Distinct role of ERp57 and ERdj5 as a disulfide isomerase and reductase during ER protein folding

Proteins entering the secretory pathway need to attain native disulfide pairings to fold correctly. For proteins with complex disulfides, this process requires the reduction and isomerisation of non-native disulfides. Two key members of the protein disulfide isomerase (PDI) family, ERp57 and ERdj5 (...

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Veröffentlicht in:	Journal of cell science 2023-01, Vol.136 (2)
Hauptverfasser:	Robinson, Philip John, Pringle, Marie Anne, Fleming, Bethany, Bulleid, Neil John
Format:	Artikel
Sprache:	eng
Schlagworte:	Disulfides - metabolism Glycoproteins - metabolism Oxidation-Reduction Oxidoreductases - metabolism Protein Disulfide-Isomerases - chemistry Protein Disulfide-Isomerases - genetics Protein Disulfide-Isomerases - metabolism Protein Folding
Online-Zugang:	Volltext
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