Estimation of Calcium Titanate or Erbium Oxide Nanoparticles Induced Cytotoxicity and Genotoxicity in Normal HSF Cells
Extensive uses of calcium titanate nanoparticles (CaTiO 3 -NPs) and erbium oxide nanoparticles (Er 2 O 3 -NPs) increase their release into the environment and human exposure, particularly through skin contact. However, there are almost no studies available on the effect of these nanoparticles on s...
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| Veröffentlicht in: | Biological trace element research 2023-05, Vol.201 (5), p.2311-2318 |
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| creator | Mohamed, Hanan R. H. Ibrahim, Maria M. H. Soliman, Esraa S. M. Safwat, Gehan Diab, Ayman |
| description |
Extensive uses of calcium titanate nanoparticles (CaTiO
3
-NPs) and erbium oxide nanoparticles (Er
2
O
3
-NPs) increase their release into the environment and human exposure, particularly through skin contact. However, there are almost no studies available on the effect of these nanoparticles on skin integrity. Therefore, this study was undertaken to estimate CaTiO
3
-NP- or Er
2
O
3
-NP-induced cytotoxicity and genotoxicity in normal human skin fibroblast (HSF) cells. Cell viability was measured using sulforhodamine B (SRB) assay, while the level of DNA damage was detected using the alkaline comet assay. The intracellular levels of reactive oxygen species (ROS) as well as the expression level of p53, Bax, and Bcl2 genes were detected. Although the viability of HSF cells was non-markedly changed after 24 h, prolonged treatment with CaTiO3-NPs or Er2O3-NPs for 72 h induced concentration-dependent death of HSF cells. Treatment of normal HSF cells with IC50/72 h of CaTiO3-NPs or Er2O3-NPs did not cause marked changes in the intracellular level of ROS, DNA damage parameters, and expression levels of apoptosis genes compared to their values in the untreated HSF cells. We thus concluded that CaTiO3-NPs or Er2O3-NPs cause time- and concentration-dependent cytotoxicity toward normal HSF cells. However, safe and non-genotoxic effects were demonstrated by the apparent non-significant changes in intracellular ROS level, DNA integrity, and apoptotic genes’ expression after exposure of normal HSF cells to nanoparticles. Thus, it is recommended that further studies be conducted to further understand the toxic and biological effects of CaTiO
3
-NPs and Er2O3-NPs. |
| doi_str_mv | 10.1007/s12011-022-03354-9 |
| format | Article |
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Extensive uses of calcium titanate nanoparticles (CaTiO
3
-NPs) and erbium oxide nanoparticles (Er
2
O
3
-NPs) increase their release into the environment and human exposure, particularly through skin contact. However, there are almost no studies available on the effect of these nanoparticles on skin integrity. Therefore, this study was undertaken to estimate CaTiO
3
-NP- or Er
2
O
3
-NP-induced cytotoxicity and genotoxicity in normal human skin fibroblast (HSF) cells. Cell viability was measured using sulforhodamine B (SRB) assay, while the level of DNA damage was detected using the alkaline comet assay. The intracellular levels of reactive oxygen species (ROS) as well as the expression level of p53, Bax, and Bcl2 genes were detected. Although the viability of HSF cells was non-markedly changed after 24 h, prolonged treatment with CaTiO3-NPs or Er2O3-NPs for 72 h induced concentration-dependent death of HSF cells. Treatment of normal HSF cells with IC50/72 h of CaTiO3-NPs or Er2O3-NPs did not cause marked changes in the intracellular level of ROS, DNA damage parameters, and expression levels of apoptosis genes compared to their values in the untreated HSF cells. We thus concluded that CaTiO3-NPs or Er2O3-NPs cause time- and concentration-dependent cytotoxicity toward normal HSF cells. However, safe and non-genotoxic effects were demonstrated by the apparent non-significant changes in intracellular ROS level, DNA integrity, and apoptotic genes’ expression after exposure of normal HSF cells to nanoparticles. Thus, it is recommended that further studies be conducted to further understand the toxic and biological effects of CaTiO
