Discovery of a Transferrin Receptor 1‑Binding Aptamer and Its Application in Cancer Cell Depletion for Adoptive T‑Cell Therapy Manufacturing

The clinical manufacturing of chimeric antigen receptor (CAR) T cells includes cell selection, activation, gene transduction, and expansion. While the method of T-cell selection varies across companies, current methods do not actively eliminate the cancer cells in the patient’s apheresis product fro...

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Veröffentlicht in:	Journal of the American Chemical Society 2022-08, Vol.144 (30), p.13851-13864
Hauptverfasser:	Cheng, Emmeline L., Cardle, Ian I., Kacherovsky, Nataly, Bansia, Harsh, Wang, Tong, Zhou, Yunshi, Raman, Jai, Yen, Albert, Gutierrez, Dominique, Salipante, Stephen J., des Georges, Amédée, Jensen, Michael C., Pun, Suzie H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell- and Tissue-Based Therapy Humans Leukocytes, Mononuclear Neoplasms - metabolism Receptors, Antigen, T-Cell - metabolism Receptors, Chimeric Antigen - genetics Receptors, Transferrin - metabolism T-Lymphocytes
Online-Zugang:	Volltext
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