Microfocus computed tomography for fetal postmortem imaging: an overview

Over the last few years, fetal postmortem microfocus computed tomography (micro-CT) imaging has increased in popularity for both diagnostic and research purposes. Micro-CT imaging could be a substitute for autopsy, particularly in very early gestation fetuses for whom autopsy can be technically chal...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Pediatric radiology 2023-04, Vol.53 (4), p.632-639
Hauptverfasser: Docter, Daniël, Dawood, Yousif, Jacobs, Karl, Hagoort, Jaco, Oostra, Roelof-Jan, van den Hoff, Maurice J. B., Arthurs, Owen J., de Bakker, Bernadette S.
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 639
container_issue 4
container_start_page 632
container_title Pediatric radiology
container_volume 53
creator Docter, Daniël
Dawood, Yousif
Jacobs, Karl
Hagoort, Jaco
Oostra, Roelof-Jan
van den Hoff, Maurice J. B.
Arthurs, Owen J.
de Bakker, Bernadette S.
description Over the last few years, fetal postmortem microfocus computed tomography (micro-CT) imaging has increased in popularity for both diagnostic and research purposes. Micro-CT imaging could be a substitute for autopsy, particularly in very early gestation fetuses for whom autopsy can be technically challenging and is often unaccepted by parents. This article provides an overview of the latest research in fetal postmortem micro-CT imaging with a focus on diagnostic accuracy, endovascular staining approaches, placental studies and the reversibility of staining. It also discusses new methods that could prove helpful for micro-CT of larger fetuses. While more research is needed, contrast-enhanced micro-CT has the potential to become a suitable alternative to fetal autopsy. Further research using this novel imaging tool could yield wider applications, such as its practise in imaging rare museum specimens.
doi_str_mv 10.1007/s00247-022-05517-1
format Article
fullrecord <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10027643</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2788574307</sourcerecordid><originalsourceid>FETCH-LOGICAL-c475t-399cde6fc95b65f45245143b6a7ce271cd22c76a19aa741ce52771230df697803</originalsourceid><addsrcrecordid>eNp9kT9PwzAQxS0EoqXwBRhQJBaWgP_EdsyCUAUUqYgFZst1nDRVEgc7Keq3x9BSCgOTLd3v3r27B8ApgpcIQn7lIcQJjyHGMaQU8RjtgSFKCI6REOn-zn8AjrxfQAgJReQQDAhDTDCWDsHkqdTO5lb3PtK2bvvOZFFna1s41c5XUW5dlJtOVVFrfVdb15k6KmtVlE1xHakmskvjlqV5PwYHuaq8Odm8I_B6f_cynsTT54fH8e001gmnXUyE0JlhuRZ0xmieUJzQYHPGFNcGc6QzjDVnCgmleIK0oZhzhAnMciZ4CskI3Kx1235Wm0ybpnOqkq0LptxKWlXK35WmnMvCLmU4GeYsIUHhYqPg7FtvfCfr0mtTVaoxtvcyuEgFQ1TQgJ7_QRe2d03YL1BpSnlCIA8UXlPhkt47k2_dIPg5lst1UjIkJb-Skig0ne3usW35jiYAZA34UGoK435m_yP7AcC7nv4</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2788574307</pqid></control><display><type>article</type><title>Microfocus computed tomography for fetal postmortem imaging: an overview</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>Docter, Daniël ; Dawood, Yousif ; Jacobs, Karl ; Hagoort, Jaco ; Oostra, Roelof-Jan ; van den Hoff, Maurice J. B. ; Arthurs, Owen J. ; de Bakker, Bernadette S.</creator><creatorcontrib>Docter, Daniël ; Dawood, Yousif ; Jacobs, Karl ; Hagoort, Jaco ; Oostra, Roelof-Jan ; van den Hoff, Maurice J. B. ; Arthurs, Owen J. ; de Bakker, Bernadette S.</creatorcontrib><description>Over the last few years, fetal postmortem microfocus computed tomography (micro-CT) imaging has increased in popularity for both diagnostic and research purposes. Micro-CT imaging could be a substitute for autopsy, particularly in very early gestation fetuses for whom autopsy can be technically challenging and is often unaccepted by parents. This article provides an overview of the latest research in fetal postmortem micro-CT imaging with a focus on diagnostic accuracy, endovascular staining approaches, placental studies and the reversibility of staining. It also discusses new methods that could prove helpful for micro-CT of larger fetuses. While more research is needed, contrast-enhanced micro-CT has the potential to become a suitable alternative to fetal autopsy. Further research using this novel imaging tool could yield wider applications, such as its practise in imaging rare museum specimens.