3
-NPs and Er2O3-NPs.</description><identifier>ISSN: 0163-4984</identifier><identifier>EISSN: 1559-0720</identifier><identifier>DOI: 10.1007/s12011-022-03354-9</identifier><identifier>PMID: 35907160</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Apoptosis ; Bioassays ; Biochemistry ; Biological effects ; Biomedical and Life Sciences ; Biotechnology ; Calcium ; Calcium oxide ; Calcium titanate ; Cell death ; Cell Survival ; Cell viability ; Cells ; Comet assay ; Cytotoxicity ; Damage detection ; Deoxyribonucleic acid ; DNA ; DNA Damage ; Erbium ; Erbium oxide ; Fibroblasts ; Gene expression ; Genes ; Genotoxicity ; Humans ; Integrity ; Intracellular ; Intracellular levels ; Life Sciences ; Metal Nanoparticles - toxicity ; Nanoparticles ; Nanoparticles - toxicity ; Nutrition ; Oncology ; Oxidative Stress ; p53 Protein ; Reactive oxygen species ; Reactive Oxygen Species - metabolism ; Skin ; Sulforhodamine ; Toxicity ; Toxicity tests</subject><ispartof>Biological trace element research, 2023-05, Vol.201 (5), p.2311-2318</ispartof><rights>The Author(s) 2022</rights><rights>2022. The Author(s).</rights><rights>The Author(s) 2022. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c475t-dee011c064812903078fcac5d127ec3334de6edca4446851d3bafe6df9f25d413</citedby><cites>FETCH-LOGICAL-c475t-dee011c064812903078fcac5d127ec3334de6edca4446851d3bafe6df9f25d413</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12011-022-03354-9$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12011-022-03354-9$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35907160$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mohamed, Hanan R. H.</creatorcontrib><creatorcontrib>Ibrahim, Maria M. H.</creatorcontrib><creatorcontrib>Soliman, Esraa S. M.</creatorcontrib><creatorcontrib>Safwat, Gehan</creatorcontrib><creatorcontrib>Diab, Ayman</creatorcontrib><title>Estimation of Calcium Titanate or Erbium Oxide Nanoparticles Induced Cytotoxicity and Genotoxicity in Normal HSF Cells</title><title>Biological trace element research</title><addtitle>Biol Trace Elem Res</addtitle><addtitle>Biol Trace Elem Res</addtitle><description>
Extensive uses of calcium titanate nanoparticles (CaTiO
3
-NPs) and erbium oxide nanoparticles (Er
2
O
3
-NPs) increase their release into the environment and human exposure, particularly through skin contact. However, there are almost no studies available on the effect of these nanoparticles on skin integrity. Therefore, this study was undertaken to estimate CaTiO
3
-NP- or Er
2
O
3
-NP-induced cytotoxicity and genotoxicity in normal human skin fibroblast (HSF) cells. Cell viability was measured using sulforhodamine B (SRB) assay, while the level of DNA damage was detected using the alkaline comet assay. The intracellular levels of reactive oxygen species (ROS) as well as the expression level of p53, Bax, and Bcl2 genes were detected. Although the viability of HSF cells was non-markedly changed after 24 h, prolonged treatment with CaTiO3-NPs or Er2O3-NPs for 72 h induced concentration-dependent death of HSF cells. Treatment of normal HSF cells with IC50/72 h of CaTiO3-NPs or Er2O3-NPs did not cause marked changes in the intracellular level of ROS, DNA damage parameters, and expression levels of apoptosis genes compared to their values in the untreated HSF cells. We thus concluded that CaTiO3-NPs or Er2O3-NPs cause time- and concentration-dependent cytotoxicity toward normal HSF cells. However, safe and non-genotoxic effects were demonstrated by the apparent non-significant changes in intracellular ROS level, DNA integrity, and apoptotic genes’ expression after exposure of normal HSF cells to nanoparticles. Thus, it is recommended that further studies be conducted to further understand the toxic and biological effects of CaTiO
