Antibodies to the five histones and poly(adenosine diphosphate-ribose) in drug induced lupus: implications for pathogenesis
Certain drugs are a frequent source of antinuclear antibody (ANA) induction, and ANA is invariably present in the few patients who progress to the drug induced lupus syndrome. This report concerns the fine specificity of the ANA response to hydralazine, penicillamine, and sulphasalazine therapy. Usi...
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| Veröffentlicht in: | Annals of the rheumatic diseases 1987-05, Vol.46 (5), p.408-416 |
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| creator | Hobbs, R N Clayton, A L Bernstein, R M |
| description | Certain drugs are a frequent source of antinuclear antibody (ANA) induction, and ANA is invariably present in the few patients who progress to the drug induced lupus syndrome. This report concerns the fine specificity of the ANA response to hydralazine, penicillamine, and sulphasalazine therapy. Using highly purified individual histones in fluorimetric assays, antihistone antibodies are always detectable, often in large amounts, but the pattern of response to individual histones is variable and not drug specific. In addition to the response to the three histones H1, H2B, and H3 reminiscent of idiopathic systemic lupus erythematosus, antibody to histone H2A predominates in some drug induced cases. Contrary to previous thought, histones are not the sole target of the antinuclear response: we also demonstrate a significant correlation between ANA titre and antibody to poly(adenosine diphosphate-ribose). Like the histones, this is a macromolecule that can bind to deoxyribonucleic acid (DNA). It is proposed that drug induced damage to chromatin leads to ANA production, while drug induced impairment of complement activity may then enable these autoantibodies to mediate the lupus syndrome. |
| doi_str_mv | 10.1136/ard.46.5.408 |
| format | Article |
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This report concerns the fine specificity of the ANA response to hydralazine, penicillamine, and sulphasalazine therapy. Using highly purified individual histones in fluorimetric assays, antihistone antibodies are always detectable, often in large amounts, but the pattern of response to individual histones is variable and not drug specific. In addition to the response to the three histones H1, H2B, and H3 reminiscent of idiopathic systemic lupus erythematosus, antibody to histone H2A predominates in some drug induced cases. Contrary to previous thought, histones are not the sole target of the antinuclear response: we also demonstrate a significant correlation between ANA titre and antibody to poly(adenosine diphosphate-ribose). Like the histones, this is a macromolecule that can bind to deoxyribonucleic acid (DNA). It is proposed that drug induced damage to chromatin leads to ANA production, while drug induced impairment of complement activity may then enable these autoantibodies to mediate the lupus syndrome.</description><identifier>ISSN: 0003-4967</identifier><identifier>EISSN: 1468-2060</identifier><identifier>DOI: 10.1136/ard.46.5.408</identifier><identifier>PMID: 2884934</identifier><identifier>CODEN: ARDIAO</identifier><language>eng</language><publisher>London: BMJ Publishing Group Ltd and European League Against Rheumatism</publisher><subject>Antibodies, Antinuclear - analysis ; Biological and medical sciences ; Drug toxicity and drugs side effects treatment ; Histones - immunology ; Humans ; Hydralazine - adverse effects ; Lupus Erythematosus, Systemic - chemically induced ; Lupus Erythematosus, Systemic - immunology ; Medical sciences ; Nucleoside Diphosphate Sugars - immunology ; Penicillamine - adverse effects ; Pharmacology. Drug treatments ; Poly Adenosine Diphosphate Ribose - immunology ; Sulfasalazine - adverse effects ; Toxicity: skin, dermoskeleton</subject><ispartof>Annals of the rheumatic diseases, 1987-05, Vol.46 (5), p.408-416</ispartof><rights>1988 INIST-CNRS</rights><rights>Copyright BMJ Publishing Group LTD May 