Real-Time Pyruvate Chemical Conversion Monitoring Enabled by PHIP

In recent years, parahydrogen-induced polarization side arm hydrogenation (PHIP-SAH) has been applied to hyperpolarize [1-13C]­pyruvate and map its metabolic conversion to [1-13C]­lactate in cancer cells. Developing on our recent MINERVA pulse sequence protocol, in which we have achieved 27% [1-13C]...

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Veröffentlicht in:	Journal of the American Chemical Society 2023-03, Vol.145 (10), p.5864-5871
Hauptverfasser:	Stevanato, Gabriele, Ding, Yonghong, Mamone, Salvatore, Jagtap, Anil P., Korchak, Sergey, Glöggler, Stefan
Format:	Artikel
Sprache:	eng
Schlagworte:	HeLa Cells Humans Hydrogen Peroxide Hydrogenation Lactic Acid Pyruvic Acid - metabolism
Online-Zugang:	Volltext
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