3
-NPs and Er2O3-NPs.</description><subject>Apoptosis</subject><subject>Bioassays</subject><subject>Biochemistry</subject><subject>Biological effects</subject><subject>Biomedical and Life Sciences</subject><subject>Biotechnology</subject><subject>Calcium</subject><subject>Calcium oxide</subject><subject>Calcium titanate</subject><subject>Cell death</subject><subject>Cell Survival</subject><subject>Cell viability</subject><subject>Cells</subject><subject>Comet assay</subject><subject>Cytotoxicity</subject><subject>Damage detection</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>DNA Damage</subject><subject>Erbium</subject><subject>Erbium oxide</subject><subject>Fibroblasts</subject><subject>Gene expression</subject><subject>Genes</subject><subject>Genotoxicity</subject><subject>Humans</subject><subject>Integrity</subject><subject>Intracellular</subject><subject>Intracellular levels</subject><subject>Life Sciences</subject><subject>Metal Nanoparticles - toxicity</subject><subject>Nanoparticles</subject><subject>Nanoparticles - toxicity</subject><subject>Nutrition</subject><subject>Oncology</subject><subject>Oxidative Stress</subject><subject>p53 Protein</subject><subject>Reactive oxygen species</subject><subject>Reactive Oxygen Species - metabolism</subject><subject>Skin</subject><subject>Sulforhodamine</subject><subject>Toxicity</subject><subject>Toxicity tests</subject><issn>0163-4984</issn><issn>1559-0720</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kcluFDEQhi0EIpPAC3BAljg3KW_t7hNCrckiRcmBcLY8tjs46rEH2w2Zt8mz5MlwMlngwqmkqq_-Wn6EPhD4TADkYSYUCGmA0gYYE7zpX6EFEaJvQFJ4jRZAWtbwvuN7aD_nawAiac_eoj0mepCkhQX6vczFr3XxMeA44kFPxs9rfOmLDro4HBNeptV96uLGW4fPdYgbnYo3k8v4NNjZOHt3O2xLLPHGG1-2WAeLj114SfiAz2Na6wmffDvCg5um_A69GfWU3fvHeIC-Hy0vh5Pm7OL4dPh61hguRWmsc_VEAy3vCO2BgexGo42whEpnGGPcutZZoznnbSeIZSs9utaO_UiF5YQdoC873c28WlfQhZL0pDapHp22Kmqv_q0E_0NdxV-qfpgC5aIqfHpUSPHn7HJR13FOoS6tqOwkF63oaKXojjIp5pzc-DyCwL2WVDu3VHVLPbil-tr08e_lnlue7KkA2wG5lsKVSy-z_yP7B5PFowk</recordid><startdate>20230501</startdate><enddate>20230501</enddate><creator>Mohamed, Hanan R. 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H. ; Ibrahim, Maria M. H. ; Soliman, Esraa S. M. ; Safwat, Gehan ; Diab, Ayman</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c475t-dee011c064812903078fcac5d127ec3334de6edca4446851d3bafe6df9f25d413</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Apoptosis</topic><topic>Bioassays</topic><topic>Biochemistry</topic><topic>Biological effects</topic><topic>Biomedical and Life Sciences</topic><topic>Biotechnology</topic><topic>Calcium</topic><topic>Calcium oxide</topic><topic>Calcium titanate</topic><topic>Cell death</topic><topic>Cell Survival</topic><topic>Cell viability</topic><topic>Cells</topic><topic>Comet assay</topic><topic>Cytotoxicity</topic><topic>Damage detection</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>DNA Damage</topic><topic>Erbium</topic><topic>Erbium oxide</topic><topic>Fibroblasts</topic><topic>Gene expression</topic><topic>Genes</topic><topic>Genotoxicity</topic><topic>Humans</topic><topic>Integrity</topic><topic>Intracellular</topic><topic>Intracellular levels</topic><topic>Life Sciences</topic><topic>Metal Nanoparticles - toxicity</topic><topic>Nanoparticles</topic><topic>Nanoparticles - toxicity</topic><topic>Nutrition</topic><topic>Oncology</topic><topic>Oxidative Stress</topic><topic>p53 Protein</topic><topic>Reactive oxygen species</topic><topic>Reactive Oxygen Species - metabolism</topic><topic>Skin</topic><topic>Sulforhodamine</topic><topic>Toxicity</topic><topic>Toxicity tests</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mohamed, Hanan R. H.