1987</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b4218-198d2898403873c1aed9fd33029fd54b1e8f15d45c970fcf28e9619b516038e13</citedby><cites>FETCH-LOGICAL-b4218-198d2898403873c1aed9fd33029fd54b1e8f15d45c970fcf28e9619b516038e13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1002151/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1002151/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,724,777,781,882,27905,27906,53772,53774</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7531024$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2884934$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hobbs, R N</creatorcontrib><creatorcontrib>Clayton, A L</creatorcontrib><creatorcontrib>Bernstein, R M</creatorcontrib><title>Antibodies to the five histones and poly(adenosine diphosphate-ribose) in drug induced lupus: implications for pathogenesis</title><title>Annals of the rheumatic diseases</title><addtitle>Ann Rheum Dis</addtitle><description>Certain drugs are a frequent source of antinuclear antibody (ANA) induction, and ANA is invariably present in the few patients who progress to the drug induced lupus syndrome. This report concerns the fine specificity of the ANA response to hydralazine, penicillamine, and sulphasalazine therapy. Using highly purified individual histones in fluorimetric assays, antihistone antibodies are always detectable, often in large amounts, but the pattern of response to individual histones is variable and not drug specific. In addition to the response to the three histones H1, H2B, and H3 reminiscent of idiopathic systemic lupus erythematosus, antibody to histone H2A predominates in some drug induced cases. Contrary to previous thought, histones are not the sole target of the antinuclear response: we also demonstrate a significant correlation between ANA titre and antibody to poly(adenosine diphosphate-ribose). Like the histones, this is a macromolecule that can bind to deoxyribonucleic acid (DNA). It is proposed that drug induced damage to chromatin leads to ANA production, while drug induced impairment of complement activity may then enable these autoantibodies to mediate the lupus syndrome.</description><subject>Antibodies, Antinuclear - analysis</subject><subject>Biological and medical sciences</subject><subject>Drug toxicity and drugs side effects treatment</subject><subject>Histones - immunology</subject><subject>Humans</subject><subject>Hydralazine - adverse effects</subject><subject>Lupus Erythematosus, Systemic - chemically induced</subject><subject>Lupus Erythematosus, Systemic - immunology</subject><subject>Medical sciences</subject><subject>Nucleoside Diphosphate Sugars - immunology</subject><subject>Penicillamine - adverse effects</subject><subject>Pharmacology. Drug treatments</subject><subject>Poly Adenosine Diphosphate Ribose - immunology</subject><subject>Sulfasalazine - adverse effects</subject><subject>Toxicity: skin, dermoskeleton</subject><issn>0003-4967</issn><issn>1468-2060</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kd2L1DAUxYMo6-zqm69CQGEV7Jg0aZr4ICyD7irrx8Pqa0ib22nGTlKTdnHxnzfDDIO--HRJzu-ee-Ag9ISSJaVMvDbRLrlYVktO5D20oFzIoiSC3EcLQggruBL1Q3Sa0iY_iaTyBJ2UUnLF-AL9vvCTa4J1kPAU8NQD7twt4N6lKfj8abzFYxjuXhgLPiTnAVs39iGNvZmgiHk5wUvsPLZxXudp5xYsHuZxTm-w246Da83kgk-4CxGPZurDGrKzS4_Qg84MCR4f5hn69v7dzeqquP5y-WF1cV00vKSyoEraUirJCZM1a6kBqzrLGCnzqHhDQXa0srxqVU26tislKEFVU1GRN4CyM_R27zvOzRZsC36KZtBjdFsT73QwTv-reNfrdbjVlJCSVjuDZweDGH7OkCa9CXP0ObOmtVA1I4KyTL3aU20MKUXojhco0bumdG5Kc6ErnZvK-NO_Ux3hQzVZf37QTWrN0EXjW5eOWF0xSsodVuyxXBj8Osom_tCiZnWlP39f6auvn8THGyn1ZebP93yz3fw_4B_jOrmD</recordid><startdate>19870501</startdate><enddate>19870501</enddate><creator>Hobbs, R N</creator><creator>Clayton, A L</creator><creator>Bernstein, R M</creator><general>BMJ Publishing Group Ltd and European League Against Rheumatism</general><general>BMJ</general><general>Elsevier Limited</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>LK8</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>5PM</scope></search><sort><creationdate>19870501</creationdate><title>Antibodies to the five histones and poly(adenosine diphosphate-ribose) in drug induced lupus: implications for pathogenesis</title><author>Hobbs, R N ; Clayton, A L ; Bernstein, R M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b4218-198d2898403873c1aed9fd33029fd54b1e8f15d45c970fcf28e9619b516038e13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>Antibodies, Antinuclear - analysis</topic><topic>Biological and medical sciences</topic><topic>Drug toxicity and drugs side effects treatment</topic><topic>Histones - immunology</topic><topic>Humans</topic><topic>Hydralazine - adverse effects</topic><topic>Lupus Erythematosus, Systemic - chemically induced</topic><topic>Lupus Erythematosus, Systemic - immunology</topic><topic>Medical sciences</topic><topic>Nucleoside Diphosphate Sugars - immunology</topic><topic>Penicillamine - adverse effects</topic><topic>Pharmacology. Drug treatments</topic><topic>Poly Adenosine Diphosphate Ribose - immunology</topic><topic>Sulfasalazine - adverse effects</topic><topic>Toxicity: skin, dermoskeleton</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hobbs, R N</creatorcontrib><creatorcontrib>Clayton, A L</creatorcontrib><creatorcontrib>Bernstein, R M</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medicine (ProQuest)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection (Proquest) (PQ_SDU_P3)</collection><collection>Consumer Health Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Family Health Database (ProQuest)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>ProQuest Science Journals</collection><collection>ProQuest Biological Science Journals</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Annals of the rheumatic diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hobbs, R N</au><au>Clayton, A L</au><au>Bernstein, R M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antibodies to the five histones and poly(adenosine diphosphate-ribose) in drug induced lupus: implications for pathogenesis</atitle><jtitle>Annals of the rheumatic diseases</jtitle><addtitle>Ann Rheum Dis</addtitle><date>1987-05-01</date><risdate>1987</risdate><volume>46</volume><issue>5</issue><spage>408</spage><epage>416</epage><pages>408-416</pages><issn>0003-4967</issn><eissn>1468-2060</eissn><coden>ARDIAO</coden><abstract>Certain drugs are a frequent source of antinuclear antibody (ANA) induction, and ANA is invariably present in the few patients who progress to the drug induced lupus syndrome. This report concerns the fine specificity of the ANA response to hydralazine, penicillamine, and sulphasalazine therapy. Using highly purified individual histones in fluorimetric assays, antihistone antibodies are always detectable, often in large amounts, but the pattern of response to individual histones is variable and not drug specific. In addition to the response to the three histones H1, H2B, and H3 reminiscent of idiopathic systemic lupus erythematosus, antibody to histone H2A predominates in some drug induced cases. Contrary to previous thought, histones are not the sole target of the antinuclear response: we also demonstrate a significant correlation between ANA titre and antibody to poly(adenosine diphosphate-ribose). Like the histones, this is a macromolecule that can bind to deoxyribonucleic acid (DNA). It is proposed that drug induced damage to chromatin leads to ANA production, while drug induced impairment of complement activity may then enable these autoantibodies to mediate the lupus syndrome.</abstract><cop>London</cop><pub>BMJ Publishing Group Ltd and European League Against Rheumatism</pub><pmid>2884934</pmid><doi>10.1136/ard.46.5.408</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Annals of the rheumatic diseases, 1987-05, Vol.46 (5), p.408-416 |
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| subjects | Antibodies, Antinuclear - analysis Biological and medical sciences Drug toxicity and drugs side effects treatment Histones - immunology Humans Hydralazine - adverse effects Lupus Erythematosus, Systemic - chemically induced Lupus Erythematosus, Systemic - immunology Medical sciences Nucleoside Diphosphate Sugars - immunology Penicillamine - adverse effects Pharmacology. Drug treatments Poly Adenosine Diphosphate Ribose - immunology Sulfasalazine - adverse effects Toxicity: skin, dermoskeleton |
| title | Antibodies to the five histones and poly(adenosine diphosphate-ribose) in drug induced lupus: implications for pathogenesis |
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