female ; Fetus - diagnostic imaging ; Fetuses ; Gestational Age ; Humans ; Imaging ; Iodine ; Magnetic Resonance Imaging - methods ; Medical imaging ; Medicine ; Medicine & Public Health ; Neuroradiology ; Nuclear Medicine ; Oncology ; Parents & parenting ; Pediatrics ; Placenta - diagnostic imaging ; Potassium ; Pregnancy ; Radiation ; Radiology ; Staining ; Stillbirth ; Tomography ; Ultrasound ; X-Ray Microtomography - methods</subject><ispartof>Pediatric radiology, 2023-04, Vol.53 (4), p.632-639</ispartof><rights>The Author(s) 2022</rights><rights>2022. The Author(s).</rights><rights>The Author(s) 2022. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). 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B.</creatorcontrib><creatorcontrib>Arthurs, Owen J.</creatorcontrib><creatorcontrib>de Bakker, Bernadette S.</creatorcontrib><title>Microfocus computed tomography for fetal postmortem imaging: an overview</title><title>Pediatric radiology</title><addtitle>Pediatr Radiol</addtitle><addtitle>Pediatr Radiol</addtitle><description>Over the last few years, fetal postmortem microfocus computed tomography (micro-CT) imaging has increased in popularity for both diagnostic and research purposes. Micro-CT imaging could be a substitute for autopsy, particularly in very early gestation fetuses for whom autopsy can be technically challenging and is often unaccepted by parents. This article provides an overview of the latest research in fetal postmortem micro-CT imaging with a focus on diagnostic accuracy, endovascular staining approaches, placental studies and the reversibility of staining. It also discusses new methods that could prove helpful for micro-CT of larger fetuses. While more research is needed, contrast-enhanced micro-CT has the potential to become a suitable alternative to fetal autopsy. Further research using this novel imaging tool could yield wider applications, such as its practise in imaging rare museum specimens.</description><subject>Accuracy</subject><subject>Autopsies</subject><subject>Autopsy</subject><subject>Autopsy - methods</subject><subject>Cardiovascular system</subject><subject>Computed tomography</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>Espr</subject><subject>Female</subject><subject>Fetus - diagnostic imaging</subject><subject>Fetuses</subject><subject>Gestational Age</subject><subject>Humans</subject><subject>Imaging</subject><subject>Iodine</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Medical imaging</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Neuroradiology</subject><subject>Nuclear Medicine</subject><subject>Oncology</subject><subject>Parents & parenting</subject><subject>Pediatrics</subject><subject>Placenta - diagnostic imaging</subject><subject>Potassium</subject><subject>Pregnancy</subject><subject>Radiation</subject><subject>Radiology</subject><subject>Staining</subject><subject>Stillbirth</subject><subject>Tomography</subject><subject>Ultrasound</subject><subject>X-Ray Microtomography - methods</subject><issn>1432-1998</issn><issn>0301-0449</issn><issn>1432-1998</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kT9PwzAQxS0EoqXwBRhQJBaWgP_EdsyCUAUUqYgFZst1nDRVEgc7Keq3x9BSCgOTLd3v3r27B8ApgpcIQn7lIcQJjyHGMaQU8RjtgSFKCI6REOn-zn8AjrxfQAgJReQQDAhDTDCWDsHkqdTO5lb3PtK2bvvOZFFna1s41c5XUW5dlJtOVVFrfVdb15k6KmtVlE1xHakmskvjlqV5PwYHuaq8Odm8I_B6f_cynsTT54fH8e001gmnXUyE0JlhuRZ0xmieUJzQYHPGFNcGc6QzjDVnCgmleIK0oZhzhAnMciZ4CskI3Kx1235Wm0ybpnOqkq0LptxKWlXK35WmnMvCLmU4GeYsIUHhYqPg7FtvfCfr0mtTVaoxtvcyuEgFQ1TQgJ7_QRe2d03YL1BpSnlCIA8UXlPhkt47k2_dIPg5lst1UjIkJb-Skig0ne3usW35jiYAZA34UGoK435m_yP7AcC7nv4</recordid><startdate>20230401</startdate><enddate>20230401</enddate><creator>Docter, Daniël</creator><creator>Dawood, Yousif</creator><creator>Jacobs, Karl</creator><creator>Hagoort, Jaco</creator><creator>Oostra, Roelof-Jan</creator><creator>van den Hoff, Maurice J. 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subjects | Accuracy Autopsies Autopsy Autopsy - methods Cardiovascular system Computed tomography Deoxyribonucleic acid DNA Espr Female Fetus - diagnostic imaging Fetuses Gestational Age Humans Imaging Iodine Magnetic Resonance Imaging - methods Medical imaging Medicine Medicine & Public Health Neuroradiology Nuclear Medicine Oncology Parents & parenting Pediatrics Placenta - diagnostic imaging Potassium Pregnancy Radiation Radiology Staining Stillbirth Tomography Ultrasound X-Ray Microtomography - methods |
title | Microfocus computed tomography for fetal postmortem imaging: an overview |
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