</description><identifier>ISSN: 1432-1998</identifier><identifier>ISSN: 0301-0449</identifier><identifier>EISSN: 1432-1998</identifier><identifier>DOI: 10.1007/s00247-022-05517-1</identifier><identifier>PMID: 36169668</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Accuracy ; Autopsies ; Autopsy ; Autopsy - methods ; Cardiovascular system ; Computed tomography ; Deoxyribonucleic acid ; DNA ; Espr ; Female ; Fetus - diagnostic imaging ; Fetuses ; Gestational Age ; Humans ; Imaging ; Iodine ; Magnetic Resonance Imaging - methods ; Medical imaging ; Medicine ; Medicine &amp; Public Health ; Neuroradiology ; Nuclear Medicine ; Oncology ; Parents &amp; parenting ; Pediatrics ; Placenta - diagnostic imaging ; Potassium ; Pregnancy ; Radiation ; Radiology ; Staining ; Stillbirth ; Tomography ; Ultrasound ; X-Ray Microtomography - methods</subject><ispartof>Pediatric radiology, 2023-04, Vol.53 (4), p.632-639</ispartof><rights>The Author(s) 2022</rights><rights>2022. The Author(s).</rights><rights>The Author(s) 2022. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c475t-399cde6fc95b65f45245143b6a7ce271cd22c76a19aa741ce52771230df697803</citedby><cites>FETCH-LOGICAL-c475t-399cde6fc95b65f45245143b6a7ce271cd22c76a19aa741ce52771230df697803</cites><orcidid>0000-0003-0758-4064</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00247-022-05517-1$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00247-022-05517-1$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36169668$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Docter, Daniël</creatorcontrib><creatorcontrib>Dawood, Yousif</creatorcontrib><creatorcontrib>Jacobs, Karl</creatorcontrib><creatorcontrib>Hagoort, Jaco</creatorcontrib><creatorcontrib>Oostra, Roelof-Jan</creatorcontrib><creatorcontrib>van den Hoff, Maurice J. B.</creatorcontrib><creatorcontrib>Arthurs, Owen J.</creatorcontrib><creatorcontrib>de Bakker, Bernadette S.</creatorcontrib><title>Microfocus computed tomography for fetal postmortem imaging: an overview</title><title>Pediatric radiology</title><addtitle>Pediatr Radiol</addtitle><addtitle>Pediatr Radiol</addtitle><description>Over the last few years, fetal postmortem microfocus computed tomography (micro-CT) imaging has increased in popularity for both diagnostic and research purposes. Micro-CT imaging could be a substitute for autopsy, particularly in very early gestation fetuses for whom autopsy can be technically challenging and is often unaccepted by parents. This article provides an overview of the latest research in fetal postmortem micro-CT imaging with a focus on diagnostic accuracy, endovascular staining approaches, placental studies and the reversibility of staining. It also discusses new methods that could prove helpful for micro-CT of larger fetuses. While more research is needed, contrast-enhanced micro-CT has the potential to become a suitable alternative to fetal autopsy. Further research using this novel imaging tool could yield wider applications, such as its practise in imaging rare museum specimens.