Combination of methylprednisolone pulse therapy and remission inducing drugs in rheumatoid arthritis

Thirty patients with rheumatoid arthritis were allocated to either methylprednisolone pulse therapy or placebo at the beginning of treatment with either gold salts, penicillamine, or azathioprine. Methylprednisolone pulse therapy produced an immediate but temporary anti-inflammatory effect lasting f...

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Veröffentlicht in:Annals of the rheumatic diseases 1987-04, Vol.46 (4), p.290-295
Hauptverfasser: Hansen, T M, Dickmeiss, E, Jans, H, Ingemann Hansen, T, Ingeman-Nielsen, M, Lorenzen, I
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container_end_page 295
container_issue 4
container_start_page 290
container_title Annals of the rheumatic diseases
container_volume 46
creator Hansen, T M
Dickmeiss, E
Jans, H
Ingemann Hansen, T
Ingeman-Nielsen, M
Lorenzen, I
description Thirty patients with rheumatoid arthritis were allocated to either methylprednisolone pulse therapy or placebo at the beginning of treatment with either gold salts, penicillamine, or azathioprine. Methylprednisolone pulse therapy produced an immediate but temporary anti-inflammatory effect lasting for a maximum of four to eight weeks. It also caused a lasting depression of serum IgG, but no effect was observed on the proportion of T and B lymphocytes, proliferative responses, or on concanavalin A induced suppressor cell activity, and there was no effect on the amount of circulating immune complexes. The bone mineral content decreased similarly in the two groups, and methylprednisolone pulses had no effect on the progression of erosions on x rays during an observation period of eight months. A single pulse of methylprednisolone can give a short lasting anti-inflammatory effect but is of little or no value in the long term treatment of rheumatoid arthritis.
doi_str_mv 10.1136/ard.46.4.290
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Methylprednisolone pulse therapy produced an immediate but temporary anti-inflammatory effect lasting for a maximum of four to eight weeks. It also caused a lasting depression of serum IgG, but no effect was observed on the proportion of T and B lymphocytes, proliferative responses, or on concanavalin A induced suppressor cell activity, and there was no effect on the amount of circulating immune complexes. The bone mineral content decreased similarly in the two groups, and methylprednisolone pulses had no effect on the progression of erosions on x rays during an observation period of eight months. A single pulse of methylprednisolone can give a short lasting anti-inflammatory effect but is of little or no value in the long term treatment of rheumatoid arthritis.</description><identifier>ISSN: 0003-4967</identifier><identifier>EISSN: 1468-2060</identifier><identifier>DOI: 10.1136/ard.46.4.290</identifier><identifier>PMID: 3296967</identifier><identifier>CODEN: ARDIAO</identifier><language>eng</language><publisher>London: BMJ Publishing Group Ltd and European League Against Rheumatism</publisher><subject>Adult ; Aged ; Arthritis, Rheumatoid - blood ; Arthritis, Rheumatoid - drug therapy ; Arthritis, Rheumatoid - pathology ; Azathioprine - therapeutic use ; Biological and medical sciences ; Bones, joints and connective tissue. Antiinflammatory agents ; Clinical Trials as Topic ; Double-Blind Method ; Drug Therapy, Combination ; Female ; Gold - therapeutic use ; Humans ; Male ; Medical sciences ; Methylprednisolone - administration &amp; dosage ; Middle Aged ; Penicillamine - therapeutic use ; Pharmacology. 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Methylprednisolone pulse therapy produced an immediate but temporary anti-inflammatory effect lasting for a maximum of four to eight weeks. It also caused a lasting depression of serum IgG, but no effect was observed on the proportion of T and B lymphocytes, proliferative responses, or on concanavalin A induced suppressor cell activity, and there was no effect on the amount of circulating immune complexes. The bone mineral content decreased similarly in the two groups, and methylprednisolone pulses had no effect on the progression of erosions on x rays during an observation period of eight months. A single pulse of methylprednisolone can give a short lasting anti-inflammatory effect but is of little or no value in the long term treatment of rheumatoid arthritis.</description><subject>Adult</subject><subject>Aged</subject><subject>Arthritis, Rheumatoid - blood</subject><subject>Arthritis, Rheumatoid - drug therapy</subject><subject>Arthritis, Rheumatoid - pathology</subject><subject>Azathioprine - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Bones, joints and connective tissue. Antiinflammatory agents</subject><subject>Clinical Trials as Topic</subject><subject>Double-Blind Method</subject><subject>Drug Therapy, Combination</subject><subject>Female</subject><subject>Gold - therapeutic use</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Methylprednisolone - administration &amp; dosage</subject><subject>Middle Aged</subject><subject>Penicillamine - therapeutic use</subject><subject>Pharmacology. 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Methylprednisolone pulse therapy produced an immediate but temporary anti-inflammatory effect lasting for a maximum of four to eight weeks. It also caused a lasting depression of serum IgG, but no effect was observed on the proportion of T and B lymphocytes, proliferative responses, or on concanavalin A induced suppressor cell activity, and there was no effect on the amount of circulating immune complexes. The bone mineral content decreased similarly in the two groups, and methylprednisolone pulses had no effect on the progression of erosions on x rays during an observation period of eight months. A single pulse of methylprednisolone can give a short lasting anti-inflammatory effect but is of little or no value in the long term treatment of rheumatoid arthritis.</abstract><cop>London</cop><pub>BMJ Publishing Group Ltd and European League Against Rheumatism</pub><pmid>3296967</pmid><doi>10.1136/ard.46.4.290</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record>
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subjects Adult
Aged
Arthritis, Rheumatoid - blood
Arthritis, Rheumatoid - drug therapy
Arthritis, Rheumatoid - pathology
Azathioprine - therapeutic use
Biological and medical sciences
Bones, joints and connective tissue. Antiinflammatory agents
Clinical Trials as Topic
Double-Blind Method
Drug Therapy, Combination
Female
Gold - therapeutic use
Humans
Male
Medical sciences
Methylprednisolone - administration & dosage
Middle Aged
Penicillamine - therapeutic use
Pharmacology. Drug treatments
title Combination of methylprednisolone pulse therapy and remission inducing drugs in rheumatoid arthritis
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