p38 MAPK and MKP-1 control the glycolytic program via the bifunctional glycolysis regulator PFKFB3 during sepsis

Hyperlactatemia often occurs in critically ill patients during severe sepsis/septic shock and is a powerful predictor of mortality. Lactate is the end product of glycolysis. While hypoxia due to inadequate oxygen delivery may result in anaerobic glycolysis, sepsis also enhances glycolysis under hype...

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Veröffentlicht in:	The Journal of biological chemistry 2023-04, Vol.299 (4), p.103043-103043, Article 103043
Hauptverfasser:	Mager, Carli E., Mormol, Justin M., Shelton, Evan D., Murphy, Parker R., Bowman, Bridget A., Barley, Timothy J., Wang, Xiantao, Linn, Sarah C., Liu, Kevin, Nelin, Leif D., Hafner, Markus, Liu, Yusen
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals c-Jun N-terminal kinase Dual Specificity Phosphatase 1 - genetics Dual Specificity Phosphatase 1 - metabolism dual-specificity phosphoprotein phosphatase Escherichia coli - metabolism Glycolysis infection Lactates Lipopolysaccharides Mice Oxygen p38 MAPK p38 Mitogen-Activated Protein Kinases - metabolism Phosphofructokinase-2 - metabolism Protein Tyrosine Phosphatases - metabolism sepsis Sepsis - genetics
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