</description><subject>Accuracy</subject><subject>Autopsies</subject><subject>Autopsy</subject><subject>Autopsy - methods</subject><subject>Cardiovascular system</subject><subject>Computed tomography</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>Espr</subject><subject>Female</subject><subject>Fetus - diagnostic imaging</subject><subject>Fetuses</subject><subject>Gestational Age</subject><subject>Humans</subject><subject>Imaging</subject><subject>Iodine</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Medical imaging</subject><subject>Medicine</subject><subject>Medicine &amp; Public Health</subject><subject>Neuroradiology</subject><subject>Nuclear Medicine</subject><subject>Oncology</subject><subject>Parents &amp; parenting</subject><subject>Pediatrics</subject><subject>Placenta - diagnostic imaging</subject><subject>Potassium</subject><subject>Pregnancy</subject><subject>Radiation</subject><subject>Radiology</subject><subject>Staining</subject><subject>Stillbirth</subject><subject>Tomography</subject><subject>Ultrasound</subject><subject>X-Ray Microtomography - methods</subject><issn>1432-1998</issn><issn>0301-0449</issn><issn>1432-1998</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kT9PwzAQxS0EoqXwBRhQJBaWgP_EdsyCUAUUqYgFZst1nDRVEgc7Keq3x9BSCgOTLd3v3r27B8ApgpcIQn7lIcQJjyHGMaQU8RjtgSFKCI6REOn-zn8AjrxfQAgJReQQDAhDTDCWDsHkqdTO5lb3PtK2bvvOZFFna1s41c5XUW5dlJtOVVFrfVdb15k6KmtVlE1xHakmskvjlqV5PwYHuaq8Odm8I_B6f_cynsTT54fH8e001gmnXUyE0JlhuRZ0xmieUJzQYHPGFNcGc6QzjDVnCgmleIK0oZhzhAnMciZ4CskI3Kx1235Wm0ybpnOqkq0LptxKWlXK35WmnMvCLmU4GeYsIUHhYqPg7FtvfCfr0mtTVaoxtvcyuEgFQ1TQgJ7_QRe2d03YL1BpSnlCIA8UXlPhkt47k2_dIPg5lst1UjIkJb-Skig0ne3usW35jiYAZA34UGoK435m_yP7AcC7nv4</recordid><startdate>20230401</startdate><enddate>20230401</enddate><creator>Docter, Daniël</creator><creator>Dawood, Yousif</creator><creator>Jacobs, Karl</creator><creator>Hagoort, Jaco</creator><creator>Oostra, Roelof-Jan</creator><creator>van den Hoff, Maurice J. B.</creator><creator>Arthurs, Owen J.</creator><creator>de Bakker, Bernadette S.</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7TK</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-0758-4064</orcidid></search><sort><creationdate>20230401</creationdate><title>Microfocus computed tomography for fetal postmortem imaging: an overview</title><author>Docter, Daniël ; Dawood, Yousif ; Jacobs, Karl ; Hagoort, Jaco ; Oostra, Roelof-Jan ; van den Hoff, Maurice J. B. ; Arthurs, Owen J. ; de Bakker, Bernadette S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c475t-399cde6fc95b65f45245143b6a7ce271cd22c76a19aa741ce52771230df697803</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Accuracy</topic><topic>Autopsies</topic><topic>Autopsy</topic><topic>Autopsy - methods</topic><topic>Cardiovascular system</topic><topic>Computed tomography</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>Espr</topic><topic>Female</topic><topic>Fetus - diagnostic imaging</topic><topic>Fetuses</topic><topic>Gestational Age</topic><topic>Humans</topic><topic>Imaging</topic><topic>Iodine</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Medical imaging</topic><topic>Medicine</topic><topic>Medicine &amp; Public Health</topic><topic>Neuroradiology</topic><topic>Nuclear Medicine</topic><topic>Oncology</topic><topic>Parents &amp; parenting</topic><topic>Pediatrics</topic><topic>Placenta - diagnostic imaging</topic><topic>Potassium</topic><topic>Pregnancy</topic><topic>Radiation</topic><topic>Radiology</topic><topic>Staining</topic><topic>Stillbirth</topic><topic>Tomography</topic><topic>Ultrasound</topic><topic>X-Ray Microtomography - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Docter, Daniël</creatorcontrib><creatorcontrib>Dawood, Yousif</creatorcontrib><creatorcontrib>Jacobs, Karl</creatorcontrib><creatorcontrib>Hagoort, Jaco</creatorcontrib><creatorcontrib>Oostra, Roelof-Jan</creatorcontrib><creatorcontrib>van den Hoff, Maurice J. B.</creatorcontrib><creatorcontrib>Arthurs, Owen J.</creatorcontrib><creatorcontrib>de Bakker, Bernadette S.