</creatorcontrib><creatorcontrib>Ibrahim, Maria M. H.</creatorcontrib><creatorcontrib>Soliman, Esraa S. 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H.</au><au>Ibrahim, Maria M. H.</au><au>Soliman, Esraa S. M.</au><au>Safwat, Gehan</au><au>Diab, Ayman</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Estimation of Calcium Titanate or Erbium Oxide Nanoparticles Induced Cytotoxicity and Genotoxicity in Normal HSF Cells</atitle><jtitle>Biological trace element research</jtitle><stitle>Biol Trace Elem Res</stitle><addtitle>Biol Trace Elem Res</addtitle><date>2023-05-01</date><risdate>2023</risdate><volume>201</volume><issue>5</issue><spage>2311</spage><epage>2318</epage><pages>2311-2318</pages><issn>0163-4984</issn><eissn>1559-0720</eissn><abstract>
Extensive uses of calcium titanate nanoparticles (CaTiO
3
-NPs) and erbium oxide nanoparticles (Er
2
O
3
-NPs) increase their release into the environment and human exposure, particularly through skin contact. However, there are almost no studies available on the effect of these nanoparticles on skin integrity. Therefore, this study was undertaken to estimate CaTiO
3
-NP- or Er
2
O
3
-NP-induced cytotoxicity and genotoxicity in normal human skin fibroblast (HSF) cells. Cell viability was measured using sulforhodamine B (SRB) assay, while the level of DNA damage was detected using the alkaline comet assay. The intracellular levels of reactive oxygen species (ROS) as well as the expression level of p53, Bax, and Bcl2 genes were detected. Although the viability of HSF cells was non-markedly changed after 24 h, prolonged treatment with CaTiO3-NPs or Er2O3-NPs for 72 h induced concentration-dependent death of HSF cells. Treatment of normal HSF cells with IC50/72 h of CaTiO3-NPs or Er2O3-NPs did not cause marked changes in the intracellular level of ROS, DNA damage parameters, and expression levels of apoptosis genes compared to their values in the untreated HSF cells. We thus concluded that CaTiO3-NPs or Er2O3-NPs cause time- and concentration-dependent cytotoxicity toward normal HSF cells. However, safe and non-genotoxic effects were demonstrated by the apparent non-significant changes in intracellular ROS level, DNA integrity, and apoptotic genes’ expression after exposure of normal HSF cells to nanoparticles. Thus, it is recommended that further studies be conducted to further understand the toxic and biological effects of CaTiO
3
-NPs and Er2O3-NPs.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>35907160</pmid><doi>10.1007/s12011-022-03354-9</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Apoptosis Bioassays Biochemistry Biological effects Biomedical and Life Sciences Biotechnology Calcium Calcium oxide Calcium titanate Cell death Cell Survival Cell viability Cells Comet assay Cytotoxicity Damage detection Deoxyribonucleic acid DNA DNA Damage Erbium Erbium oxide Fibroblasts Gene expression Genes Genotoxicity Humans Integrity Intracellular Intracellular levels Life Sciences Metal Nanoparticles - toxicity Nanoparticles Nanoparticles - toxicity Nutrition Oncology Oxidative Stress p53 Protein Reactive oxygen species Reactive Oxygen Species - metabolism Skin Sulforhodamine Toxicity Toxicity tests |
| title | Estimation of Calcium Titanate or Erbium Oxide Nanoparticles Induced Cytotoxicity and Genotoxicity in Normal HSF Cells |
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