</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium &amp; Calcified Tissue Abstracts</collection><collection>Nursing &amp; Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies &amp; Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Nursing &amp; Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Consumer Health Database</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Nursing &amp; Allied Health Premium</collection><collection>Advanced Technologies &amp; Aerospace Database</collection><collection>ProQuest Advanced Technologies &amp; Aerospace Collection</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Pediatric radiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Docter, Daniël</au><au>Dawood, Yousif</au><au>Jacobs, Karl</au><au>Hagoort, Jaco</au><au>Oostra, Roelof-Jan</au><au>van den Hoff, Maurice J. B.</au><au>Arthurs, Owen J.</au><au>de Bakker, Bernadette S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Microfocus computed tomography for fetal postmortem imaging: an overview</atitle><jtitle>Pediatric radiology</jtitle><stitle>Pediatr Radiol</stitle><addtitle>Pediatr Radiol</addtitle><date>2023-04-01</date><risdate>2023</risdate><volume>53</volume><issue>4</issue><spage>632</spage><epage>639</epage><pages>632-639</pages><issn>1432-1998</issn><issn>0301-0449</issn><eissn>1432-1998</eissn><abstract>Over the last few years, fetal postmortem microfocus computed tomography (micro-CT) imaging has increased in popularity for both diagnostic and research purposes. Micro-CT imaging could be a substitute for autopsy, particularly in very early gestation fetuses for whom autopsy can be technically challenging and is often unaccepted by parents. This article provides an overview of the latest research in fetal postmortem micro-CT imaging with a focus on diagnostic accuracy, endovascular staining approaches, placental studies and the reversibility of staining. It also discusses new methods that could prove helpful for micro-CT of larger fetuses. While more research is needed, contrast-enhanced micro-CT has the potential to become a suitable alternative to fetal autopsy. Further research using this novel imaging tool could yield wider applications, such as its practise in imaging rare museum specimens.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>36169668</pmid><doi>10.1007/s00247-022-05517-1</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0003-0758-4064</orcidid><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1432-1998
ispartof Pediatric radiology, 2023-04, Vol.53 (4), p.632-639
issn 1432-1998
0301-0449
1432-1998
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10027643
source MEDLINE; SpringerLink Journals
subjects Accuracy
Autopsies
Autopsy
Autopsy - methods
Cardiovascular system
Computed tomography
Deoxyribonucleic acid
DNA
Espr
Female
Fetus - diagnostic imaging
Fetuses
Gestational Age
Humans
Imaging
Iodine
Magnetic Resonance Imaging - methods
Medical imaging
Medicine
Medicine & Public Health
Neuroradiology
Nuclear Medicine
Oncology
Parents & parenting
Pediatrics
Placenta - diagnostic imaging
Potassium
Pregnancy
Radiation
Radiology
Staining
Stillbirth
Tomography
Ultrasound
X-Ray Microtomography - methods
title Microfocus computed tomography for fetal postmortem imaging: an overview
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-29T04%3A09%3A25IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Microfocus%20computed%20tomography%20for%20fetal%20postmortem%20imaging:%20an%20overview&rft.jtitle=Pediatric%20radiology&rft.au=Docter,%20Dani%C3%ABl&rft.date=2023-04-01&rft.volume=53&rft.issue=4&rft.spage=632&rft.epage=639&rft.pages=632-639&rft.issn=1432-1998&rft.eissn=1432-1998&rft_id=info:doi/10.1007/s00247-022-05517-1&rft_dat=%3Cproquest_pubme%3E2788574307%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2788574307&rft_id=info:pmid/36169668&rfr_iscdi=true